Stem Cells Therapy for Ischemic Stroke
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 404
Special Issue Editors
Interests: traumatic brain injury; brain tumors; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With its high morbidity and mortality, ischemic stroke is the most common kind of brain injury and always results in severe neurological deficits. Despite advances in medical and surgical interventions, post-stroke therapies remain tough for clinical patients. Currently, the transplantation of stem cells derived from several tissue sources has been recognized as a very promising therapy for ischemic stroke, including neural stem cells (NSCs), mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPS cells). Furthermore, several clinical trials on stem cell therapy for ischemic stroke have been ongoing.
Upon an ischemic stroke attack, oxidative stress and inflammatory response are two early events in the biological cascade of brain injury. These two events mutually interact and directly trigger the process of autophagy. Appropriate autophagy can contribute to brain recovery by reducing the oxidative stress and inflammatory response, whereas autophagy dysfunction aggravates brain injury. Studies demonstrated that stem cells could exert their therapeutic role for brain injury in the following aspects: cellular replacement, secreting neurotrophic factors and mitochondrial transfer.
Therefore, we are launching this Special Issue of the journal Biomolecules, to discuss the recent progress in stem cell therapy for brain injury. These papers will especially elucidate relevant mechanisms in terms of oxidative stress, mitochondrion dysfunction and autophagy. The scope of our journal is mainly focused on basic science, in vitro, in vivo and pre-clinical research, while purely clinical studies are usually not processed. Original articles and review papers are welcome for submission to this issue.
Dr. Hailiang Tang
Dr. Lei Huang
Guest Editors
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Keywords
- stem cell
- brain injury
- ischemic stroke
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