Design, Fabrication, and Applications of Microfluidic Devices for Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 3940

Special Issue Editors


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Guest Editor
Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, China
Interests: lab on a chip; microfluidic chips

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Guest Editor
Division of Advanced Manufacturing, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Interests: microfluidic chips; flexible sensors and acuators

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue is the design, fabrication, and applications of microfluidic devices for biosensing, and we aim to gather original articles and reviews showing research advances, fabrication, innovative applications, new challenges, and future perspectives in microfluidic devices for biosensing in biology, medicine, health, environmental monitoring, and more.

Microfluidic technology enables the automated pretreatment of samples, as well as the transportation of nanoliters or picoliters of solutions to designated biosensing sites. This facilitates high-throughput and automated detection in biosensors. Furthermore, the characteristics of microfluidics, such as the large specific surface area, can enhance the sensitivity of biosensors. Consequently, numerous biosensors incorporating microfluidic structures have been developed.

The objective of this Special Issue is to provide readers with an understanding of the potential of microfluidic technology in the development of biosensors, as well as an overview of the current challenges and opportunities in meeting application needs. The authors may include the fabrication processes for microfluidic devices. Indeed, the most conventional methods, e.g., PDMS on glass or SiO2, though successful in a laboratory setting, are not applicable on an industrial basis, which makes them very limited. Thus, reviews of alternative processes would be very interesting for readers.

Submissions may include, but are not limited to, the following topics:

  • sample-in–result-out  bioassay devices/point-of-care devices/diagnostic devices/healthcare medical devices;
  • devices for high-throughput, low-cost, and robust bioassays;
  • organ-on-a-chip models;
  • macro–micro interfaces for multiscale fluid handling, integration into experimental workflows, and coupling to analytical instruments;
  • reviews of fabrication processes that are more suitable for industrial production than conventional methods, e.g., PDMS on glass or SiO2;
  • microfluidic biosensing principles and devices for increased sensitivity.

Dr. Lei Wu
Dr. Xiang Qian
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • microfluidic
  • biosensors
  • high-throughput
  • automation

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Published Papers (1 paper)

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Research

14 pages, 5172 KiB  
Article
Fabrication of Patterned Magnetic Particles in Microchannels and Their Application in Micromixers
by Tianhao Li, Chen Yang, Zihao Shao, Ya Chen, Jiahui Zheng, Jun Yang and Ning Hu
Biosensors 2024, 14(9), 408; https://doi.org/10.3390/bios14090408 - 23 Aug 2024
Viewed by 924
Abstract
Due to the extremely low Reynolds number, the mixing of substances in laminar flow within microfluidic channels primarily relies on slow intermolecular diffusion, whereas various rapid reaction and detection requirements in lab-on-a-chip applications often necessitate the efficient mixing of fluids within short distances. [...] Read more.
Due to the extremely low Reynolds number, the mixing of substances in laminar flow within microfluidic channels primarily relies on slow intermolecular diffusion, whereas various rapid reaction and detection requirements in lab-on-a-chip applications often necessitate the efficient mixing of fluids within short distances. This paper presents a magnetic pillar-shaped particle fabrication device capable of producing particles with planar shapes, which are then utilized to achieve the rapid mixing of multiple fluids within microchannels. During the particle fabrication process, a degassed PDMS chip provides self-priming capabilities, drawing in a UV-curable adhesive-containing magnetic powder and distributing it into distinct microwell structures. Subsequently, an external magnetic field is applied, and the chip is exposed to UV light, enabling the mass production of particles with specific magnetic properties through photo-curing. Without the need for external pumping, this chip-based device can fabricate hundreds of magnetic particles in less than 10 min. In contrast to most particle fabrication methods, the degassed PDMS approach enables self-priming and precise dispensing, allowing for precise control over particle shape and size. The fabricated dual-layer magnetic particles, featuring fan-shaped blades and disk-like structures, are placed within micromixing channels. By manipulating the magnetic field, the particles are driven into motion, altering the flow patterns to achieve fluid mixing. Under conditions where the Reynolds number in the chip ranges from 0.1 to 0.9, the mixing index for substances in aqueous solutions exceeds 0.9. In addition, experimental analyses of mixing efficiency for fluids with different viscosities, including 25 wt% and 50 wt% glycerol, reveal mixing indices exceeding 0.85, demonstrating the broad applicability of micromixers based on the rapid rotation of magnetic particles. Full article
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