Reelin, a Hub Protein during Nervous System Development? Volume II
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 140
Special Issue Editor
Interests: prefrontal cortex; postnatal maturation; adolescent vulnerability; reelin; extracellular matrix; synaptic plasticity; pathophysiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Reelin is a prominent brain extracellular matrix glycoprotein linked to an extensive signaling complex. Since its discovery and the description of a link between its homozygous loss-of-function mutation and a severe neurological phenotype characterized by a reeling gait in affected mice, reelin has come to be understood as a multifunctional protein and a psychiatric risk factor.
An important contributor at different stages of brain development, reelin is present during embryogenesis as well as postnatal maturation, and plays a role in the physiology of the adult central nervous system. Reelin has recently been found to be highly sensitive to environmental and chronic stressors that lead to dramatic alterations in expression levels. These significant changes in reelin expression and, consequently, reelin-mediated signaling pathways could constitute important triggers of neuropsychiatric disorders.
At the crossroads between cellular properties and physiological functions, this Special Issue aims to gather the latest findings on reelin signaling and function in the normal and pathological development of the central nervous system during both pre- and postnatal life. It will present original studies at the cellular or neural network level that include multiscale approaches (structural, functional, and behavioral) as well as reviews. It will also encourage studies on the molecular mechanisms associated with reelin signaling and the cellular pathways involved in reelin-mediated pathological brain development.
Dr. Pascale Chavis
Guest Editor
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Keywords
- prenatal development
- postnatal maturation
- physiology
- migration
- circuitry
- cellular pathways
- signal transduction
- psychiatric and cognitive disorders
- neurodevelopmental disorders
Related Special Issue
- Reelin, a Hub Protein during Nervous System Development? in Biomolecules (3 articles)
