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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches

edited by

Daniele Di Marino

, Cristina Maracci, Alice Romagnoli and

Stefano Motta

submission deadline 30 Jun 2024 | 9 articles | Viewed by 27415 | Submission Open

Keywords: Protein’ s structure and dynamics; Protein-protein interactions; Point mutations; Molecular biology; Molecular modelling; Molecular dynamics; Biochemistry; Bioinformatics; Protein-ligand interaction; Protein-nucleic acids interaction; Protein’ s conformational changes

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease II

edited by

Liang-Jun Yan

submission deadline 30 Jun 2024 | 8 articles | Viewed by 23558 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy; diabetic kidney disease; redox imbalance; reductive stress; reactive oxygen species; oxidative stress; mitochondrial abnormalities; mitochondrial homeostasis; mitophagy; unfolded protein response

(This special issue belongs to the Section Molecular Medicine)

Melatonin in Health and Disease

edited by

Christophe Ribelayga

submission deadline 30 Jun 2024 | 5 articles | Viewed by 23498 | Submission Open

Keywords: melatonin; melatonin receptors; pineal gland; chronobiology

(This special issue belongs to the Section Molecular Medicine)

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment

edited by

David Lominadze

submission deadline 30 Jun 2024 | 9 articles | Viewed by 22775 | Submission Open

Keywords: blood cells; plasma components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Medicine)

Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini

edited by

Marija Meznaric

Daniela Tavian

and

Sara Missaglia

submission deadline 30 Jun 2024 | 7 articles | Viewed by 15836 | Submission Open

Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies

(This special issue belongs to the Section Molecular Biology)

Fibrodysplasia Ossificans Progressiva (FOP): From Molecular Mechanisms to Therapeutic Strategies

edited by

Frederick S. Kaplan

and

Robert J. Pignolo

submission deadline 30 Jun 2024 | 7 articles | Viewed by 12451 | Submission Open

Keywords: fibrodysplasia ossificans progressiva; bone morphogenetic protein (BMP); signaling pathway; ACVR1; fibro/adipogenic progenitor cells (FAPs); heterotopic ossification

(This special issue belongs to the Section Molecular Medicine)

Eosinophils in Allergy and Related Diseases—Selected Papers from “The Workshop on Eosinophils in Allergy and Related Diseases 2022”

edited by

Yoshiyuki Yamada

and

Akira Kanda

submission deadline 30 Jun 2024 | 6 articles | Viewed by 10187 | Submission Open

Keywords: allergic inflammation; asthma; atopic dermatitis; allergic rhinitis; allergic conjunctivitis; chronic rhinosinusitis with nasal polyp (CRSwNP); eosinophils; eosinophilic pneumonia; eosinophilic chronic rhinosinusitis (ECRS); eosinophilic gastrointestinal diseases (EGIDs); hypereosinophilic syndromes (HESs); eosinophilic granulomatosis with polyangiitis (EGPA)

(This special issue belongs to the Section Molecular Medicine)

Histone Modifications in Health and Diseases

edited by

Chunying Li

Zhe Yang

and Yuning Hou

submission deadline 30 Jun 2024 | 4 articles | Viewed by 9195 | Submission Open

Keywords: histone modifications; lysine methylation; lysine acetylation; histone phosphorylation; histone ubiquitylation; histone sumoylation; human diseases

(This special issue belongs to the Section Biomacromolecules: Proteins)

Sowing the Seed to Ensure the Future of Plant Proteomics: Commemorative Issue in Honor of Dr. Dominique Job (1947–2022)

edited by

Delphine Vincent

Mélisande Blein-Nicolas

and

submission deadline 30 Jun 2024 | 6 articles | Viewed by 8607 | Submission Open

Keywords: model and non-model plant species; crops; forestry; horticulture; ecology; flowering; floral induction; biennial bearing; fruit load; seed physiology; seed metabolism; seed germination; seed vigor; seed viability; seed longevity; desiccation tolerance; dormancy; post-genomics and omics; transcriptomics; proteomics; secretomics; systems biology; biotic stress; plant-microbe interactions (bacteria; fungi; viruses); abiotic stress; oxidative stress and reactive oxygen species (ROS); sulfur metabolism (biotin; Cys; Met; S-AdoMet; protein biotinylation); drought tolerance; post-translational modifications (PTMs); protein turnover; big data; data integration; data mining

(This special issue belongs to the Section Molecular Biology)

RNA Therapeutics

edited by

Peter E. Nielsen

submission deadline 30 Jun 2024 | 3 articles | Viewed by 7917 | Submission Open

Keywords: antisense oligonucleotides (ASO); siRNA; mRNA new chemistries; therapeutic targets/indications; cellular delivery/endosomal escape (LNPs/CPPs); in vivo administration/formulation/efficacy; tissue targeting/PK/PD

(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)

Biomarkers for Pancreatitis and Its Complications

edited by

Paulina Dumnicka

and

Beata Kusnierz-Cabala

submission deadline 30 Jun 2024 | 5 articles | Viewed by 7505 | Submission Open

Keywords: acute pancreatitis; recurrent acute pancreatitis; chronic pancreatitis; pancreatic cancer; diagnostic biomarkers; biomarkers of severity; prognostic biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Advances in Protein-Ligand Interactions: From Structure, Function to Applications

edited by

Mateusz Banach

submission deadline 30 Jun 2024 | 4 articles | Viewed by 6071 | Submission Open

Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes

(This special issue belongs to the Section Molecular Structure and Dynamics)

Novel Insights into Cytochrome P450 Enzymes in Drug Metabolism

edited by

Donglu Zhang

and Lionel Cheruzel

submission deadline 30 Jun 2024 | 3 articles | Viewed by 5216 | Submission Open

Keywords: P450 enzymes; oxidative metabolism; drug– drug interactions; exhepatic P450; bioactivation

Melatonin in Normal Physiology and Disease

edited by

Georges Maestroni

submission deadline 30 Jun 2024 | 3 articles | Viewed by 4639 | Submission Open

Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis

(This special issue belongs to the Section Molecular Biology)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications

edited by

Michele Scuruchi

submission deadline 30 Jun 2024 | 3 articles | Viewed by 4376 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Carbohydrates)

Feature Papers in the Natural and Bio-Inspired Molecules Section

edited by

Hang Fai (Henry) Kwok

submission deadline 30 Jun 2024 | 3 articles | Viewed by 3884 | Submission Open

(This special issue belongs to the Section Natural and Bio-inspired Molecules)

Sterol Biosynthesis and Function in Organisms

edited by Hubert Schaller

submission deadline 30 Jun 2024 | 4 articles | Viewed by 3571 | Submission Open

Keywords: sterol; biosynthesis; function; organisms

(This special issue belongs to the Section Molecular Biology)

Amyloid-Beta (Aβ) Production/Clearance Balance and Aβ Neurotoxicity in Alzheimer’s Disease: From Mechanisms to Therapy

edited by

Fumiaki Ito

and

Toshifumi Akizawa

submission deadline 30 Jun 2024 | 2 articles | Viewed by 2724 | Submission Open

Keywords: Alzheimer's disease; amyloid-beta (Aβ ); neurotoxicity of Aβ ; Aβ phagocytosis; Aβ clearance; autophagy-lysosome system; anti-Aβ monoclonal antibodies; catalytides

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Cancer Therapy Resistance

edited by

Majid Momeny

submission deadline 30 Jun 2024 | 1 articles | Viewed by 2661 | Submission Open

Keywords: cancer therapy resistance; genetic mutations in drug resistance; tumor microenvironment and therapy resistance; epigenetic mediators in drug resistance; cell signaling pathways in therapy failure; combination therapies

(This special issue belongs to the Section Molecular Medicine)

Vascular Disease and Thrombosis

edited by

Raffaele Serra

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1933 | Submission Open

Keywords: venous thromboembolism; superficial vein thrombosis; deep vein thrombosis; pulmonary embolism; post-thrombotic syndrome; ischemic heart disease; acute myocardial infarction; ischemic stroke; acute limb ischemia; intestinal infarction; biomarkers; hematologic disorders; thrombophilias

(This special issue belongs to the Section Molecular Medicine)

The Evolution and Function of Repetitive DNA

edited by Raquel Chaves and Sandra Louzada

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1864 | Submission Open

Keywords: repetitive DNA; satellite DNA; transposable elements; non-coding RNA transcripts; evolution of repetitive DNA; genome instability; genome evolution

(This special issue belongs to the Section Molecular Biology)

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)

edited by

David Lominadze

submission deadline 30 Jun 2024 | 2 articles | Viewed by 1859 | Submission Open

Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Biology)

Honorary Special Issue Dedicated to Prof. Giovanni Targher–the Metabolic Fatty Liver Syndromes: MASLD/MAFLD/NAFLD

edited by

Alessandro Mantovani

and

Amedeo Lonardo

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1550 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); metabolic associated fatty liver disease (MAFLD); nonalcoholic steatohepatitis (NASH); metabolic dysfunction-associated steatotic liver disease (MASLD); fatty liver

(This special issue belongs to the Section Biomacromolecules: Lipids)

The Role of Amyloid in Neurological Disorders

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1444 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid intraction

(This special issue belongs to the Section Biomacromolecules: Proteins)

New Insights into Cardiometabolic Diseases

edited by

Gundu H. R. Rao

and

Undurti N. Das

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1066 | Submission Open

Keywords: metabolic diseases; hypertension; obesity; type-2 diabetes; vascular diseases; acute vascular events

(This special issue belongs to the Section Molecular Medicine)

Research into Bioactive Natural Compounds: New Molecules, Bioinspired Syntheses, Biotechnological Methods and Bioassays—Celebrating the Pioneering Work of Prof. Alejandro Fernandez Barrero

edited by

José Francisco Quílez del Moral

and

Azucena González Coloma

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1063 | Submission Open

Keywords: natural products; bioactivity; organic synthesis; biotecnnology; structural elucidation

(This special issue belongs to the Section Natural and Bio-inspired Molecules)

Role of TRAF1 in Regulating Inflammation and Cell Survival

edited by Ali Abdul-Sater

submission deadline 30 Jun 2024 | 1 articles | Viewed by 949 | Submission Open

Keywords: TRAF1; inflammation; inflammasome; TNFRs; apoptosis; cellular survival

(This special issue belongs to the Section Biological Factors)

Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou

edited by

Christina Piperi

and

George D. Kalliolias

submission deadline 30 Jun 2024 | 1 articles | Viewed by 729 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Nutritional Deficiencies as a Driver of Inflammation: Molecular Mechanisms of Immune Defense

edited by

Franziska Roth-Walter

submission deadline 30 Jun 2024 | Viewed by 268 | Submission Open

Keywords: nutritional deficiencies; nutrients; minerals; cross feeding; microbes; inflammation; immune resilience; immune tolerance

(This special issue belongs to the Section Biological Factors)

Advances in CRISPR/Cas Systems for Genome Editing Applications in Biomedical Research

edited by

Alessandra Recchia

submission deadline 30 Jun 2024 | Viewed by 257 | Submission Open

Keywords: genome editing; CRISPR/Cas; gene therapy; cancer immunotherapy; diagnosis

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Stress- and Trauma-Related Disorders

edited by Vanessa Nieratschker

submission deadline 30 Jun 2024 | Viewed by 253 | Submission Open

Keywords: stress; trauma; epigenetics; genetics; molecular mechanisms; transgenerational transmission; neuronal adaptations; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Medicine)

The Role of Extracellular Matrix, Cell Membrane and Nuclear Involvement in Cellular Driven Mechanotransduction

edited by

Frederick H. Silver

submission deadline 30 Jun 2024 | Viewed by 238 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Epigenetics of Pulmonary Diseases

edited by

Narasaiah Kolliputi

submission deadline 30 Jun 2024 | Viewed by 215 | Submission Open

Keywords: asthma; mucus; chronic obstructive pulmonary disease; interstitial lung diseases; pulmonary arterial hypertension; acute lung injury; lung tuberculosis; pulmonary embolism; covalent modification; oxidative stress; DNA methylation; histone modification; noncoding RNAs; epigenetic regulation

(This special issue belongs to the Section Molecular Medicine)

The Role of Telomeres and Telomerase in Aging

edited by

Jun-Ping Liu

submission deadline 30 Jun 2024 | Viewed by 210 | Submission Open

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Diagnosis and Regulation of Mitochondrial Dysfunction

edited by

Cecilia Giulivi

submission deadline 30 Jun 2024 | Viewed by 171 | Submission Open

Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies

Sphingomonas: Metabolism and Use in Biotransformation of Biomolecules

edited by

Naglis Malys

and

Ernesta Augustinienė

submission deadline 30 Jun 2024 | Viewed by 165 | Submission Open

Keywords: Sphingomonas; bioremediation; polycyclic aromatic hydrocarbons; pesticides; organophosphates; polysaccharides; lignin; value-added compounds; microbial cell factories; gene engineering; synthetic biology; gene expression systems; mathematical modelling

The Role of Glia in Alzheimer's Disease

edited by

Sriram Balusu

submission deadline 30 Jun 2024 | Viewed by 148 | Submission Open

Keywords: Alzheimer's disease; neurodegeneration; glial cells

(This special issue belongs to the Section Molecular Medicine)

Human Gut Microbiome and Diet in Health and Diseases II

edited by

Luis Vitetta

submission deadline 30 Jun 2024 | Viewed by 141 | Submission Open

Keywords: gut microbiome; microbiota; nutrition; functional foods; mucosal immunity; dysbiosis

New Advances of Cannabinoid Receptors in Health and Disease

edited by

Balapal S. Basavarajappa

submission deadline 15 Jul 2024 | 6 articles | Viewed by 17365 | Submission Open

Keywords: neurodegeneration; alcohol; addiction; signaling; structure– function

(This special issue belongs to the Section Molecular Biology)

Novel Materials for Biomedical Applications II

edited by

Jayakumar Rajadas

and

Mustafeez Mujtaba Babar

submission deadline 15 Jul 2024 | 6 articles | Viewed by 11615 | Submission Open

Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering

(This special issue belongs to the Section Biological and Bio- Materials)

Learn from Machine Learning: The Identification of Biomarkers and Therapeutic Targets in Neurodegeneration

edited by

Haibo Wang

and

Chen Huang

submission deadline 15 Jul 2024 | 2 articles | Viewed by 3662 | Submission Open

Keywords: machine learning; neurodegeneration; biomarkers; therapeutic targets; data mining

(This special issue belongs to the Section Molecular Medicine)

Circular RNAs: Functions, Applications and Prospects II

edited by

William W. Du

and Feiya Li

submission deadline 15 Jul 2024 | 2 articles | Viewed by 2840 | Submission Open

Keywords: circular RNAs; circRNA; function; application; disease

(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)

Molecular Mechanisms of Human Skin Aging

edited by

Taihao Quan

submission deadline 15 Jul 2024 | 1 articles | Viewed by 1760 | Submission Open

Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention

New Insights into Neuroimmunology

edited by

Marc André Lécuyer

submission deadline 15 Jul 2024 | 1 articles | Viewed by 1748 | Submission Open

Keywords: neuroimmunology (in health and disease); multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); acute disseminated encephalomyelitis (ADEM); neuromyelitis optica spectrum disorders (NMOSD); transverse myelitis; anti-NMDA receptor encephalitis (NMDAR encephalitis); paraneoplastic autoimmune diseases; neurodegenerative diseases with immunological components; Parkinson’ s disease; Alzheimer’ s disease; neuroinfections

(This special issue belongs to the Section Cellular Biochemistry)

Transglutaminases: Regulation, Imaging, and Applications

edited by Thomas M. Jeitner

submission deadline 15 Jul 2024 | 1 articles | Viewed by 1101 | Submission Open

Keywords: imaging; regulation; application; clinical translation

(This special issue belongs to the Section Enzymology)

Conventional and In Silico-Based Approaches for the Optimization of Nanobody Biophysical Characteristics

edited by

Ario de Marco

submission deadline 15 Jul 2024 | 1 articles | Viewed by 853 | Submission Open

Keywords: nanobodies; modeling; screening strategies; random mutagenesis; rational engineering; expression conditions

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 15 Jul 2024 | 1 articles | Viewed by 817 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

Skeletal Muscle in Health, Exercise and Aging

edited by Barbara Munz

submission deadline 15 Jul 2024 | Viewed by 230 | Submission Open

Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Therapies of SARS-CoV-2

edited by

Grzegorz Przybylski

and Piotr Kopiński

submission deadline 15 Jul 2024 | Viewed by 145 | Submission Open

Keywords: ARDS in COVID-19; COVID-19 therapies; COVID-19 vaccines; immune systems in COVID-19; long-COVID pathogenesis; SARS-Cov-2 genomics; SARS-Cov-2 variants; T-cells in COVID-19

Complex Muscle Models

edited by Sonia Albini

submission deadline 15 Jul 2024 | Viewed by 125 | Submission Open

Keywords: muscular dystrophy; skeletal muscle; cardiac muscle; bioengineering; biomechanics; humanized models; pathophysiological; screening platform

(This special issue belongs to the Section Molecular Biology)

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