Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 25 Jun 2026 | 3 articles | Viewed by 14750 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Intercellular Communication in Differentiation
edited by
submission deadline 25 Jun 2026 | Viewed by 632 | Submission Open
Keywords: intercellular communication; cellular differentiation; transcription factors; signaling hormone molecules
Pulmonary Fibrosis: From Molecular Mechanism to Therapeutic Targets
edited by Santosh Yadav, Muralidharan Anbalagan and Renat Shaykhiev
submission deadline 25 Jun 2026 | Viewed by 304 | Submission Open
Keywords: idiopathic pulmonary fibrosis; DNA damage response; senescence; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Medicine)
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 26 Jun 2026 | 6 articles | Viewed by 5595 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 26 Jun 2026 | 2 articles | Viewed by 1975 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases
edited by , and Arun Raja
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1185 | Submission Open
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology
(This special issue belongs to the Section Chemical Biology)
Spotlight on Hot Cancer Biological Biomarkers submission deadline 30 Jun 2026 | 4 articles | Viewed by 13512 | Submission Open
Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology
(This special issue belongs to the Section Molecular Biomarkers)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 30 Jun 2026 | 4 articles | Viewed by 11296 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease
edited by
submission deadline 30 Jun 2026 | 6 articles | Viewed by 10545 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
Polyphosphate (PolyP) in Health and Disease
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 6455 | Submission Open
Keywords: polyphosphate; polyP; biomarker and therapeutic target
(This special issue belongs to the Section Natural and Bio-derived Molecules)
New Insights into Protein Aggregation in Condensed and Amyloid States submission deadline 30 Jun 2026 | 3 articles | Viewed by 6309 | Submission Open
Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 30 Jun 2026 | 4 articles | Viewed by 6134 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Jun 2026 | 6 articles | Viewed by 6091 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 30 Jun 2026 | 2 articles | Viewed by 4900 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Mitochondria as a Target for Tissue Repair and Regeneration
edited by
submission deadline 30 Jun 2026 | 3 articles | Viewed by 4177 | Submission Open
Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy
(This special issue belongs to the Section Molecular Biology)
New Insights into Stem Cell-Derived Exosomes in Human Health and Disease
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 4133 | Submission Open
Keywords: stem cells; exosomes; regenerative medicine; diagnostics
(This special issue belongs to the Section Cellular Biochemistry)
Lipid Signaling in Human Disease
edited by and Felicity Ashcroft
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3954 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application submission deadline 30 Jun 2026 | 3 articles | Viewed by 3913 | Submission Open
Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders
(This special issue belongs to the Section Biological Factors)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3743 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
(This special issue belongs to the Section Biological Factors)
Molecular Basis and Novel Treatment of Epilepsy
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3551 | Submission Open
Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research
(This special issue belongs to the Section Molecular Biology)
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2994 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications submission deadline 30 Jun 2026 | 1 articles | Viewed by 2652 | Submission Open
Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine
(This special issue belongs to the Section Cellular Biochemistry)
Immune Response to Allergens submission deadline 30 Jun 2026 | 2 articles | Viewed by 2493 | Submission Open
Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2256 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Jun 2026 | Viewed by 790 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Second Messenger Systems in Cellular Communication and Disease
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 623 | Submission Open
Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets
(This special issue belongs to the Section Molecular Biology)
Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials
edited by Caterina Ricci and
submission deadline 30 Jun 2026 | Viewed by 392 | Submission Open
Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization
Bacterial Molecular Biology: Stress Responses and Adaptation
edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa
submission deadline 30 Jun 2026 | Viewed by 362 | Submission Open
Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks
(This special issue belongs to the Section Molecular Biology)
Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation
edited by Konstantinos Venetis, and Marianna D'Ercole
submission deadline 30 Jun 2026 | Viewed by 345 | Submission Open
Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Interactions and Microbial Biocontrol Strategies in Host-Parasite-Pest Systems
edited by Rubén Marino Cardozo
submission deadline 30 Jun 2026 | Viewed by 224 | Submission Open
Keywords: molecular interactions; bioactive molecules; pest– microbe– host systems; microbial biocontrol; eco-evolutionary mechanisms; molecular parasitology; host– parasite interactions
(This special issue belongs to the Section Cellular Biochemistry)
Nanomaterials and Their Applications in Biomedicine—2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 214 | Submission Open
Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration
(This special issue belongs to the Section Bio-Engineered Materials)
Novel Insights into Epithelial Mesenchymal Transition (EMT) in Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 211 | Submission Open
Keywords: EMT; epithelial– mesenchymal plasticity; hybrid E/M states; single-cell; spatial transcriptomics/proteomics; multiplex IHC/IF; RNA in situ; CTCs; ctDNA; radiomics; computational pathology; immune evasion; therapy resistance; metastasis; biomarkers; reporting standards; reproducibility; clinical translation
(This special issue belongs to the Section Molecular Medicine)
Novel Biomarkers and Signaling Pathways in Kidney Diseases
edited by
submission deadline 30 Jun 2026 | Viewed by 190 | Submission Open
Keywords: kidney disease; signaling pathway; biomarkers; therapeutic strategies; molecular mechanisms
(This special issue belongs to the Section Molecular Biomarkers)
Non-Coding RNAs in Human Diseases: From Mechanisms to Therapeutic Opportunities
edited by Lei Jin
submission deadline 30 Jun 2026 | Viewed by 149 | Submission Open
Keywords: non-coding RNAs; human diseases; diagnostic markers; therapeutic targets; prognostic indicators
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Biology of Neurodevelopment
edited by
submission deadline 15 Jul 2026 | 5 articles | Viewed by 12334 | Submission Open
Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Biology)
The Role of Calcium Signaling in Cardiac and Skeletal Muscle submission deadline 15 Jul 2026 | 4 articles | Viewed by 10483 | Submission Open
Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation
(This special issue belongs to the Section Molecular Biology)
Advances in Computational Biology of Intrinsically Disordered Proteins
edited by
submission deadline 15 Jul 2026 | 1 articles | Viewed by 3236 | Submission Open
Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation
(This special issue belongs to the Section Bioinformatics and Systems Biology)
The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer
edited by
submission deadline 15 Jul 2026 | Viewed by 294 | Submission Open
Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy
(This special issue belongs to the Section Molecular Genetics)
Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration
edited by
submission deadline 15 Jul 2026 | Viewed by 196 | Submission Open
Keywords: biomaterials; molecular regulation; skeletal regeneration; cartilage regeneration; cell– matrix interaction; osteogenesis and chondrogenesis; mechanotransduction; immunomodulation; translational regenerative medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Mechanisms of RNA Regulation in Inflammation
edited by
submission deadline 17 Jul 2026 | 1 articles | Viewed by 2068 | Submission Open
Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Genetics)
Regulation of Synapses in the Brain
edited by and Guohao Wang
submission deadline 17 Jul 2026 | 1 articles | Viewed by 1782 | Submission Open
Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Protein Acetylation and Methylation—from Gene Regulation to Epigenetics, Metabolism, and Beyond
edited by
submission deadline 17 Jul 2026 | Viewed by 268 | Submission Open
Keywords: protein acetylation; protein methylation; histone modification; epigenetics; gene regulation; chromatin remodeling; metabolism; signal transduction; post-translational modification (PTM); proteomics; cancer biology; systems biology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors
edited by and Jason M. Conley
submission deadline 20 Jul 2026 | 5 articles | Viewed by 15935 | Submission Open
Keywords: diabetes; obesity; metabolism; GPCR; signaling
(This special issue belongs to the Section Molecular Biology)
Skeletal Muscle in Health, Exercise and Aging
edited by Barbara Munz
submission deadline 20 Jul 2026 | 3 articles | Viewed by 12237 | Submission Open
Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia
(This special issue belongs to the Section Molecular Biology)
Barrier Formation and Homeostasis in the Vertebrate Brain submission deadline 20 Jul 2026 | 3 articles | Viewed by 10240 | Submission Open
Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia
(This special issue belongs to the Section Cellular Biochemistry)
Recent Advances in Cellular and Non-Cellular Treatment of Stroke
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 6506 | Submission Open
Keywords: stroke; treatment; therapy; biomolecules; stem cells
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Chromatin and Chromosome Molecular Research
edited by Xin Bi
submission deadline 20 Jul 2026 | 3 articles | Viewed by 5625 | Submission Open
Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Wound Repair and Regeneration: From Molecular and Cellular Mechanisms to New Approaches
edited by Elia Ranzato
submission deadline 20 Jul 2026 | 3 articles | Viewed by 2864 | Submission Open
Keywords: wound repair; tissue regeneration; molecular mechanisms; cellular mechanisms; chronic wounds; fibrosis/scarring; biomaterials; stem cells; translational therapies
(This special issue belongs to the Section Molecular Medicine)
Advances in Type 2 Diabetes: Molecular Mechanisms and Therapeutic Innovations
edited by Orien L. Tulp
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1454 | Submission Open
Keywords: type 2 diabetes (T2DM); insulin resistance; GLUT4; sirtuins; epigenetic expression; nutrition; pharmacotherapeutics
(This special issue belongs to the Section Molecular Medicine)
Protein Structure Prediction in Drug Discovery, 3rd Edition submission deadline 20 Jul 2026 | Viewed by 315 | Submission Open
Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold
(This special issue belongs to the Section Bioinformatics and Systems Biology)
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