Nanomaterial-Based Biosensors for Biomedical Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1691

Special Issue Editors


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Guest Editor
Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, India
Interests: material characteristics; SEM analysis

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Guest Editor
School of Science, Harbin Institute of Technology, Shenzhen 518055, China
Interests: molecular imaging probes; nanomedicines; fluorescence imaging; piezoelectric materials; imaging-guided therapy; antibacterial therapy; anticancer theranostics; nanoparticles; NIR-II fluorescence
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Special Issue Information

Dear Colleagues,

The biomedical detection of disease biomarkers and biological molecules has undergone a revolution in the last few decades, driven by groundbreaking research in nanomaterial-based biosensors. These types of biosensors display enhanced selectivity and sensitivity and rapid responses in detecting a wide range of disease biomarkers and biological molecules, even at ultra-low concentrations, due to the augmented surface-to-volume ratio-based enhanced physicochemical properties of the nanomaterials used. Effective biorecognition events are made possible by nanoparticles, nanoclusters, nanowires, and quantum dots, which allow for multiplexed, dependable, and real-time detection in a variety of biological samples, including blood and tissue fluids. By enabling data-driven analysis and remote health monitoring, the integration of such nanomaterial-based biosensors with artificial intelligence and point-of-care systems improves diagnostic capabilities further. Therefore, nanomaterial-based biosensors have great potential to improve non-invasive biological monitoring, tailored medicine, and early diagnosis, all of which will have a significant influence on human healthcare.

While numerous reviews and studies have covered the individual aspects of nanomedicine, there remains a need for an integrative outlook that spans from nanomaterial design to clinical translation. This Special Issue distinguishes itself by combining cross-functional perspectives linking material innovation with diagnostic efficacy with precision, and thereby filling a critical gap in the existing literature and aligning with the latest developments in personalized and precision medicine.

Dr. Bing Guo
Dr. Dhananjoy Mondal
Dr. Shubham Roy
Guest Editors

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Keywords

  • nanomaterials
  • imaging
  • theranostics
  • imaging-guided therapy
  • diagnosis
  • materials engineering
  • molecular imaging
  • near-infrared fluorescence
  • MRI
  • biosensors

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Published Papers (1 paper)

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Review

34 pages, 4925 KB  
Review
Nanomaterial Engineered Biosensors and Stimulus–Responsive Platform for Emergency Monitoring and Intelligent Diagnosis
by Bo Fang, Yuanyuan Chen, Hui Jiang, Xiaohui Liu and Xuemei Wang
Biosensors 2025, 15(12), 789; https://doi.org/10.3390/bios15120789 - 1 Dec 2025
Cited by 2 | Viewed by 1431
Abstract
Biosensing technology serves as a cornerstone in biomedical diagnostics, environmental monitoring, personalized medicine, and wearable devices, playing an indispensable role in precise detection and real–time monitoring. Compared with traditional sensing platforms, functional nanomaterials—by virtue of their ultra–large specific surface area, exceptional optoelectronic properties, [...] Read more.
Biosensing technology serves as a cornerstone in biomedical diagnostics, environmental monitoring, personalized medicine, and wearable devices, playing an indispensable role in precise detection and real–time monitoring. Compared with traditional sensing platforms, functional nanomaterials—by virtue of their ultra–large specific surface area, exceptional optoelectronic properties, and superior catalytic activity—significantly enhance the sensitivity, selectivity, and response speed of biosensors. This has enabled ultrasensitive, rapid, and even in situ detection of disease biomarkers, pollutants, and pathogens. This review summarizes recent advances in five key categories of functional nanomaterials—metallic, semiconductor, carbon–based, two–dimensional, and stimulus–responsive materials—for advanced biosensing applications. It elucidates the structure–property relationships governing sensing performance, such as the surface plasmon resonance of gold nanoparticles and the high carrier mobility of graphene, and analyzes the core mechanisms behind optical sensing, electrochemical sensing, and emerging multimodal sensing strategies. With a focus on medical diagnostics, wearable health monitoring, and environmental and food safety surveillance, the review highlights the application value of functional nanomaterials across diverse scenarios. Current research is progressively moving beyond single–performance optimization toward intelligent design, multifunctional integration, and real–world deployment, though challenges related to industrial application remain. Finally, the review outlines existing issues in the development of functional nanomaterial–based biosensors and offers perspectives on the integration of nanomaterials with cutting–edge technologies and the construction of novel sensing systems. This work aims to provide insights for the rational design of functional nanomaterials and the cross–disciplinary translation of biosensing technologies. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors for Biomedical Detection)
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