Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 29
Special Issue Editors
Interests: aging; skeleton; muscles; physical activity and wellness; cognitive perception; sport training; quality of life
Special Issues, Collections and Topics in MDPI journals
Interests: muscle atrophy; skeleton; bone; musculoskeletal diseases; physiology; exercise; neurodegeneration; aging
Interests: exercise; aging; whole body vibration; musculoskeletal diseases; osteoporosis; sarcopenia; neurodegeneration; quality of life
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Skeletal muscle is one of the most extensive tissues in the human body and plays a crucial role in maintaining health, contributing to bodily functions such as locomotion and energy metabolism regulation. Numerous factors, such as lifestyle and age, can have a significant impact on skeletal muscle metabolism, compromising mitochondrial function, satellite cell activity, multinucleated fibre formation, and numerous other processes underlying muscle physiology. Impaired muscle health could have systemic repercussions, as evidence indicates the existence of muscle–multiorgan crosstalk, in which an extensive network of molecular factors promotes biochemical communication between muscle and other organs. Similarly, diseases affecting the bones, brain, or intestines can have a devastating impact on muscle health, leading to atrophy and predisposing individuals to a sedentary lifestyle. However, the identity and role of the numerous molecular factors involved in muscle–multiorgan crosstalk, which is crucial for the balance between muscle health and disease, remain partially unexplored, suggesting the need to deepen our knowledge in this field of research. The identification of biomarkers or potential molecular targets could facilitate the development of strategies to counteract the musculoskeletal decline that occurs during ageing. Therefore, this Special Issue aims to collect original research articles or review articles investigating the molecular factors involved in skeletal muscle health and disease states.
Dr. Virginia Tancredi
Dr. Roberto Bonanni
Dr. Ida Cariati
Guest Editors
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Keywords
- skeletal muscle
- ageing
- muscle physiology
- muscle-multiorgan crosstalk
- muscle health
- muscle atrophy
- molecular factors
- sedentariness
- exercise
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