Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Wnt Pathway Regulation in Development, Stem Cells and Cancer
edited by Marc De La Roche
submission deadline 25 Apr 2025 | Viewed by 527 | Submission Open
Keywords: Wnt pathway regulation and function; metazoan development; stem cells; Wnt pathway driven cancer
(This special issue belongs to the Section Biological Factors)
Neurological Disorders: From Molecular Mechanisms to Therapy Strategies submission deadline 30 Apr 2025 | 11 articles | Viewed by 63025 | Submission Open
Keywords: neurodegeneration; neuroprotection; novel therapies; natural molecules
(This special issue belongs to the Section Molecular Biology)
Nutrition, Metabolism, and Obesity: Novel Strategies and Molecular Mechanisms—Future Perspectives
edited by
submission deadline 30 Apr 2025 | 9 articles | Viewed by 25773 | Submission Open
Keywords: diet; nutrients; obesity; inflammation; fat; glucose intolerance; insulin resistance; fatty liver disease; metabolic syndrome
(This special issue belongs to the Section Molecular Medicine)
Novel Insights into Autoimmune/Autoinflammatory Skin Diseases submission deadline 30 Apr 2025 | 8 articles | Viewed by 17281 | Submission Open
Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms Underlying Liver Diseases
edited by
submission deadline 30 Apr 2025 | 7 articles | Viewed by 16835 | Submission Open
Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights
(This special issue belongs to the Section Cellular Biochemistry)
Advances in β3-Adrenoceptor submission deadline 30 Apr 2025 | 4 articles | Viewed by 13722 | Submission Open
Keywords: β 3-adrenoceptor; cardiovascular diseases; cancer; prematurity; hypoxia/hyperoxia; neurodegenerative diseases; retinopathy
Recent Advances in Laccases and Laccase-Based Bioproducts submission deadline 30 Apr 2025 | 5 articles | Viewed by 13140 | Submission Open
Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering
(This special issue belongs to the Section Enzymology)
In Silico Drug Design and Discovery: Big Data for Small Molecule Design 2nd Edition submission deadline 30 Apr 2025 | 5 articles | Viewed by 11395 | Submission Open
Keywords: drug discovery; medicinal chemistry; chemoinformatics; bioinformatics; machine learning; deep learning
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Heart Diseases: Molecular Mechanisms and New Therapies
edited by Glen Pyle
submission deadline 30 Apr 2025 | 5 articles | Viewed by 8557 | Submission Open
Keywords: heart failure; heart disease; myocardial; molecular mechanisms; therapies
(This special issue belongs to the Section Molecular Medicine)
DNA Damage, Mutagenesis, and Repair Mechanisms
edited by , Sofie Lautrup and Péter Csaba Huszthy
submission deadline 30 Apr 2025 | 6 articles | Viewed by 8447 | Submission Open
Keywords: DNA repair; BER; NER; HR; NHEJ; A-EJ; MMR; DDR; TCR; aging
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Histone Deacetylase Research in Health and Disease
edited by and
submission deadline 30 Apr 2025 | 3 articles | Viewed by 7446 | Submission Open
Keywords: histone deacetylase; HDAC inhibitor; deacetylation; enzymatic and non-enzymatic activity; epigenetics; human disease
(This special issue belongs to the Section Enzymology)
Regulation of Notch Signaling Pathway and Its Relation to Diseases
edited by
submission deadline 30 Apr 2025 | 2 articles | Viewed by 6516 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Molecular Diagnosis and Regulation of Mitochondrial Dysfunction
edited by
submission deadline 30 Apr 2025 | 2 articles | Viewed by 6459 | Submission Open
Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies
(This special issue belongs to the Section Biological Factors)
Glial Cross-Talk in Central Nervous System Health and Disease submission deadline 30 Apr 2025 | 1 articles | Viewed by 5909 | Submission Open
Keywords: glial physiology; glial cross-talk in CNS homeostasis; glial cross-talk in neuroinflammation; glial cross-talk in CNS diseases
(This special issue belongs to the Section Molecular Biology)
Advances in Cellular Biophysics: Transport and Mechanics
edited by Boris Musset and
submission deadline 30 Apr 2025 | 4 articles | Viewed by 5568 | Submission Open
Keywords: membrane transport; ion transport; cellular biophysics; applied science; basic science
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Recent Trends in Kidney and Cardiovascular Diseases
edited by
submission deadline 30 Apr 2025 | 4 articles | Viewed by 5469 | Submission Open
Keywords: chronic kidney disease; cardiovascular risk; albuminuria; epidemiology; estimated glomerular filtration rate
(This special issue belongs to the Section Molecular Medicine)
Advances in Metabolites Produced by Microbiota submission deadline 30 Apr 2025 | 2 articles | Viewed by 5265 | Submission Open
Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins
(This special issue belongs to the Section Cellular Biochemistry)
Design and Synthesis of Bioactive Compounds for Therapeutic Applications submission deadline 30 Apr 2025 | 3 articles | Viewed by 4025 | Submission Open
Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Microbial Biocontrol and Plant-Microbe Interactions
edited by
submission deadline 30 Apr 2025 | 5 articles | Viewed by 3279 | Submission Open
Keywords: endophytic microbiome for disease management; plant– microbe interactions; plant– insect– pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response
(This special issue belongs to the Section Cellular Biochemistry)
Targeting Neuroinflammation and Insulin Resistance for a Healthy Brain: Prevention and Treatment of Neurological and Psychiatric Disorders submission deadline 30 Apr 2025 | 1 articles | Viewed by 2987 | Submission Open
Keywords: insulin receptor substrates; microglia; degenerative diseases; psychiatric disorders; nutrition
(This special issue belongs to the Section Molecular Medicine)
Biosynthesis and Function of Thyroid Hormones
edited by and Eva K. Wirth
submission deadline 30 Apr 2025 | 3 articles | Viewed by 2874 | Submission Open
Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements
(This special issue belongs to the Section Biological Factors)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 30 Apr 2025 | 1 articles | Viewed by 1437 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
Advances in Cancer and Glycosylation
edited by
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1436 | Submission Open
Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases
(This special issue belongs to the Section Molecular Medicine)
Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability
edited by
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1419 | Submission Open
Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Targets for Breast Cancer Therapy, 2nd Edition submission deadline 30 Apr 2025 | 1 articles | Viewed by 1399 | Submission Open
Keywords: breast cancer; molecular targets; signaling pathways; proliferation; survival; resistance; crosstalk
(This special issue belongs to the Section Molecular Medicine)
Plant-Microbe-Insect Interactions
edited by and Xueke Gao
submission deadline 30 Apr 2025 | 1 articles | Viewed by 850 | Submission Open
Keywords: plant– microbe– insect interactions; plant defense; insects; pest control; microbiology
(This special issue belongs to the Section Cellular Biochemistry)
Necrotic Cell Death Mechanisms and Therapies
edited by and
submission deadline 30 Apr 2025 | Viewed by 592 | Submission Open
Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis
(This special issue belongs to the Section Cellular Biochemistry)
Image-Guided Cancer Therapy
edited by
submission deadline 30 Apr 2025 | Viewed by 324 | Submission Open
Keywords: MRI; PET; CT; US; oncology; cancer immunotherapy
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 30 Apr 2025 | Viewed by 288 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
The Role of Alarmins and Innate Lymphoid Cells in Allergic Immune Responses
edited by Yasutomo Imai
submission deadline 30 Apr 2025 | Viewed by 243 | Submission Open
Keywords: innate lymphoid cells; biologics; alarmin; atopic dermatitis; psoriasis; asthma; food allergy; allergic conjunctivitis; allergic rhinitis
(This special issue belongs to the Section Molecular Biology)
Unveiling Molecular Pathways Involved in the Gut–Brain Axis in Autism
edited by and John Scott
submission deadline 30 Apr 2025 | Viewed by 227 | Submission Open
Keywords: neurodevelopment; autism; genetic; molecular pathways; gastrointestinal
(This special issue belongs to the Section Molecular Biology)
The Role of Extracellular Vesicles in Drug Delivery
edited by
submission deadline 30 Apr 2025 | Viewed by 186 | Submission Open
Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy
(This special issue belongs to the Section Molecular Biology)
New Insight into Subphases of DNA Replication in Mammalian Cells
edited by
submission deadline 30 Apr 2025 | Viewed by 169 | Submission Open
Keywords: DNA content; chromosomal aberrations; replication peaks; subphases of replication
(This special issue belongs to the Section Molecular Reproduction)
Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes submission deadline 1 May 2025 | 3 articles | Viewed by 6597 | Submission Open
Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity
(This special issue belongs to the Section Molecular Medicine)
Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 2nd Edition submission deadline 10 May 2025 | 5 articles | Viewed by 7162 | Submission Open
Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’ s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; SARS-CoV-2; spike protein; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics
(This special issue belongs to the Section Chemical Biology)
Cellular and Molecular Mechanism of Spermatogenesis
edited by Yanhe Lue
submission deadline 10 May 2025 | 3 articles | Viewed by 3927 | Submission Open
Keywords: spermatogenesis; regulation; biomolecules
(This special issue belongs to the Section Molecular Reproduction)
Protein Structure Prediction in Drug Discovery: 2nd Edition submission deadline 15 May 2025 | 4 articles | Viewed by 21393 | Submission Open
Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Skeletal Muscle Homeostasis and Regeneration
edited by
submission deadline 15 May 2025 | 6 articles | Viewed by 15196 | Submission Open
Keywords: skeletal muscle; homeostasis; regeneration; satellite cells; fiber type
(This special issue belongs to the Section Molecular Medicine)
Interface of Aging and Biomaterials: 2nd Edition
edited by
submission deadline 15 May 2025 | 3 articles | Viewed by 9820 | Submission Open
Keywords: aging; senescence; geroscience; biomolecules; biomaterials; biocompatibility; nanoparticles; hydrogels
(This special issue belongs to the Section Bio-Engineered Materials)
The Role of Arginine and Arginine Metabolites in Cerebro- and Cardiovascular Disease Targeted Therapy
edited by Edzard Schwedhelm, , Roman N. Rodionov and Ying Wang
submission deadline 15 May 2025 | 1 articles | Viewed by 2629 | Submission Open
Keywords: alanine:glyoxylate aminotransferase 2; asymmetric dimethylarginine; cyclic guanosine monophosphate; dimethylarginine dimythylaminohydrolase 1; homoarginine; nitric oxide; symmetric dimethylarginine
(This special issue belongs to the Section Molecular Medicine)
Role of Matrix Metalloproteinase in Health and Disease
edited by Ali A. Hussain
submission deadline 15 May 2025 | 3 articles | Viewed by 2558 | Submission Open
Keywords: matrix metalloproteinases (MMPs); regulatory aspects of MMPs; MMPs and tissue ageing; MMPs in diseases; MMPs as therapeutic targets
(This special issue belongs to the Section Molecular Medicine)
Novel Biomarkers of Kidney Diseases: Second Edition submission deadline 15 May 2025 | 1 articles | Viewed by 1532 | Submission Open
Keywords: biomarker; kidney disease; fibrosis; proteomics; metabolomics
(This special issue belongs to the Section Molecular Biomarkers)
Recent Developments in Biophysical Studies of Cell Membranes: Second Edition
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 2585 | Submission Open
Keywords: membrane biophysics; cell membranes; model cell membranes
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Tumour Suppressor Genes: The Guardians of Cell Integrity
edited by
submission deadline 20 May 2025 | 1 articles | Viewed by 1126 | Submission Open
Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy
(This special issue belongs to the Section Molecular Biology)
Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition
edited by
submission deadline 21 May 2025 | 2 articles | Viewed by 1823 | Submission Open
Keywords: tissue engineering; bioactive molecules; cellular function; proliferation
(This special issue belongs to the Section Bio-Engineered Materials)
Genetic and Structural Analyses of Coronaviruses: Insights into SARS-CoV-2 and Beyond
edited by
submission deadline 30 May 2025 | 4 articles | Viewed by 3747 | Submission Open
Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Advances in Neuroproteomics submission deadline 31 May 2025 | 8 articles | Viewed by 21266 | Submission Open
Keywords: discovery mass spectrometry; neuroproteomics; mass spectrometry; quantitative proteomics; targeted mass spectrometry
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Cancer Immunotherapy and the PD-1/PD-L1 Checkpoint Pathway submission deadline 31 May 2025 | 8 articles | Viewed by 13961 | Submission Open
Keywords: immunotherapy; biomarkers; PD-1/PD-L1
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Mechanism and Regulation of Lifespan and Aging
edited by Mark McCormick
submission deadline 31 May 2025 | 5 articles | Viewed by 12089 | Submission Open
Keywords: aging; lifespan; healthspan
(This special issue belongs to the Section Molecular Biology)
Tissue Calcification in Normal and Pathological Environments
edited by
submission deadline 31 May 2025 | 5 articles | Viewed by 11488 | Submission Open
Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death
(This special issue belongs to the Section Molecular Medicine)
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