Nerve Conduction Inhibition to Alleviate Disease Symptoms: Clinical Drugs and Medicinal Plant Compounds
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 28 February 2025 | Viewed by 25
Special Issue Editor
Interests: nerve conduction; synaptic transmission; synaptic plasticity; pain; neuron; spinal dorsal horn; sciatic nerve; glutamate receptor; GABA receptor; glycine receptor; TRP channel; analgesic; plant-derived compound; electrophysiology; patch-clamp
Special Issue Information
Dear Colleagues,
Neuronal information is transmitted from the periphery to higher centers by action potential (AP) conduction in nerve fibers and chemical transmission at synapses. Although synaptic transmission is modified by drugs that alleviate various disease symptoms, nerve AP conduction is also a target for the drugs. For instance, there are anesthetics, analgesics, antiepileptics, and antidepressants that inhibit nerve conduction. Even NSAIDs inhibit nerve conduction. Likely, drugs used in folk medicine, many of which are derived from plants, also suppress nerve conduction. Nerve conduction inhibitors have the ability to modulate TRP channels that are involved in sensory transmission, cancer progression, and so on. Nerve conduction inhibition is mainly due to a modulation of voltage-gated sodium and potassium channels that are involved in AP production. It is highly likely that the specific structures of a drug capable of inhibiting nerve conduction are involved in a modulation of activation of the channels. Studies to clarify the chemical structures and mechanisms of the modulation involved and to find new clinical and plant-derived compounds for nerve conduction inhibition are necessary to identify therapeutically effective drugs. We invite authors to submit original research manuscripts, reviews, and communications related to any of these aspects.
Dr. Eiichi Kumamoto
Guest Editor
Manuscript Submission Information
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Keywords
- nerve conduction
- action potential
- clinical drug
- medicinal plant compound
- voltage-gated ion channel
