Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 1 September 2024 | Viewed by 424202
Special Issue Editors
Interests: hepatitis C, B, HIV, and other viral hepatitis; alcohol-associated liver disease; innate immunity; antigen presentation; proteasome; protein posttranslational modifications; animal models for a hepatitis study; long-acting drugs
Special Issues, Collections and Topics in MDPI journals
Interests: alcohol-associated liver disease and metabolic dysfunction-associated liver disease: pathogenesis and treatment modality; methylation defects
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alcohol consumption causes damage to various organs and systems. Liver is a primary target for the detrimental effects of alcohol since this substance of abuse is mainly metabolized by liver cells which express high levels of two major alcohol oxiding enzymes, alcohol dehydrogenase and CYP2E1. However, other organs, including brain, gut, pancreas, lungs, immune system are also affected by alcohol. Alcohol may also serve as a second hit for progression of viral infections, autoimmune diseases and cancer. Common mechanisms of alcohol-related organ injury include increases in oxidative stress, methylation impairments, posttranslational modifications of proteins, dysregulation of lipid metabolism and signal transduction pathways that ultimately affect cell survival and function. This Topical Collection will cover the pathobiology of alcohol-sensitive organ injury and the development of targeted treatment strategies.
We encourage you to share your data and thoughts in this broad field that clearly demonstrates how the harmful effects of alcohol contribute to disease initiation and progression in the liver, brain, gut, heart, lungs, and other organs and tissues of the body.
Prof. Dr. Natalia Osna
Prof. Dr. Kusum Kharbanda
Collection Editors
Manuscript Submission Information
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Keywords
- alcoholic liver disease (ALD)
- steatohepatitis
- fibrosis
- cirhosis
- parenhymal and non-parenhymal liver cells
- brain
- gut
- lungs
- immune responses
- oxidative stress
- methylation
- viral infections
- post-translational protein modifications
- treatment of ALD