Obesity, Adipose Tissue and Cardiovascular Diseases (Second Edition)
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 30 November 2024 | Viewed by 56
Special Issue Editor
Interests: adipose tissue; cardiovascular disease; mitochondria; obesity; PCSK9
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity is a major health problem worldwide. The energy imbalance between calories consumed (intake of foods rich in fat and sugars) and calories expended (sedentary lifestyle) contributes to this. Obesity is associated with several comorbidities, such as impaired glucose metabolism, hypertension, dyslipidemia and atherosclerosis, as well as a rise in the risk of cardiovascular diseases (CVDs). In this context, the mechanisms behind obesity and CVDs are not fully understood, but adipose tissue could be an important factor. Obesity leads to structural changes in adipose tissue and affects its cellular composition. Adipose tissue, considered a dynamic depot, secretes bioactive molecules—namely adipokines. In obesity, dysfunctional adipose tissue is characterized by chronic, low-grade inflammation alongside increased secretion of pro-inflammatory adipokines and cytokines, which affect the cardiovascular system either directly or indirectly. Other important aspects of the link between obesity and CVDs include increases in fat mass as well as changes in the quality of adipose tissue, which can present reduced capillarization, microvascular dysfunction, endothelial cell activation and fibrosis. Finally, ectopic fat deposition (e.g., in the liver, heart and skeletal muscles) increases the risk of CVDs. Overall, original manuscripts and reviews that contribute to understanding novel molecular mechanisms or to identifying links between obesity, adipose tissue and CVDs are welcome.
Dr. Chiara Macchi
Guest Editor
Manuscript Submission Information
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Keywords
- obesity
- cardiovascular diseases (CVDs)
- hypertension
- dyslipidemia
- atherosclerosis
- adipose tissue
- adipokines
- cytokines
