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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Microenvironment, Immunology and Precision Medicine of Liver Cancer

edited by Lynn Jeanette Savic

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5402 | Submission Open

Keywords: hepatocellular carcinoma; hypoxia; tumor microenvironment; immunometabolic crosstalk; tumor-associated macrophages

(This special issue belongs to the Section Biological Factors)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3794 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3749 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3548 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 31 Aug 2026 | 4 articles | Viewed by 3301 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3066 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Iron Metabolism in Cells

edited by

Magdalena Gryzik

and

Michela Asperti

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2997 | Submission Open

Keywords: iron metabolism; iron-related proteins; iron uptake; iron storage; mitochondrial iron metabolism; iron sensing mechanism; ferroptosis

(This special issue belongs to the Section Cellular Biochemistry)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2955 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Extracellular Non-Coding RNAs in Health and Disease

edited by

Arijit Mukhopadhyay

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2601 | Submission Open

Keywords: extracellular vesicles; exosomes; non-coding RNA; microRNA; biomarker

(This special issue belongs to the Section Molecular Biomarkers)

Regulation of Sperm Function and Embryo Development

edited by

Jacob Thundathil

and

John P. Kastelic

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2160 | Submission Open

Keywords: sperm; oocyte; embryo; genes; reproductive technologies

(This special issue belongs to the Section Molecular Reproduction)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1930 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

Photosynthetic Adaptation and Photoprotection in Plants

edited by

Roland Valcke

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1598 | Submission Open

Keywords: pigment– protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1392 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Mechanistic Insights of Retinal Diseases and Directions for New Therapeutics

edited by

Jing Chen

and Neetu Kushwah

submission deadline 31 Aug 2026 | 1 articles | Viewed by 933 | Submission Open

Keywords: retinopathy; AMD; retinal degeneration; ocular pharmacology; translational therapeutics

(This special issue belongs to the Section Molecular Medicine)

Molecular Genetics of Parasitic Protozoa

edited by

Paştiu Anamaria Ioana

submission deadline 31 Aug 2026 | 1 articles | Viewed by 902 | Submission Open

Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health

(This special issue belongs to the Section Molecular Genetics)

Molecular Pathogenesis of Cancer Induced by Inflammatory Bowel Disease

edited by Guang-Yu Yang and Senthil Radhakrishnan

submission deadline 31 Aug 2026 | 1 articles | Viewed by 842 | Submission Open

Keywords: cancer; inflammatory bowel disease; genomic; pathogenesis; biomarkers; pathway; therapeutic strategies

(This special issue belongs to the Section Biological Factors)

Application of Bioinformatics in Medicine, 2nd Edition

edited by

Le Zhang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 608 | Submission Open

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Biomarkers of Oxidative and Nitrosative Stress: Mechanisms, Detection, and Clinical Significance

edited by

Narcyz Knap

and

Michał Woźniak

submission deadline 31 Aug 2026 | 1 articles | Viewed by 597 | Submission Open

Keywords: oxidative stress; nitrosative stress; reactive oxygen species (ROS); reactive nitrogen species (RNS); lipid peroxidation; ferroptosis; protein oxidation; DNA oxidative modifications; antioxidant defense mechanisms; free radicals; redox signaling; redox biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Aug 2026 | Viewed by 418 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

Recent Advances in Immunotherapy for Mesothelioma

edited by Licun Wu

submission deadline 31 Aug 2026 | Viewed by 286 | Submission Open

Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity

(This special issue belongs to the Section Molecular Medicine)

State of the Art of Myology: 3rd Edition

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2026 | Viewed by 253 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Nanomaterials and Iron Proteins: Molecular Interactions, Structural Characterization and Biomedical Applications

edited by

Georgia C. Papaefthymiou

submission deadline 31 Aug 2026 | Viewed by 249 | Submission Open

Keywords: iron storage (ferritin); iron transport (transferrin; ferroportin); O2 storage (myoglobin); O2 transport (hemoglobin); electron transfer (Fe-S proteins; cytochromes); ferritin degradation; (ferritinophagy); oxidative stress protection (ferritin; Dps proteins); biocompatible iron-oxide nanoparticles; magnetoferritin; biogenic magnetite by magnetotactic bacteria (magnetosomes); iron-based metal– organic frameworks (Fe-MOFs)

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Antimicrobial Activity and Resistance in Pathogens

edited by

Lia Mara Diţu

submission deadline 31 Aug 2026 | Viewed by 246 | Submission Open

Keywords: MDR profile in fungi; anti-fungal strategies; drug– target interactions; nanotechnology in antimicrobials; quorum-sensing molecular interactions; biofilm

(This special issue belongs to the Section Molecular Biology)

Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Harrys Kishore Charles Jacob

and

John Lalith Charles Richard

submission deadline 31 Aug 2026 | Viewed by 240 | Submission Open

Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics

Glycans in Health and Disease: Molecular Insights and Clinical Implications

edited by

Vaibhav Tiwari

submission deadline 31 Aug 2026 | Viewed by 235 | Submission Open

Keywords: glycans; glycobiology; proteoglycans; heparan sulfate; infection; pathogen host cell interaction; disease; cancer; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Physiological Responses and Biomolecular Adaptations to Environmental and Biotic Stress in Aquatic Species

edited by

Eleni Golomazou

submission deadline 31 Aug 2026 | Viewed by 232 | Submission Open

Keywords: aquaculture; fish pathogens; fish welfare; health protection

(This special issue belongs to the Section Molecular Biology)

From Molecular Mechanisms to Therapeutics: Multidisciplinary Advances in Gene Expression Research

edited by Cristina Maracci

submission deadline 31 Aug 2026 | Viewed by 203 | Submission Open

Keywords: gene regulation; drug design; computational biology; AI modeling; protein synthesis; gene regulatory network; transcription; post-transcriptional regulation; molecular biology

(This special issue belongs to the Section Molecular Genetics)

Nutrition, Metabolism, and Obesity: Novel Strategies and Molecular Mechanisms—Future Perspectives, 2nd Edition

edited by Marion Korach-André

submission deadline 31 Aug 2026 | Viewed by 200 | Submission Open

Keywords: diet; nutrients; obesity; inflammation; fat; glucose intolerance; insulin resistance; fatty liver disease; metabolic syndrome

(This special issue belongs to the Section Molecular Medicine)

Dynamic Interactions Between Biomolecules: Insights from Bioinformatics and Computational Biology

edited by Jayadev Joshi

submission deadline 31 Aug 2026 | Viewed by 192 | Submission Open

Keywords: biomolecular interactions; molecular dynamics; structural bioinformatics; computational biology; protein interactions; conformational dynamics; machine learning; systems biology; integrative modeling; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Imaging Biomarkers in Inflammation and Metabolic Disorders

edited by

Uwe Himmelreich

submission deadline 31 Aug 2026 | Viewed by 169 | Submission Open

Keywords: inflammation; metabolic disorders; molecular imaging; metabolism; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms and Therapeutic Strategies in Pediatric Immune Dysregulation

edited by Rita Consolini and

Giorgio Costagliola

submission deadline 31 Aug 2026 | Viewed by 154 | Submission Open

Keywords: immune dysregulation; autoimmunity; inborn errors of immunity; targeted therapies; immunomodulatory treatments; genetics; gene therapy; hematopoietic stem cell transplantation

(This special issue belongs to the Section Molecular Medicine)

Next-Gen Antimicrobials: Discovery, Engineering and Synergistic Approaches

edited by

Juan Borrero

submission deadline 31 Aug 2026 | Viewed by 138 | Submission Open

Keywords: antimicrobial agents; antimicrobial discovery; antimicrobial engineering; antimicrobial applications; synergistic antimicrobial strategies

(This special issue belongs to the Section Molecular Medicine)

The Fibroblast-IL-6 Axis in Skin Cancer Microenvironment

edited by

Lukas Lacina

and

Karel Smetana, Jr.

submission deadline 31 Aug 2026 | Viewed by 138 | Submission Open

Keywords: cancer microenvironment; cancer-associated fibroblasts (CAFs); cancer supporting inflammation; malignant melanoma; non-Melanoma Skin Cancer (NMSC); IL-6 signalling pathway; IL-6 receptor; ageing; senescence associated secretory phenotype (SASP)

(This special issue belongs to the Section Cellular Biochemistry)

Copper Signaling and Redox Biology in Vascular Function and Disease

edited by Archita Das

submission deadline 31 Aug 2026 | Viewed by 122 | Submission Open

Keywords: redox signaling; endothelial cell; vascular biology; angiogenesis; atherosclerosis; diabetes; copper transporter proteins

(This special issue belongs to the Section Molecular Medicine)

The Heme Oxygenase/Biliverdin Reductase System in Human Health and Disease: New Molecular Insights and Therapeutic Targets

edited by Cesare Mancuso

submission deadline 1 Sep 2026 | 4 articles | Viewed by 3885 | Submission Open

Keywords: Alzheimer’ s disease; bilirubin; cancer; carbon monoxide; cardiovascular diseases; cerebral malaria; diabetes mellitus; drug research and development; inflammation; Parkinson’ s disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition

edited by

Juei-Tang Cheng

submission deadline 1 Sep 2026 | 1 articles | Viewed by 2525 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

Molecular Mechanisms and Microenvironmental Regulation in Bone-Related Diseases and Muscle Atrophy

edited by Haitao Wang

submission deadline 1 Sep 2026 | 2 articles | Viewed by 2276 | Submission Open

Keywords: bone diseases; muscle atrophy; osteoporosis; osteoarthritis; osteosarcoma; sarcopenia; heterotopic ossification; molecular mechanisms; microenvironment; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 1 Sep 2026 | 2 articles | Viewed by 1772 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood– brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

Digital Twins in Biomedical and Pharmaceutical Research

edited by Shuxing Zhang and Yinan Sun

submission deadline 1 Sep 2026 | Viewed by 134 | Submission Open

Keywords: digital twins; artificial intelligence (AI); big data; drug discovery and development; clinical trials; personalized medicine

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 15 Sep 2026 | 3 articles | Viewed by 5773 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Sep 2026 | 2 articles | Viewed by 1056 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies

edited by Takashi Onodera and

Akikazu Sakudo

submission deadline 15 Sep 2026 | Viewed by 622 | Submission Open

Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)

Microbial Extracellular Vesicles: From Virulence Factors to Therapeutic Targets

edited by

Daria Nicolosi

submission deadline 15 Sep 2026 | Viewed by 145 | Submission Open

Keywords: microbial extracellular vesicles; virulence factors; host– pathogen interaction; drug delivery; biomarkers

Epigenetic and Pharmacological Insights into Cognitive Dysfunction Driven by Genetic and Environmental Factors

edited by

Pei Li

submission deadline 15 Sep 2026 | Viewed by 138 | Submission Open

Keywords: cognitive dysfunction; epigenetic regulation; genetic risk; environmental exposure

(This special issue belongs to the Section Molecular Genetics)

Extracellular Non-Coding RNAs as Key Regulators and Biomarkers in Reproductive Processes

edited by Rosalia Battaglia

submission deadline 15 Sep 2026 | Viewed by 126 | Submission Open

Keywords: extracellular non-coding RNAs; reproductive biology; extracellular vesicles; biomarkers; assisted reproductive technology

(This special issue belongs to the Section Molecular Reproduction)

Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides

edited by

Dariusz Stępkowski

submission deadline 16 Sep 2026 | 2 articles | Viewed by 4203 | Submission Open

Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors

Novel Diagnostic Tools and Biomarkers in Hematology

edited by Lars Kaestner

submission deadline 17 Sep 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: blood-based biomarkers; diagnostic innovation; omics technologies; microfluidics; photonics; machine learning; hematology; precision medicine

(This special issue belongs to the Section Molecular Biomarkers)

Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism

edited by

Amit Sinha

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics

Biotherapeutic Analysis: Precision Characterization and Quality Control

edited by

Jared Auclair

submission deadline 20 Sep 2026 | 2 articles | Viewed by 970 | Submission Open

Keywords: biotherapeutics; analytical characterization; quality control; mass spectrometry; cell therapy; gene therapy; biologics; process analytical technology; regulatory science

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 20 Sep 2026 | Viewed by 228 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

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