Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 15 November 2024 | Viewed by 101
Special Issue Editors
Interests: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin
Special Issue Information
Dear Colleagues,
Autoimmune bullous diseases are a group of skin disorders that are thought to result from an autoantibody attack against intercellular adhesion molecules or components of the basement membrane in the skin as well as mucosal surfaces. While they are clinically and immunopathologically heterogenous, they are all associated with a high degree of morbidity and occasional mortality both from untreated disease in itself as well as mainly from their immunosuppressive treatment. In light of the success of anti-CD20 therapy, there has been a recent surge of clinical trials in this field with an aim of reducing autoantibodies, but outcomes have been underwhelming thus far, highlighting the need to focus again on the basic mechanisms of these diseases on the cellular and molecular levels.
The aim of this Special Issue is to delve into the cellular and molecular aspects of autoimmune bullous diseases and to link genomic and proteomic data with clinical outcomes. We are interested in in vitro, in vivo, and pre-clinical studies from genetics and gene expression, cellular immune responses (both in the peripheral blood as well as in target tissues), proteomics to the mechanisms of acantholysis or the loss of keratinocyte cell adhesion. We also encourage reviews that summarize the state of the art in disease pathogenesis and mechanisms of target damage.
We look forward to receiving your contributions.
Dr. Kristina Seiffert-Sinha
Dr. Animesh A. Sinha
Guest Editors
Manuscript Submission Information
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Keywords
- autoimmunity
- blistering
- gene expression
- immunome
- keratinocyte
- pathomechanism
- proteome
- skin
