Membrane Proteins Structure and Dynamics
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 440
Special Issue Editor
Interests: membrane proteins; potassium channels and toxin inhibitors; intrinsically disordered proteins; protein-protein interactions; biomolecular nuclear magnetic resonance; biochemistry and biophysics
Special Issue Information
Dear Colleagues,
Cellular homeostasis requires maintaining a closely controlled environment that is optimal for function and, therefore, cells are surrounded by a hydrophobic barrier comprised of tail-to-tail lipidic bilayers with hydrophilic head groups facing the intra- and extracellular surroundings. Biological communication with the environment is mediated by membrane-associated proteins (MPs), responsible for a range of important cellular processes, including signaling, recognition, and transport of ions and nutrients. MPs are unique in that, being embedded in the membrane, the majority of their exposed surface is hydrophobic in nature, and they must be studied natively or transferred into a stabilizing membrane-mimicking assembly. The research community thus faces a conundrum in which this important class of proteins—comprising over 30% of all expressed proteins in the human genome and the target of 50% of all approved pharmaceuticals—is notoriously resistant to biochemical and biophysical investigations.
This state of affairs has prioritized research providing structural and/or mechanistic information on the biology of MPs and their interactions with biological and synthetic modulators of their function. This Special Issue “Membrane Protein Structure and Dynamics” will focus on studies employing a wide range of experimental methods to characterize the behavior of MPs, their interactions with the surrounding membrane and cellular and external stimuli, as well as methodological approaches aimed at improving our ability to investigate MPs. Original manuscripts addressing these themes are most welcome.
Prof. Dr. Jordan Chill
Guest Editor
Manuscript Submission Information
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Keywords
- membrane protein
- surrogate membrane
- membrane–protein–ligand interactions
- membrane dynamics
- protein structure and function
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