Protein Misfolding Diseases: Molecular Mechanisms and Therapeutic Strategies
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Structure and Dynamics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 75
Special Issue Editors
Interests: protein aggregation; protein misfolding; biomolecular condensation; chemical kinetics; cellular homeostasis; small molecules; antibody therapeutics; drug discovery; neurodegeneration; neurodegenerative diseases
Interests: protein aggregation; protein misfolding; biomolecular condensation; chemical kinetics; cellular homeostasis; small molecules; antibody therapeutics; drug discovery; neurodegeneration; neurodegenerative diseases
Special Issue Information
Dear Colleagues,
Misfolded proteins and their isoforms are increasingly being recognized as cytotoxic agents over a wide range of human disorders associated with protein aggregation and biomolecular condensate formation. These disorders, including Alzheimer's and Parkinson's diseases, type II diabetes, and amyotrophic lateral sclerosis, among others, are increasingly prevalent and profoundly debilitating. Recent years have witnessed extensive mechanistic investigations, both in vitro and in vivo, leading to the proposal of various therapeutic strategies. These approaches aim at restoring protein and cellular homeostasis through interventions utilizing natural products, small molecules, antibodies, or human metabolites. This Special Issue will cover some of the most advanced developments in this field, ranging from mechanistic in silico studies, to bench science, method development, and pre-clinical studies.
Dr. Priyanka Joshi
Dr. Michele Perni
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein aggregation
- protein misfolding
- biomolecular condensation
- chemical kinetics
- cellular homeostasis
- small molecules
- antibody therapeutics
- drug discovery
- neurodegeneration
- neurodegenerative diseases
