Prognostic and Predictive Biomarkers for Reactive Oxygen Species Related Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 660
Special Issue Editor
Interests: protein purification; protein tyr-phosphorylation and dephosphorylation; inflammatory and metabolic dìseases; oxidative stress; eryptosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Mitochondria, xanthine oxidase, uncoupled nitric oxide synthases and NADPH oxidase are only a part of the main sources of reactive oxygen species (ROS), which can influence post-translational modifications and alter cellular functions, leading to cell dysfunction, necrosis or apoptosis. Oxidative stress, related to unbalanced ROS homeostasis, can directly affect the redox status of different molecules, such as proteins, lipids, and nucleic acids, limiting their availability and functionality. At the same time, OS can also disturb their expression levels, such as, for example, through the expression of microRNAs which can regulate the expression of redox sensors, alter critical components of the cellular antioxidants, interact with the proteasome, and influence the systems of DNA repair.
What leads to OS can result from different pathologies, in the form of an uncontrolled response to invading pathogens or endogenous signals.
This Special Issue of Biomolecules aims to explore new biomarkers for the monitoring of patient overall outcomes together with identification and characterization of potential targets of therapeutic interventions in pathologies related to an increased ROS production.
Dr. Luciana Bordin
Guest Editor
Manuscript Submission Information
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Keywords
- Inflammatory and infectious diseases
- Mitochondrial DNA
- Micro RNA
- Redox regulation
- Cell signaling
