Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 16 May 2026 | Viewed by 36
Special Issue Editors
Interests: neutrophil; protease; matrikine; tissue remodeling in inflammatory lung diseases; COPD; cystic fibrosis; acute respiratory distress syndrome; autoimmune disease and tumor
Special Issues, Collections and Topics in MDPI journals
Interests: neutrophil-mediated inflammation; neutrophil migration and activation; protease; matrikine; airway remodeling in inflammatory lung diseases; COPD; chronic bronchitis; cystic fibrosis; cholinergic signaling; airway epithelial-mediated mucosal defenses; environmental toxins; autoimmune disease
Special Issue Information
Dear Colleagues,
Neutrophils are the most abundant leukocytes in human circulation and serve as first responders in the innate immune system. Their roles extend far beyond microbial defense, encompassing tissue remodeling, immune regulation, and involvement in a wide spectrum of diseases. This Special Issue aims to provide a comprehensive overview of current advances in neutrophil biology, highlighting their multifaceted roles in health and disease.
We invite original research articles, reviews, and perspectives that explore the following:
- Neutrophil development, differentiation, and lifespan regulation;
- Neutrophil heterogeneity and functional plasticity;
- Mechanisms of neutrophil activation, migration, and effector functions;
- Neutrophil extracellular traps (NETs) and their implications in pathology;
- Neutrophils in infectious diseases, including bacterial, viral, and fungal infections;
- Neutrophils in chronic inflammation and autoimmune disorders;
- Neutrophil involvement in cancer progression and tumor microenvironment;
- Neutrophil dysfunction in metabolic and cardiovascular diseases;
- Technological advances in neutrophil profiling (e.g., single-cell, omics, imaging);
- Therapeutic strategies targeting neutrophils or their pathways.
This Special Issue seeks to bridge basic science and clinical research, fostering interdisciplinary dialogue and encouraging translational insights that may lead to novel diagnostics and therapies.
Dr. Xin Xu
Dr. Lawrence Rasmussen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neutrophils
- immune regulation
- inflammation
- infectious diseases
- autoimmune disease
- tumor
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