The Herpesvirus–Host Interactions

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2353

Special Issue Editor


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Guest Editor
Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, USA
Interests: herpesvirus; virus infection; immune evasion; vaccine

Special Issue Information

Dear Colleagues,

This Special Issue focuses on recent advances in the field of herpesvirus–host interactions to address unresolved issues, provide new insights, and attract a wide range of readers.

Nine human herpesviruses from the alpha, beta, and gammaherpesviruses groups can cause a range of diseases during the primary virus infection and reactivation stages. Herpesviruses establish a latent phase of infection that persists throughout the life of the host. During the herpesvirus life cycle, both virus and host respond to each other through various complex processes, and these new studies can provide crucial insights into the mechanism that virus use to manipulate their host and cause disease. Herpesvirus infections are ubiquitous and present a global health challenge. Understanding the interplay of viral and host cell factors at each stage of the viral life cycle may provide a basis for the design of antiviral agents and vaccines.

This Special Issue includes a cohesive collection of research papers, short communications, and review articles contributed by experts on herpesviruses.

Dr. Murali Muniraju
Guest Editor

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Keywords

herpes simplex virus; varicella zoster virus; human cytomegalovirus; human herpesvirus 6; Epstein Barr virus; Kaposi sarcoma associated herpesvirus; virus infection; immune system; pathogenesis; interventions

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Published Papers (1 paper)

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Research

14 pages, 1644 KiB  
Article
DNA Damage Response Differentially Affects BoHV-1 Gene Transcription in Cell Type-Dependent Manners
by Linke Tang, Weifeng Yuan, Shitao Li, Xiuyan Ding and Liqian Zhu
Biomedicines 2022, 10(9), 2282; https://doi.org/10.3390/biomedicines10092282 - 14 Sep 2022
Cited by 2 | Viewed by 1590
Abstract
Bovine herpesvirus 1 (BoHV-1), an important pathogen of cattle, is also a promising oncolytic virus. Recent studies have demonstrated that the virus infection induces DNA damage and DNA damage response (DDR), potentially accounting for virus infection-induced cell death and oncolytic effects. However, whether [...] Read more.
Bovine herpesvirus 1 (BoHV-1), an important pathogen of cattle, is also a promising oncolytic virus. Recent studies have demonstrated that the virus infection induces DNA damage and DNA damage response (DDR), potentially accounting for virus infection-induced cell death and oncolytic effects. However, whether the global DDR network affects BoHV-1 productive infection remains to be elucidated. In this study, we show that global DDR induced by ultraviolet (UV) irradiation prior to BoHV-1 infection differentially affected transcription of immediate early (IE) genes, such as infected cell protein 0 (bICP0) and bICP22, in a cell-type-dependent manner. In addition, UV-induced DDR may affect the stabilization of viral protein levels, such as glycoprotein C (gC) and gD, because the variation in mRNA levels of gC and gD as a consequence of UV treatment were not in line with the variation in individual protein levels. The virus productive infection also affects UV-primed DDR signaling, as demonstrated by the alteration of phosphorylated histone H2AX (γH2AX) protein levels and γH2AX formation following virus infection. Taken together, for the first time, we evidenced the interplay between UV-primed global DDR and BoHV-1 productive infection. UV-primed global DDR differentially modulates the transcription of virus genes and stabilization of virus protein. Vice versa, the virus infection may affect UV-primed DDR signaling. Full article
(This article belongs to the Special Issue The Herpesvirus–Host Interactions)
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