Neurotoxicity: Mechanisms and Potential Therapeutic Strategies (Closed)
A topical collection in Biomedicines (ISSN 2227-9059). This collection belongs to the section "Neurobiology and Clinical Neuroscience".
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Interests: pancreatic cancer; environmental toxicants; mitochondrial toxicity; apoptosis; cellular regulation; tryptophan-kynurenine pathway; indoleamine 2,3-dioxygenase
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Topical Collection Information
Dear Colleagues,
We are constantly subjected to toxic insults, most of these insults going unnoticed. Whether it is the environment, occupational or intentional exposure, toxicants are a part of our daily lives. As we go through the day, exposure to toxic metals, chemical by-products, particulate matter, volatile gases, pesticides, etc., occurs constantly. In most instances, this exposure is at a very low level, but continues for an extended time. With chronic exposure, we slowly build deficits, such as a loss of free radical scavenging enzymes, altered protein production and epigenetic changes. Collectively leading to signs and symptoms of neurotoxicity. The intent of this Topical Collection is the discuss mechanisms leading to neurotoxicity, and from these mechanisms, what potential therapeutic strategies are being developed. We would like to bring together a diverse group who are examining many different perspectives of neurotoxicity along with groups developing therapeutics to alleviate or prevent these toxic insults.
Prof. David R Wallace
Collection Editor
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Keywords
- Astrocytes
- Microglia
- Neuroinflammation
- Neurodegeneration
- Oxidative Stress
- protein degeneration
- heavy metals
- pesticides