Functional Nucleic Acids for Theranostic Application

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1943

Special Issue Editors


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Guest Editor
School of Life Sciences, Central South University, Changsha, China
Interests: DNAzyme; aptamer; molecular beacon; DNA nanotechnology; liquid biopsy; biosensor

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Guest Editor
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Interests: inflammation; cancer; biomarker

Special Issue Information

Dear Colleagues,

Functional nucleic acids such as aptamers, DNAzymes, RNAzymes and DNA nanostructures have been widely implanted in modern biomedicine. Compared to other functional materials, functional nuclei acids are cheaper, more accessible and more compatible in complex biological conditions. More importantly, the highly ordered chemical structure of functional nuclei acids make them more favored to be modified and engineered for various applications, including biosensing, imaging and therapy. Considering the continued popularity of functional nucleic acids in biomedical research, this Special Issue, ‘Functional nucleic acids for theranostic application’, aims to collect the most up-to-date research on the application of functional nucleic acids in health monitoring, pathogen determination, biomarker analysis/imaging, diseases treatment/management, and so on. Any form of submission—including articles or reviews—are welcomed.

With best regards,

Dr. Changbei Ma
Dr. Zhenwei Tang
Guest Editors

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Published Papers (1 paper)

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Review

17 pages, 3708 KiB  
Review
Functional Nucleic Acid Probes Based on Two-Photon for Biosensing
by Kefeng Wu, Changbei Ma and Yisen Wang
Biosensors 2023, 13(9), 836; https://doi.org/10.3390/bios13090836 - 23 Aug 2023
Cited by 2 | Viewed by 1604
Abstract
Functional nucleic acid (FNA) probes have been widely used in environmental monitoring, food analysis, clinical diagnosis, and biological imaging because of their easy synthesis, functional modification, flexible design, and stable properties. However, most FNA probes are designed based on one-photon (OP) in the [...] Read more.
Functional nucleic acid (FNA) probes have been widely used in environmental monitoring, food analysis, clinical diagnosis, and biological imaging because of their easy synthesis, functional modification, flexible design, and stable properties. However, most FNA probes are designed based on one-photon (OP) in the ultraviolet or visible regions, and the effectiveness of these OP-based FNA probes may be hindered by certain factors, such as their potential for photodamage and limited light tissue penetration. Two-photon (TP) is characterized by the nonlinear absorption of two relatively low-energy photons of near-infrared (NIR) light with the resulting emission of high-energy ultraviolet or visible light. TP-based FNA probes have excellent properties, including lower tissue self-absorption and autofluorescence, reduced photodamage and photobleaching, and higher spatial resolution, making them more advantageous than the conventional OP-based FNA probes in biomedical sensing. In this review, we summarize the recent advances of TP-excited and -activated FNA probes and detail their applications in biomolecular detection. In addition, we also share our views on the highlights and limitations of TP-based FNA probes. The ultimate goal is to provide design approaches for the development of high-performance TP-based FNA probes, thereby promoting their biological applications. Full article
(This article belongs to the Special Issue Functional Nucleic Acids for Theranostic Application)
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