Glutamate and Glutamate Receptors in Health and Diseases, Second Edition
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 28 February 2025 | Viewed by 13
Special Issue Editors
Interests: pharmacology; central nervous system; addiction; pain; learning and memory; anxiety; depression; glutamate receptors
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacology; central nervous system; memory; addiction; glutamate; metabotropic glutamate receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The history of glutamate as a neurotransmitter began with T. Hayashi in 1952 when he reported that glutamate injections into dog cerebral ventricles induced seizures. Since then, it has become clear that glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) and is essential for proper neuronal development, synaptic plasticity, and learning and memory. It acts through the activation of glutamate receptors that are subdivided into the following two classes: ionotropic receptors, which act as ion channels (AMPA, NMDA, and kainate receptors), and metabotropic receptors (mGluRs), which belong to the GPCRs that modulate the cascades of intracellular second messengers. Disturbances in glutamatergic function have been implicated in the pathophysiology of several neuropsychiatric disorders, including schizophrenia, drug abuse and addiction, autism, and depression, as well as in neurodegenerative diseases that were until recently poorly understood.
This Special Issue aims to collect research papers and reviews that focus on the role of glutamate or its receptors in CNS diseases. The intent is to provide novel mechanistic insights into the function of glutamate and glutamate receptors and their translational value for human diseases. We hope that this research can identify new potential pharmacological targets for therapy.
Prof. Dr. Jolanta H. Kotlińska
Dr. Marta Marszalek-Grabska
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glutamate receptors
- addiction
- pain
- learning and memory
- anxiety
- depression
- autism
- neurodegeneration
