Dendritic Cells and Cancer Immunotherapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (31 May 2016) | Viewed by 38185
Special Issue Editors
Interests: cancer immunotherapy; suppressive tumor microenvironment; signaling networks; immunogenic cell death
Interests: dendritic cells, immunotherapy, tumor microenvironment, T cell polarization, immune tolerance
Special Issue Information
Dear Colleagues,
Dendritic cells (DCs) are a specialized population of professional antigen-presenting cells that play a crucial role in the induction of adaptive immune responses and in the maintenance of peripheral tolerance. As initiators of antigen-specific immune responses, DCs are imperative in establishing anti-tumor adaptive immune responses. This role has been exploited for therapeutic purposes in various anti-tumor vaccination strategies. Over the years, many insights into the qualities and functions of DCs have been gained. This acquired knowledge has been translated into improved DC-based vaccines through the better selection of DC subtypes for vaccine preparation and the optimization of peptide selection, loading strategies, and routes of administration. Until now, anti-tumor DC vaccines have only proven efficacious in a small population of cancer patients.
Therefore, this Special Issue on dendritic cell vaccines will focus on strategies for improving DC vaccination in combination with other therapies, such as checkpoint inhibitors, chemotherapy, or radiation therapy, that alter the tumor microenvironment. Of particular interest will be manuscripts discussing the use of DC vaccines in prophylactic or adjuvant settings through the targeting of cancer stem cells or dormant tumor cells. Manuscripts describing the accumulation DC subtypes in the tumor environment and how they might be targeted for therapeutic benefit are also welcome. This Special Issue will include original research, review articles, commentaries, and editorials discussing the use of DC vaccines in cancer immunotherapy. Topics of interest for this Special Issue include, but are not limited to, the key words listed below.
Dr. Stanleyson Hato
Dr. Ghaith Bakdash
Guest Editors
Manuscript Submission Information
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Keywords
- DC-based anti-cancer vaccines
- DC vaccines combinded with checkpoint inhibitors
- DC vaccines combinded with chemotherapy or small molecule inhibitors
- DC maturation/activation and tumor-associated “danger” signals
- Cross-presentation of tumor antigens
- The role of DC in the induction of tumor-specific T cell responses
- The influence of tumor-derived factors on DC differentiation, maturation, activation, and function
- Immunosuppression by immature myeloid cells such as myeloid-derived suppressor cells
- Regulatory DCs and cancer
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