Potential Therapeutic Value of Thrombospondin-1: A Multi-Factorial Mediator in Cardiovascular/Endothelial Pathologies
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 301
Special Issue Editors
2. Biomedical Sciences, College of Graduate Studies (CGS), Glendale, AZ 85308, USA
3. Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ 23617, USA
Interests: nanomedicine; targeted delivery; cardiovascular/cancer/inflammatory therapeutics and diagnostics; nutraceuticals; pharmaceutical formulations; nano-bioengineering
Special Issues, Collections and Topics in MDPI journals
2. Biomedical Sciences, College of Graduate Studies (CGS),19555 N59th Avenue, Glendale, AZ 85308, USA
Interests: thrombospondin 1-associated pathophysiology and pharmacological strategy; new drug targets in GPCR-mediated signaling pathways; vascular and microvascular pathology and pharmacology; cardiovascular pharmacotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Thrombospondin-1 (TSP1) is a prototypic member of the extracellular matrix protein family. In healthy subjects, TSP1 is maintained low in circulation. In contrast, TSP1 has been found substantially elevated in cardiovascular disease, metabolic syndrome-induced cardiovascular and renal complications, and pulmonary hypertension.
The domain mapping of TSP1 reveals a broad interaction network of 83 ligands and receptors, including cell surface bound receptors (namely CD47 and CD36), growth factors (VEGFA and PDGFβ), cytokines (TGFβ) and proteases (thrombin and MMP2). Studies have shown that TSP1 induces multifaceted actions through different ligands and receptors.
The main goal of this Special Issue is to serve as an open forum where researchers may share their recent findings, evaluation, and expert opinions in TSP1 pathologies in various organs, including but not limited to the kidney, lung, heart, and brain. Of particular interest, this issue will highlight the significance of TSP1 as a key therapeutic target molecule underlying vascular endothelial abnormalities.
We invite articles, in the form of original research or reviews, covering all aspects involving TSP1, from mechanistic findings underlying cardiovascular/endothelial pathologies to characterize and evaluate TSP1 as a novel therapeutic target or platform. Furthermore, this issue aims to present and discuss the current advancement in preclinical and clinical pharmaco-therapeutic strategies involving TSP1 and highlight their potential enhancements of current medical approaches.
Prof. Dr. Tamer Elbayoumi
Dr. Molly (Mingyi) Yao
Guest Editors
Manuscript Submission Information
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Keywords
- thrombospondin 1 (TSP1)
- endothelium injury/damage
- endothelium dysfunction
- vascular/microvascular remodeling
- angiogenesis
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