Monitoring Anticoagulant
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 41679
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue, “Monitoring Anticoagulants”, aims to update laboratory monitoring practice for current anticoagulants and those more recently introduced, and which require a much lighter survey, except for some well-defined cases at risk of bleeding or thrombosis recurrence. Since the introduction of the first anticoagulant treatments, Vitamin K antagonists and Heparins, the prognosis of thrombotic diseases has been revolutionized. A wide variety of anticoagulants or antithrombotics have been introduced these past years, and requirements for therapy monitoring are highly dependent on the drug. The major associated clinical risks concern occurrence of hemorrhages, whose incidence depends on the patient’s clinical state and drug dosage adjustment. As major bleedings are life-threatening, when present, anticoagulation needs to be reversed without delay. Monitoring efficacy of this reversal is part of the follow-up of anticoagulant therapy.
This issue plans to cover the monitoring of the various groups of anticoagulants available today, from conventional Vitamin K Antagonists or heparins to antiaggregant or fibrinolytic therapies. The more selective and sophisticated approaches required by the newly introduced direct oral anticoagulants, targeted at thrombin or factor Xa, will be addressed. The various laboratory methods available are presented. An appropriate and accurate therapy monitoring ensures the expected safety and efficacy.
Dr. Jean Amiral
Guest Editor
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Keywords
- anticoagulant
- antiaggregant
- antithrombotic
- laboratory monitoring
- bleeding
- hemorrhage reversal
- surgery
- hemostasis testing
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