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Biomedicines
Special Issues
Molecular Research of Neurological and Psychiatric Disorders
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Molecular Research of Neurological and Psychiatric Disorders

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 976

Special Issue Editor

Dr. Yuen Gao

E-Mail Website
Guest Editor
Department of Physiology, College of Nature Sciences, Michigan State University, East Lansing, MI 48824, USA
Interests: epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurological and psychiatric disorders affect millions globally, impacting the quality of life and productivity, and imposing significant burdens on healthcare systems. The etiology of neurological and psychiatric disorders is notoriously complex, involving intricate interplays of genetic, environmental and neurobiological factors. Molecular research holds the key to decoding these interactions, identifying disease mechanisms and uncovering potential points of intervention.

The Special Issue aims to explore the intricate molecular mechanisms underlying neurological and psychiatric conditions, fostering a deeper understanding of their etiology, progression and potential therapeutic targets. This issue will focus on the latest molecular biology techniques, genetic findings and biochemical pathways involved in disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, schizophrenia, depression, and bipolar disorder and autism spectrum disorders. An emphasis will be placed on cutting-edge research that unveils the role of genetic variations, epigenetic modifications, neurotransmitter dysregulation and protein misfolding in the pathogenesis of these complex diseases. By highlighting innovative studies on molecular diagnostics, biomarker discovery and the development of novel therapeutic strategies, this Special Issue seeks to bridge the gap between molecular insights and clinical applications, offering hope for patients and advancements in personalized medicine. Through interdisciplinary research and collaboration, it aims to contribute significantly to the understanding of the molecular basis of neurological and psychiatric disorders, paving the way for more effective treatments and interventions.

Dr. Yuen Gao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular biology
  • neurodegenerative disorders
  • psychiatry
  • biomarkers
  • therapeutic targets

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Published Papers (1 paper)

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Research

12 pages, 561 KiB  
Article
Association of Monoamine Oxidase A Gene Promoter Region (30 bp μVNTR) Polymorphism with Serum Levels in Multiple Psychiatric Disorders
by Aisha Nasir Hashmi, Rizwan Taj, Zehra Agha, Raheel Qamar, Jamal B. Williams and Maleeha Azam
Biomedicines 2025, 13(3), 698; https://doi.org/10.3390/biomedicines13030698 - 12 Mar 2025
Viewed by 495
Abstract
Background: Monoamine oxidase A (MAOA) has a role in metabolising different biogenic amines, including dopamine. Functional studies have revealed the effect of promoter region variants on the transcriptional activity of the MAOA that consequently affects the homeostasis of the biogenic amines which might [...] Read more.
Background: Monoamine oxidase A (MAOA) has a role in metabolising different biogenic amines, including dopamine. Functional studies have revealed the effect of promoter region variants on the transcriptional activity of the MAOA that consequently affects the homeostasis of the biogenic amines which might implicate in the aetiology of multiple psychiatric conditions. Objectives: The current study aimed to determine the influence of the promoter region 30 base pair (bp), a variable number of tandem repeats (VNTR) of the MAOA, on its serum levels and association with schizophrenia (SHZ), bipolar disorder (BD), and major depressive disorder (MDD) in the Pakistani population. Methods: A total of 1062 subjects [MDD n = 416, BD n = 200, SHZ n = 97 and controls n = 349], were genotyped for MAOA-30bp µVNTR through standard polymerase chain reaction technique and logistic regression was applied to determine the genetic association. Serum MAOA levels were determined through enzyme-linked immunosorbent assay (ELISA) and the Mann-Whitney U test was applied. Results: In genotype analysis, eight different repeat (R) alleles of MAOA-30 bp µVNTR were observed, where 4.5R, 5.5R, and 6R were the rare repeats found in the current Pakistani cohort. In serum-based analysis the total MAOA serum levels were found to be significantly elevated in SHZ; however, in sub-group analysis, significantly higher serum levels of MAOA were observed only in the rare allele groups of MDD, BD, and SHZ. Conclusions: The current study gives us further insights into the complex nature of MAOA regulation and its genetic and serum-levels association with different psychiatric conditions. Full article
(This article belongs to the Special Issue Molecular Research of Neurological and Psychiatric Disorders)
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