Protein Aggregation—Accident, Threat or Organized Assembly?
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: 15 March 2025 | Viewed by 238
Special Issue Editor
Interests: protein structure and function; protein folding; protein-protein interactions; protein dynamics; type III secretion system; bacterial pathogens; non-coding RNA structure; protein overexpression
Special Issue Information
Dear Colleagues,
Most cellular processes are thought to be coordinated by supramolecular assemblies of well-folded proteins interacting accurately and specifically with one another. When this assembly loses its specificity, mostly comprises a single protein component, is often misfolded, and exhibits limited solubility, it is characterized as aggregation. Protein aggregation is implicated in the pathology of several diseases (e.g., amyloid formation in neurodegenerative diseases). It can result from the overexpression of proteins and potentially act as a protective measure against undesirable, aberrant, or toxic proteins in bacteria (inclusion bodies), but it could also represent a method of compartmentalizing cellular processes in membrane-less “phase-separated” organelles. This Special Issue aims to illuminate this “dark side” of protein intracellular assembly at the biochemical/biophysical level as well as the cellular and organismal level.
Submissions of both original research and review articles are welcome. Manuscripts focusing on the mechanistic aspects of protein aggregation and subcellular localization and organization are particularly encouraged.
Dr. Efstratios Mylonas
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein aggregation
- protein misfolding
- amyloids
- inclusion bodies
- phase separation
