The Role of Adenosine A(2A) Receptor Antagonists in Neurology and Psychiatric Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2189
Special Issue Editors
Interests: neurodegenerative disease; Parkinson's disease (PD)
Special Issue Information
Dear Colleagues,
The identification and cloning of the adenosine A2A receptor and the finding of its selective localisation to the brain—most notably to neurones in the basal ganglia and in limbic brain regions—and to glial cells, opened a new vista on approaches to the treatment of both neurological and psychiatric illnesses and to the potential for achieving neuroprotection and/or disease modification. In this supplement, we explore the molecular biology, biochemistry and functional roles of the adenosine A2A receptor. These are put into the context of the use of adenosine A2A receptor antagonists in the symptomatic treatment of Parkinson’s disease and the acceptable safety profile in combination with current dopaminergic therapies. In addition, we look at the functional significance of the adenosine A2A receptor in a range of other neurodegenerative diseases, including motor neurone disease, Huntington’s chorea and multiple sclerosis. We also explore the potential of adenosine A2A receptors and A2A receptor antagonists as a novel approach for the treatment of anxiety, depression, cognition and sleep disturbance. Finally, the key localisation of A2A receptors on glutamatergic neurones and their role in the control of excitotoxic mechanisms together with their involvement in the regulation of glial cell activity are used to illustrate how adenosine A2A receptor antagonists may have a future role in modifying the progression of degenerative illnesses of the central nervous system.
Dr. Peter Jenner
Dr. Akihisa Mori
Guest Editors
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Keywords
- adenosine
- adenosine A2A receptor
- adenosine A2A receptor antagonist
- basal ganglia
- limbic system Parkinson’s disease
- neurodegeneration
- motor neuron disease
- Huntington's disease
- anxiety
- depression
- cognition
- sleep disturbance. glutamatergic neurons
- glial cells
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