The Genetic Basis and Molecular Mechanisms of Neurodegeneration
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 547
Special Issue Editor
Interests: genetic basis and molecular mechanisms of neurodegeneration; Alzheimer’s disease; rare neurogenetic disorders; whole-exome sequencing analyses; neurogenetics; hereditary polyneuropathy; hereditary myopathy; hereditary dementia; tardbp; frontotemporal dementia; C9orf72; amyotrophic lateral sclerosis; MAPT; glutamate metabolism
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Special Issue Information
Dear Colleagues,
Neurodegenerative disorders include heterogeneous conditions such as Alzheimer’s disease; frontotemporal, Lewy body, and other dementias; Parkinson’s disease; amyotrophic lateral sclerosis; Huntington’s disease; and prion disorders. These disorders pose an important public health threat given their increasing prevalence due to population aging worldwide. This awareness has encouraged efforts to decipher the genetic and molecular mechanisms underlying these disorders with the aim of developing rational therapeutic approaches.
Despite their phenotypic diversity, neurodegenerative disorders frequently overlap on clinical grounds and share common pathophysiological mechanisms, such as protein misfolding, defective protein degradation, mitochondrial dysfunction, impaired axonal transport, DNA repeat expansions, DNA damage, excitotoxicity, oxidative stress, and aberrant programmed cell death. Accordingly, pathological studies have shown both distinct and common histological features in the brains of patients with neurodegenerative disorders. Concerning the genetic basis of these disorders, they are characterized by phenotypic and genotypic heterogeneity, with pathogenic or predisposing variants in a single gene associated with various phenotypes, and, on the other hand, a single phenotype caused by variants in different genes.
The aim of this Special Issue is to include studies that showcase both common and divergent aspects of neurodegenerative disorders, including their genetic and molecular basis, thus advancing knowledge in the field.
Dr. Ioannis V. Zaganas
Guest Editor
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Keywords
- Alzheimer’s disease
- amyotrophic lateral sclerosis
- Huntington’s disease
- prion disorders
- protein misfolding
- mitochondrial dysfunction
- DNA damage
- oxidative stress
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