Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Intercellular Communication in Differentiation
edited by
submission deadline 25 Jun 2026 | Viewed by 163 | Submission Open
Keywords: intercellular communication; cellular differentiation; transcription factors; signaling hormone molecules
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 26 Jun 2026 | 6 articles | Viewed by 5128 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 26 Jun 2026 | 2 articles | Viewed by 1884 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases
edited by , and Arun Raja
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1041 | Submission Open
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology
(This special issue belongs to the Section Chemical Biology)
Spotlight on Hot Cancer Biological Biomarkers submission deadline 30 Jun 2026 | 4 articles | Viewed by 13123 | Submission Open
Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology
(This special issue belongs to the Section Molecular Biomarkers)
Mechanisms of Kidney Injury and Treatment Modalities
edited by Utpal Sen
submission deadline 30 Jun 2026 | 3 articles | Viewed by 11348 | Submission Open
Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration
(This special issue belongs to the Section Molecular Biology)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 30 Jun 2026 | 4 articles | Viewed by 11104 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease
edited by
submission deadline 30 Jun 2026 | 6 articles | Viewed by 9586 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
Polyphosphate (PolyP) in Health and Disease
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 6109 | Submission Open
Keywords: polyphosphate; polyP; biomarker and therapeutic target
(This special issue belongs to the Section Natural and Bio-derived Molecules)
New Insights into Protein Aggregation in Condensed and Amyloid States submission deadline 30 Jun 2026 | 3 articles | Viewed by 5968 | Submission Open
Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 30 Jun 2026 | 4 articles | Viewed by 5877 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Jun 2026 | 5 articles | Viewed by 5319 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 30 Jun 2026 | 2 articles | Viewed by 4788 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
New Insights into Stem Cell-Derived Exosomes in Human Health and Disease
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 4008 | Submission Open
Keywords: stem cells; exosomes; regenerative medicine; diagnostics
(This special issue belongs to the Section Cellular Biochemistry)
Lipid Signaling in Human Disease
edited by and Felicity Ashcroft
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3706 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3656 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
(This special issue belongs to the Section Biological Factors)
Mitochondria as a Target for Tissue Repair and Regeneration
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3605 | Submission Open
Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy
(This special issue belongs to the Section Molecular Biology)
Molecular Basis and Novel Treatment of Epilepsy
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3460 | Submission Open
Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research
(This special issue belongs to the Section Molecular Biology)
Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application submission deadline 30 Jun 2026 | 2 articles | Viewed by 3165 | Submission Open
Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders
(This special issue belongs to the Section Biological Factors)
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2623 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications submission deadline 30 Jun 2026 | 1 articles | Viewed by 2561 | Submission Open
Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine
(This special issue belongs to the Section Cellular Biochemistry)
Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies
edited by and Pragnya Rao Donthineni
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2390 | Submission Open
Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis
(This special issue belongs to the Section Cellular Biochemistry)
Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function submission deadline 30 Jun 2026 | 2 articles | Viewed by 2347 | Submission Open
Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology
(This special issue belongs to the Section Cellular Biochemistry)
Exercise Immunology: Molecular Mechanisms and Health Applications
edited by , , Michał Sławiński and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2180 | Submission Open
Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors
(This special issue belongs to the Section Molecular Biology)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2171 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Immune Response to Allergens submission deadline 30 Jun 2026 | 1 articles | Viewed by 1936 | Submission Open
Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System submission deadline 30 Jun 2026 | 1 articles | Viewed by 1482 | Submission Open
Keywords: mesenchymal stem/stromal cells; extracellular vesicles  ; musculoskeletal regeneration  ; immunomodulation  ; anabolism  ; cell therapy  ; cell-free therapy  ; secretome
Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine
edited by Xiao Fan and Youngil Lee
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1248 | Submission Open
Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy
(This special issue belongs to the Section Molecular Genetics)
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Jun 2026 | Viewed by 365 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials
edited by Caterina Ricci and
submission deadline 30 Jun 2026 | Viewed by 363 | Submission Open
Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization
Bacterial Molecular Biology: Stress Responses and Adaptation
edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa
submission deadline 30 Jun 2026 | Viewed by 330 | Submission Open
Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks
(This special issue belongs to the Section Molecular Biology)
Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation
edited by Konstantinos Venetis, and Marianna D'Ercole
submission deadline 30 Jun 2026 | Viewed by 306 | Submission Open
Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology
(This special issue belongs to the Section Molecular Biomarkers)
Second Messenger Systems in Cellular Communication and Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 297 | Submission Open
Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 288 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease
Molecular and Physiological Regulation of Biomechanical Signalling
edited by
submission deadline 30 Jun 2026 | Viewed by 281 | Submission Open
Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1& 2; microfluidics
Plant Secondary Metabolism Engineering and Bioactive Compounds submission deadline 30 Jun 2026 | Viewed by 276 | Submission Open
Keywords: bioactive compounds; elicitation; plant metabolism; fenetic transformation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Advances in Protein–Ligand Interactions: From Structure, Function to Applications, 2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 268 | Submission Open
Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes
(This special issue belongs to the Section Chemical Biology)
Adipose-Derived Stem Cells: 3D Culture Systems and Biological Insights
edited by Anna Barbara Di Stefano
submission deadline 30 Jun 2026 | Viewed by 246 | Submission Open
Keywords: stem cell biology; cancer stem cells; mesenchymal stem cells; induced pluripotent stem cells; 3D cultures; cell-based therapies
(This special issue belongs to the Section Cellular Biochemistry)
Enolase: Molecular Functions and Pathological Roles in Health and Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 231 | Submission Open
Keywords: enolase; enzyme regulation; cancer metabolism; neurodegeneration; autoimmune disease; biomarkers; inflammation; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Interactions and Microbial Biocontrol Strategies in Host-Parasite-Pest Systems
edited by Rubén Marino Cardozo
submission deadline 30 Jun 2026 | Viewed by 206 | Submission Open
Keywords: molecular interactions; bioactive molecules; pest– microbe– host systems; microbial biocontrol; eco-evolutionary mechanisms; molecular parasitology; host– parasite interactions
(This special issue belongs to the Section Cellular Biochemistry)
Nanomaterials and Their Applications in Biomedicine—2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 201 | Submission Open
Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration
(This special issue belongs to the Section Bio-Engineered Materials)
Novel Insights into Epithelial Mesenchymal Transition (EMT) in Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 191 | Submission Open
Keywords: EMT; epithelial– mesenchymal plasticity; hybrid E/M states; single-cell; spatial transcriptomics/proteomics; multiplex IHC/IF; RNA in situ; CTCs; ctDNA; radiomics; computational pathology; immune evasion; therapy resistance; metastasis; biomarkers; reporting standards; reproducibility; clinical translation
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanism of Viral Infection and Host Immunity in Transplantation
edited by Eva Mischak Weissinger
submission deadline 30 Jun 2026 | Viewed by 182 | Submission Open
Keywords: allogeneic stem cell/or solid organ transplantation; immunosuppressed host; immune reconstitution; virus reactive/specific cytotoxic T-/NK-cells; immune reconstitution post-transplantation
(This special issue belongs to the Section Molecular Medicine)
Novel Biomarkers and Signaling Pathways in Kidney Diseases
edited by
submission deadline 30 Jun 2026 | Viewed by 173 | Submission Open
Keywords: kidney disease; signaling pathway; biomarkers; therapeutic strategies; molecular mechanisms
(This special issue belongs to the Section Molecular Biomarkers)
Non-Coding RNAs in Human Diseases: From Mechanisms to Therapeutic Opportunities
edited by Lei Jin
submission deadline 30 Jun 2026 | Viewed by 134 | Submission Open
Keywords: non-coding RNAs; human diseases; diagnostic markers; therapeutic targets; prognostic indicators
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Biology of Neurodevelopment
edited by
submission deadline 15 Jul 2026 | 5 articles | Viewed by 11783 | Submission Open
Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Biology)
The Role of Calcium Signaling in Cardiac and Skeletal Muscle submission deadline 15 Jul 2026 | 4 articles | Viewed by 10103 | Submission Open
Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation
(This special issue belongs to the Section Molecular Biology)
Advances in Computational Biology of Intrinsically Disordered Proteins
edited by
submission deadline 15 Jul 2026 | 1 articles | Viewed by 3122 | Submission Open
Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation
(This special issue belongs to the Section Bioinformatics and Systems Biology)
The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer
edited by
submission deadline 15 Jul 2026 | Viewed by 276 | Submission Open
Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy
(This special issue belongs to the Section Molecular Genetics)
Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration
edited by
submission deadline 15 Jul 2026 | Viewed by 182 | Submission Open
Keywords: biomaterials; molecular regulation; skeletal regeneration; cartilage regeneration; cell– matrix interaction; osteogenesis and chondrogenesis; mechanotransduction; immunomodulation; translational regenerative medicine
(This special issue belongs to the Section Bio-Engineered Materials)
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