Signal Transduction in Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 6819
Special Issue Editor
Special Issue Information
Dear Colleague,
Signal transduction pathways play important roles in the initiation, progression and metastasis of cancer. Many famous key signaling pathways are closely involved in cancer, such as RAS-related signaling, WNT pathway signaling, Notch and Hedgehog signaling, etc. RAS GTPases are molecular switches that play a critical role in many cancers. WNT signaling has been of considerable interest in both stem cell and cancer research, both in homeostatic maintenance of tissues and organs through their respective somatic stem cells (SSCs) and in cancer stem cells (CSCs). Aberrant activation of the Hedgehog pathway is implicated in the development of a variety of tumors. Thus, the Hedgehog pathway represents an attractive therapeutic target for cancer treatment.
The precise understanding of the regulation of involved signaling, the crosstalk of different signaling pathways, and downstream targets are the focus of this Special Issue. Original research papers as well as concise review manuscripts from experts in the relevant research fields will be considered for publication.
Prof. Dr. Ho Lin
Guest Editor
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