Gene Therapy Coming of Age
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 69761
Special Issue Editor
Interests: viral gene therapy; viral vaccines; gene expression using viral vectors; structural biology; epigenetics; nutrigenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gene therapy was once considered as the medicine of the future, back in the late 1990s, but it then suffered some unexpected setbacks in terms of virus-based delivery approaches. Nevertheless, gene therapy is now experiencing a second coming due to its improved efficacy and safety of vector delivery. This has led to the initiation of a large number of clinical trials and even approval of the first gene therapy drugs. Furthermore, recent progress in RNA interference, RNA delivery, and gene-editing technologies has broadened the application range of gene therapy. Today, both viral and nonviral vectors have found various applications for treatment of several diseases, such as cancer, metabolic, neurodegenerative, cardiovascular, and muscular diseases. The Special Issue on Gene Therapy in Biomedicines is therefore a particularly topical addition to the field, providing up-to-date insight into delivery vector types, safety-related issues, proof-of-principle in preclinical disease models, clinical trials in healthy volunteers and patients, and approval of gene therapy-based drugs.
Dr. Kenneth Lundstrom
Guest Editor
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Keywords
- viral vectors
- nonviral vectors
- RNA interference
- gene editing
- therapy
- prevention
- clinical trials