Advances in Nanozyme-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 949

Special Issue Editors


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Guest Editor
School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Interests: food safety analysis; nanozymes; environmental analysis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
Interests: nanozymes; environmental detection; food analysis; biochemical sensing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanozymes have great potential to be used as an alternative to natural enzymes in a variety of fields. The emerging applications of biosensors include analytical, environmental, and biomedical applications. Compared with natural enzymes, nanozymes have the merits of low cost, high stability, and large-scale production. Since the pioneering work by Yan and co-workers in 2007, nanozymes with diverse enzyme-like activities have been identified and are widely used in biosensing, biomedicine, and biotherapy.

For this Special Issue, we welcome original research papers as well as reviews of current developments in the design of nanozyme-based biosensors. This includes the design of state-of-the-art nanozyme-based biosensors for analytical, environmental, and biomedical applications. Theoretical research on nanozymes with high specific activity is also encouraged. The design and development of the catalytic mechanism of nanozymes, rational engineering of active sites, and portable/handheld nanozyme-based platforms for point-of-care applications are of particular interest. Reviews should provide an in-depth examination of the most recent research in a specific context or discuss existing and future issues related to the nanozyme field.

Dr. Jiaojiao Zhou
Dr. Xiangheng Niu
Guest Editors

Manuscript Submission Information

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Keywords

  • nanozymes
  • biosensor
  • bioimaging
  • nanozyme-based aptasensor
  • nanozyme-involved immunoassay
  • food analysis
  • environmental detection
  • nanozyme-based biochemical analysis

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Published Papers (1 paper)

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Review

35 pages, 5385 KiB  
Review
Exploring Nucleic Acid Nanozymes: A New Frontier in Biosensor Development
by Keren Chen, Zaihui Du, Yangzi Zhang, Ruobin Bai, Longjiao Zhu and Wentao Xu
Biosensors 2025, 15(3), 142; https://doi.org/10.3390/bios15030142 - 24 Feb 2025
Viewed by 667
Abstract
With the growing interest in nucleic acids and nanozymes, nucleic acid nanozymes (NANs) have emerged as a promising alternative to traditional enzyme catalysts, combining the advantages of nucleic acids and nanomaterials, and are widely applied in the field of biosensing. This review provides [...] Read more.
With the growing interest in nucleic acids and nanozymes, nucleic acid nanozymes (NANs) have emerged as a promising alternative to traditional enzyme catalysts, combining the advantages of nucleic acids and nanomaterials, and are widely applied in the field of biosensing. This review provides a comprehensive overview of recent studies on NAN-based biosensors. It classifies NANs based on six distinct enzymatic activities: peroxidase-like, oxidase-like, catalase-like, superoxide dismutase-like, laccase-like, and glucose oxidase-like. This review emphasizes how the catalytic activity of nanozymes is significantly influenced by the properties of nucleic acids and explores the regulatory mechanisms governing the catalytic activity of NANs. Additionally, it systematically reviews important research progress on NANs in colorimetric, fluorescent, electrochemical, SERS, and chemiluminescent sensors, offering insights into the development of the NAN field and biosensor applications. Full article
(This article belongs to the Special Issue Advances in Nanozyme-Based Biosensors)
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