Anti-Angiogenesis Therapeutics in Cancer

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (30 March 2017) | Viewed by 37290

Special Issue Editor


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Guest Editor
1. Retired, The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, 1 Discovery Drive (Room 238), Rensselaer, NY 12144, USA
2. Vascular Vision Pharmaceuticals Co., Rensselaer Polytechnic Park, Troy, NY 12180, USA
Interests: pharmaceuticals; biopharmaceuticals and diagnostics; nanomedicine; cardiovascular diseases; neurological disorders; hematology and oncology; biosimilar and nanosimilar; angiogenesis; inflammation; thrombosis; integrin and cell adhesion molecules; target identification; molecular mechanisms and signaling pathways; preclinical; clinical; marketing and post marketing studies; regulatory and ethical issues
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Special Issue Information

Dear Colleague,

The aim of this Special Issue is to cover the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in Oncology. The Special Issue is aimed to cover preclinical and clinical steps involved in the discovery and development of anti-angiogenesis targets in cancer and to discuss mechanisms involved in the modulation of angiogenesis in relation to cancer therapy. FDA approved anti-angiogenesis agents in cancer therapeutics and limitations will be reviewed. Furthermore, the implications of Nanotechnology in expanding the utility of existing and new novel anti-angiogenesis strategies in cancer will also be reviewed.

Prof. Dr. Shaker A. Mousa
Guest Editor

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Keywords

  • Angiogenesis and anti-angiogenesis in hematological malignancies
  • Angiogenesis and lymphogenesis in cancer (tumor growth, invasion, and metastasis)
  • Survey of different anti-angiogenesis strategies
  • Integrin in angiogenesis and lymphogenesis
  • Anti-VEGF (vascular endothelial growth factor) in angiogenesis modulation and cancer therapy
  • Tyrosine kinase inhibitors (TKI) in angiogenesis modulation and cancer therapy
  • Multi-targeted anti-angiogenesis therapy in cancer therapy
  • Micro RNA and angiogenesis modulation
  • Naturally occurring anti-angiogenesis agents
  • Angiogenesis biomarkers and impact on personalized management
  • Combination of anti-angiogenesis and chemotherapeutics
  • Nanotechnology in enhancing the utility of anti-angiogenesis agents—combinations with standard anti-cancer
  • Nano-targeted anti-angiogenesis agents in cancer detection

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Published Papers (1 paper)

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Review
The Role of Angiogenesis in Cancer Treatment
by Mehdi Rajabi and Shaker A. Mousa
Biomedicines 2017, 5(2), 34; https://doi.org/10.3390/biomedicines5020034 - 21 Jun 2017
Cited by 490 | Viewed by 36204
Abstract
A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be [...] Read more.
A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be enough to eradicate tumors. Decreased anti-angiogenesis activity in single mechanism-based anti-angiogenic strategies is due to the redundancy, multiplicity, and development of compensatory mechanism by which blood vessels are remodeled. Improving anti-angiogenesis drug efficacy will require identification of broad-spectrum anti-angiogenesis targets. These strategies may have novel features, such as increased porosity, and are the result of complex interactions among endothelial cells, extracellular matrix proteins, growth factors, pericyte, and smooth muscle cells. Thus, combinations of anti-angiogenic drugs and other anticancer strategies such as chemotherapy appear essential for optimal outcome in cancer patients. This review will focus on the role of anti-angiogenesis strategies in cancer treatment. Full article
(This article belongs to the Special Issue Anti-Angiogenesis Therapeutics in Cancer)
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