Biomimetic Materials for Anisotropic Tissue Regeneration

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 3138

Special Issue Editor


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Guest Editor
School of Life Sciences, Nantong University, Nantong, China
Interests: biomaterials; composites; stem cell; tissue engineering and regenerative medicine

Special Issue Information

Dear Colleagues,

Anisotropic tissue engineering (e.g., tendon/ligament, nerve) offers a promising strategy to promote functional tissue recovery and then guide tissue repair and regeneration. Recently, biomaterials play an increasingly critical role in the success of tissue-engineering scaffolds. Particularly, numerous research groups have been trying to design and develop biomimetic biomaterials and advanced techniques based on recent momentous discoveries centered around the microenvironment of the extracellular matrix (ECM) and their interplay with cells in order to construct artificial organs and functional tissues for basic biological studies and clinical applications. Biomimetic ECM scaffolds with unique (bio) physicochemical cues, such as 2D topography/3D geometry, viscoelasticity, stiffness, wettability, material component and ECM proteins, etc., can significantly affect cell survival and mediate cell attachment, recruitment, viability, and the self-maintenance or differentiation of stem cells and anisotropic tissue/organ functions. This Special Issue aims to focus on the design and preparation of biomimetic ECM scaffolds relevant to anisotropic tissue repair and regeneration.

Dr. Huihua Yuan
Guest Editor

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Keywords

  • design, preparation, and characterization of bioactive biomaterials
  • functional and smart biomaterials for anisotropic tissue engineering
  • cell–biomaterial interaction
  • tissue-inducing biomaterials
  • cells/signaling combining functional biomaterials for guided tissue regeneration
  • implants for the treatment of disease and tissue regeneration

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Published Papers (1 paper)

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Review

19 pages, 2055 KiB  
Review
Evolution of Electrospinning in Liver Tissue Engineering
by Ashwini Vasudevan, Dinesh M. Tripathi, Subramanian Sundarrajan, Jayarama Reddy Venugopal, Seeram Ramakrishna and Savneet Kaur
Biomimetics 2022, 7(4), 149; https://doi.org/10.3390/biomimetics7040149 - 30 Sep 2022
Cited by 11 | Viewed by 2814
Abstract
The major goal of liver tissue engineering is to reproduce the phenotype and functions of liver cells, especially primary hepatocytes ex vivo. Several strategies have been explored in the recent past for culturing the liver cells in the most apt environment using biological [...] Read more.
The major goal of liver tissue engineering is to reproduce the phenotype and functions of liver cells, especially primary hepatocytes ex vivo. Several strategies have been explored in the recent past for culturing the liver cells in the most apt environment using biological scaffolds supporting hepatocyte growth and differentiation. Nanofibrous scaffolds have been widely used in the field of tissue engineering for their increased surface-to-volume ratio and increased porosity, and their close resemblance with the native tissue extracellular matrix (ECM) environment. Electrospinning is one of the most preferred techniques to produce nanofiber scaffolds. In the current review, we have discussed the various technical aspects of electrospinning that have been employed for scaffold development for different types of liver cells. We have highlighted the use of synthetic and natural electrospun polymers along with liver ECM in the fabrication of these scaffolds. We have also described novel strategies that include modifications, such as galactosylation, matrix protein incorporation, etc., in the electrospun scaffolds that have evolved to support the long-term growth and viability of the primary hepatocytes. Full article
(This article belongs to the Special Issue Biomimetic Materials for Anisotropic Tissue Regeneration)
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