Genetic and Epigenetics of Kidney Development: Pathologies of Renal Anomalies and Kidney Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 840

Special Issue Editor


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Guest Editor
Department of Pediatric Nephrology, Tulane University School of Medicine, New Orleans, LA, 70112, USA
Interests: epigenetic regulation of kidney development and diseases

Special Issue Information

Dear Colleagues,

Congenital anomalies of the kidney and urinary tract (CAKUT) contribute significantly to renal failure and predispose to the development of kidney disease. Genetic and epigenetic regulations are very important for kidney formation and the development of kidney disease. Thus, there is a critical need to fully understand the molecular mechanisms underlying kidney development and diseases to provide a strong conceptual framework for the development of therapeutic interventions to prevent and treat CAJUT and progressive kidney disease.

Dr. Hongbing Liu
Guest Editor

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Keywords

  • genetics
  • epigenetics
  • CAKUT
  • kidney development
  • kidney diseases

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Published Papers (1 paper)

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Review

17 pages, 514 KiB  
Review
The Impact of Autosomal Dominant Polycystic Kidney Disease in Children: A Nephrological, Nutritional, and Psychological Point of View
by Matteo Guarnaroli, Flavia Padoan, Cristiano Fava, Maria Giulia Benetti, Milena Brugnara, Angelo Pietrobelli, Giorgio Piacentini and Luca Pecoraro
Biomedicines 2024, 12(8), 1823; https://doi.org/10.3390/biomedicines12081823 - 12 Aug 2024
Viewed by 526
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by the formation of numerous fluid-filled cysts in the kidneys, leading to progressive renal failure and various extrarenal complications, including hypertension. This review explores the genetic basis of ADPKD, including emerging evidence [...] Read more.
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by the formation of numerous fluid-filled cysts in the kidneys, leading to progressive renal failure and various extrarenal complications, including hypertension. This review explores the genetic basis of ADPKD, including emerging evidence of epigenetic mechanisms in modulating gene expression and disease progression in ADPKD. Furthermore, it proposes to examine the pathological characteristics of this condition at the nephrological, cardiovascular, nutritional, and psychological levels, emphasizing that the follow-up of patients with ADPKD should be multidisciplinary from a young pediatric age. Full article
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