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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

and Soraia Katia Pereira Costa

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1139 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Advances in Plasma Bioscience and Medicine: 2nd Edition

edited by

Yuantao Zhang

and

Maksudbek Yusupov

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1117 | Submission Open

Keywords: non-thermal (cold) atmospheric pressure plasma; reactive oxygen and nitrogen species (RONSs); plasma– biomolecule interactions; plasma cancer treatment; plasma immunomodulation; plasma inactivation of viruses; fungi and bacteria; plasma– liquid interactions; computer simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Biochemistry of Wine and Beer, 3rd Edition

edited by

Encarna Gómez-Plaza

and

Rocio Gil-Muñoz

submission deadline 30 Aug 2025 | 4 articles | Viewed by 4485 | Submission Open

Keywords: grape biochemistry; barley and malt biochemistry; role of prefermentative enzymatic reactions; wine and beer’ s fermentation process; aging reactions; phenolic compounds; aroma compounds; protein and nitrogen compounds

(This special issue belongs to the Section Biological Factors)

Bioactive Molecules: Structures, Functions and Potential Uses for Cancer Prevention and Targeted Therapies (2nd Edition)

edited by

Qingping Dou

submission deadline 31 Aug 2025 | 10 articles | Viewed by 23759 | Submission Open

Keywords: small molecules; biomolecules; molecular targeting; natural products; cancer management

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Esophageal Diseases: Molecular Basis and Therapeutic Approaches

edited by

Hiroshi Nakagawa

and Amanda B. Muir

submission deadline 31 Aug 2025 | 6 articles | Viewed by 12602 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

State-of-the-Art of Myology 2024–2025

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 11425 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants

edited by

Antonio Evidente

and

Stefano Superchi

submission deadline 31 Aug 2025 | 5 articles | Viewed by 8826 | Submission Open

Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Diet and Immune Response

edited by

Hanne Frøkiær

submission deadline 31 Aug 2025 | 5 articles | Viewed by 7229 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Nanomaterials and Their Applications in Biomedicine

edited by

George Pasparakis

submission deadline 31 Aug 2025 | 5 articles | Viewed by 7066 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

The Role of Astrocytes in Neurodegenerative Diseases

edited by

Nima Sanadgol

submission deadline 31 Aug 2025 | 4 articles | Viewed by 5925 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

Diabetic Retinopathy: From Pathophysiology to Therapeutic Perspectives

edited by Annayya R. Aroor,

Puttur Santhoshkumar

and Dean P. Hainsworth

submission deadline 31 Aug 2025 | 2 articles | Viewed by 5783 | Submission Open

Keywords: diabetic retinopathy; microvascular injury; neuronal dysfunction; mitochondrial dysfunction; oxidative stress; inflammation; biomarkers; signaling pathways; pharmacological interventions; anti-vegf; gene therapy; stem cell-based therapies; prevention strategies; patient education programs; patient-centered care

(This special issue belongs to the Section Molecular Medicine)

Chemoinformatics and Molecular Modeling of Pharmacologically Active Biomolecules: A Themed Issue in Honor of Prof. José L. Medina-Franco

edited by Carlos A. Velázquez-Martínez and

Martín González-Andrade

submission deadline 31 Aug 2025 | 1 articles | Viewed by 5033 | Submission Open

Keywords: drug design; molecular modelling; chemoinformatics; materials science; big data; machine learning; predictive modeling; toxicology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Intracerebral Hemorrhage: Advances in Preclinical Studies: 2nd Edition

edited by

Sangeetha Sukumari-Ramesh

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4733 | Submission Open

Keywords: neuroinflammation; oxidative stress; neurodegeneration; neurological deficits; blood– brain barrier damage

(This special issue belongs to the Section Molecular Medicine)

The Role of CD36 in Human Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 3192 | Submission Open

Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Molecular Medicine)

New Insights into Forensic Molecular Genetics

edited by

Erin K. Hanson

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2997 | Submission Open

Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2729 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action

edited by Chandra Mishra and

Dnyaneshwar N. Garad

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2708 | Submission Open

Keywords: heterocyclic compounds; anticancer; synthetic; natural

(This special issue belongs to the Section Molecular Medicine)

Genomics in Biodiversity Conservation (Vertebrates and Invertebrates)

edited by

Shantanu Kundu

and

Hyun-Woo Kim

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2700 | Submission Open

Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution

(This special issue belongs to the Section Molecular Genetics)

Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs

edited by Tatiana V. Lipina

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2627 | Submission Open

Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R; neurodevelopment; neurotransmission; synaptic plasticity; neural circuits; genomics; proteomics; intracellular signalling; bioenergetics; prevention

(This special issue belongs to the Section Molecular Biology)

New Insights into RNA-Binding Proteins

edited by

Marko Noerenberg

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2432 | Submission Open

Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Nerve Conduction Inhibition to Alleviate Disease Symptoms: Clinical Drugs and Medicinal Plant Compounds

edited by

Eiichi Kumamoto

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2417 | Submission Open

Keywords: nerve conduction; action potential; clinical drug; medicinal plant compound; voltage-gated ion channel

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1662 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds as Modifiers of Mitochondrial Function

edited by Mihail "Mike" Mitov

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1201 | Submission Open

Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)

(This special issue belongs to the Section Natural and Bio-derived Molecules)

New Insights into Autacoids in Disease

edited by

Katsutoshi Yayama

submission deadline 31 Aug 2025 | Viewed by 1035 | Submission Open

Keywords: angiotensin; bradykinin; endothelin; prostaglandins; thromboxanes; leukotrienes; serotonin; histamine; angiotensin-converting enzyme; angiotensin receptor; renin; kininogen; kallikrein; cyclooxygenase; phospholipase A2

(This special issue belongs to the Section Molecular Medicine)

Probiotics and Their Metabolites, 2nd Edition

edited by

Hary Razafindralambo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 916 | Submission Open

Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition

edited by

Michele Scuruchi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 829 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Applications of NMR Spectroscopy in Structure-Based Drug Discovery

edited by Alexander L. Breeze and Reto Walser

submission deadline 31 Aug 2025 | Viewed by 509 | Submission Open

Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases

edited by Ricardo Rodrigues

submission deadline 31 Aug 2025 | Viewed by 345 | Submission Open

Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases

(This special issue belongs to the Section Molecular Biology)

Biomolecular Sciences and Precision Medicine in Vascular Disease

edited by

Raffaele Serra

submission deadline 31 Aug 2025 | Viewed by 297 | Submission Open

Keywords: precision medicine; vascular disease; vascular surgery

(This special issue belongs to the Section Molecular Medicine)

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 31 Aug 2025 | Viewed by 205 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Chemical Biology)

Small Aquatic Organisms as a Model for Predictive Toxicology and Stress Mechanisms

edited by Tetsuhiro Kudoh

submission deadline 31 Aug 2025 | Viewed by 141 | Submission Open

Keywords: fish model; zebrafish model; chemical toxicology

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 31 Aug 2025 | Viewed by 128 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

Advances in Antiviral Drug Development

edited by Angel S. Galabov

submission deadline 31 Aug 2025 | Viewed by 106 | Submission Open

Keywords: viral inhibitors; mechanism of action; antiviral tests

(This special issue belongs to the Section Molecular Medicine)

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Aug 2025 | Viewed by 95 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

edited by

Yuping Bao

and

Jessica M. Larsen

submission deadline 15 Sep 2025 | 1 articles | Viewed by 3126 | Submission Open

Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy

(This special issue belongs to the Section Bio-Engineered Materials)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models

edited by

Sihong Song

submission deadline 15 Sep 2025 | 2 articles | Viewed by 2663 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases

edited by Kristina Seiffert-Sinha and Animesh A. Sinha

submission deadline 15 Sep 2025 | Viewed by 399 | Submission Open

Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Bioactive Compounds from Microalgae

edited by

Giuseppe Martelli

and

Rosa Paola Radice

submission deadline 15 Sep 2025 | Viewed by 113 | Submission Open

Keywords: microalgae; bioactive compounds; biomolecules; innovations

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Dysregulated Cytokine Signals in Human Disease

edited by

Alister C. Ward

submission deadline 25 Sep 2025 | Viewed by 346 | Submission Open

Keywords: cytokine; signaling; dysregulation; immunity; development; disease

(This special issue belongs to the Section Molecular Medicine)

Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies

edited by

Othmar Moser

and

Harald Sourij

submission deadline 30 Sep 2025 | 8 articles | Viewed by 25385 | Submission Open

Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy

(This special issue belongs to the Section Molecular Medicine)

Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience

edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim

submission deadline 30 Sep 2025 | 10 articles | Viewed by 24489 | Submission Open

Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology

(This special issue belongs to the Section Molecular Biology)

Prebiotics and Probiotics in Health and Disease: Looking at the Future

edited by

Pio Maria Furneri

Virginia Fuochi

and

Giovanna Furneri

submission deadline 30 Sep 2025 | 8 articles | Viewed by 20116 | Submission Open

Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics

(This special issue belongs to the Section Molecular Medicine)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 30 Sep 2025 | 6 articles | Viewed by 17283 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)

edited by

David Lominadze

submission deadline 30 Sep 2025 | 7 articles | Viewed by 12595 | Submission Open

Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Neuropathology of Alzheimer's Disease

edited by

Venkata Atluri

and

Fanpeng Zhao

submission deadline 30 Sep 2025 | 7 articles | Viewed by 12340 | Submission Open

Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity

(This special issue belongs to the Section Molecular Medicine)

Amyloid-Beta and Alzheimer’s Disease

edited by

Fumiaki Ito

and

Toshifumi Akizawa

submission deadline 30 Sep 2025 | 6 articles | Viewed by 11078 | Submission Open

Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System

edited by Peng Yao and

Wei Guo

submission deadline 30 Sep 2025 | 5 articles | Viewed by 7985 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Medicine)

The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research

edited by Riccardo Fesce

submission deadline 30 Sep 2025 | 1 articles | Viewed by 6870 | Submission Open

Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Health and Environmental Effect of Advanced Materials and Fine Particles: 2nd Edition

edited by

Il Je Yu

submission deadline 30 Sep 2025 | 1 articles | Viewed by 5896 | Submission Open

Keywords: advanced materials; fine particles; nanoparticles; nanomaterials; ultrafine particles; health effect; environmental effect; risk assessment; toxicity; exposure; biomaterials

(This special issue belongs to the Section Molecular Medicine)

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