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Biosensors
Special Issues
Advances in Materials and Chemistry for Wearable Biosensors and Bioelectronics
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Advances in Materials and Chemistry for Wearable Biosensors and Bioelectronics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Wearable Biosensors".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 9466

Special Issue Editors

Dr. Kunal Mondal

E-Mail Website
Guest Editor
1. Materials Science and Engineering Department, Idaho National Laboratory, Idaho Falls, ID 83415, USA
2. Affiliate Faculty & Allied Graduate Faculty, Department of Civil & Environmental Engineering, Idaho State University, Pocatello, ID 83209, USA
Interests: nano-food technology; food nutrition; food safety; biomaterials; biosensor
Special Issues, Collections and Topics in MDPI journals
Dr. Nagaraj Shetti

E-Mail Website
Guest Editor
School of Advanced Sciences, KLE Technological University, Hubballi 580031, Karnataka, India
Interests: sensors; biosensors; electroanalytical chemistry; electroanalysis

Special Issue Information

Dear Colleagues,

Increasing populations are challenging the healthcare system like never before, leading to various socioeconomic complications. Most medical appointments can cost huge amounts of time and money.  One way to ease these problems is to create portable biosensors and point-of-care devices that can perform tests quickly, which consume minimum time and expense. For this to be achieved, the development of wearable biosensors that can non-invasively accomplish medical assessments while the user can make themselves busy in their usual routine is necessary.

Wearable biosensors are capable of measuring physiological parameters, such as vital signs (i.e., heart rate, respiration rate, body and skin temperature, oxygen saturation, etc.), skin conductance, blood pressure, electrocardiogram (ECG), electroencephalography (EEG), acceleration, rotation, etc., and for countless monitoring purposes to advance patients’ quality of life, health management, disease control status, and even the survival rate of emergency rescue operations. However, developing such devices remains challenging. Wearable monitors that measure several biomarkers, such as glucose, cholesterol, breast cancer, etc., are an advanced technology that connects smart electronics to point-of-care detection of biomolecules. This special issue will specifically address recent research and developments in these wearable biosensors, which can significantly cut healthcare costs in worldwide communities, and whose continuous improvement can potentially change the future of worldwide healthcare.

This Special Issue aims to cover recent advances in the development of wearable biosensors and bioelectronics, related materials, and their characterizations, highlighting the advantages provided by the used material environment and describing future trends in their evolution toward outperforming diagnostics. Diverse ideas and approaches offering the integration of materials and characterization of transducer materials for the fabrication of biosensors used in highly sensitive as well as highly specific detection of biological analytes are also welcome in this Special Issue. 

Dr. Kunal Mondal
Dr. Nagaraj P. Shetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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16 pages, 9065 KiB  
Article
A Chemometric-Assisted Colorimetric-Based Inexpensive Paper Biosensor for Glucose Detection
by Vinay Kishnani, Shrishti Kumari and Ankur Gupta
Biosensors 2022, 12(11), 1008; https://doi.org/10.3390/bios12111008 - 11 Nov 2022
Cited by 6 | Viewed by 1704
Abstract
This article reports a simple and inexpensive leak-proof paper pad with an initial selection of a paper substrate on the grounds of surface morphology and fluid absorption time. Herein, a drying method is used for glucose detection on a paper pad through colorimetric [...] Read more.
This article reports a simple and inexpensive leak-proof paper pad with an initial selection of a paper substrate on the grounds of surface morphology and fluid absorption time. Herein, a drying method is used for glucose detection on a paper pad through colorimetric analysis, and the spot detection of glucose is analyzed by optimizing the HRP concentration and volume to obtain accurate results. The rapid colorimetric method for the detection of glucose on the paper pad was developed with a limit of detection (LOD) of 2.92 mmol L−1. Furthermore, the effects of the detection conditions were investigated and discussed comprehensively with the help of chemometric methods. Paper pads were developed for glucose detection with a range of 0.5–20 mM (apropos to the normal glucose level in the human body) and 0.1–0.5 M (to test the excessive intake of glucose). The developed concept has huge potential in the healthcare sector, and its extension could be envisioned to develop the reported paper pad as a point-of-care testing device for the initial screening of a variety of diseases. Full article
(This article belongs to the Special Issue Advances in Materials and Chemistry for Wearable Biosensors and Bioelectronics)
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11 pages, 3218 KiB  
Article
Quantifying Deformation and Migration Properties of U87 Glioma Cells Using Dielectrophoretic Forces
by Meltem Elitas, Monsur Islam, Jan G. Korvink, Esra Sengul, Pouya Sharbati, Beyzanur Ozogul and Sumeyra Vural Kaymaz
Biosensors 2022, 12(11), 946; https://doi.org/10.3390/bios12110946 - 31 Oct 2022
Cited by 2 | Viewed by 1565
Abstract
Glioblastoma multiforme is one of the most aggressive malignant primary brain tumors. To design effective treatment strategies, we need to better understand the behavior of glioma cells while maintaining their genetic and phenotypic stability. Here, we investigated the deformation and migration profile of [...] Read more.
Glioblastoma multiforme is one of the most aggressive malignant primary brain tumors. To design effective treatment strategies, we need to better understand the behavior of glioma cells while maintaining their genetic and phenotypic stability. Here, we investigated the deformation and migration profile of U87 Glioma cells under the influence of dielectrophoretic forces. We fabricated a gold microelectrode array within a microfluidic channel and applied sinusoidal wave AC potential at 3 Vpp, ranging from 30 kHz to 10 MHz frequencies, to generate DEP forces. We followed the dielectrophoretic movement and deformation changes of 100 glioma cells at each frequency. We observed that the mean dielectrophoretic displacements of glioma cells were significantly different at varying frequencies with the maximum and minimum traveling distances of 13.22 µm and 1.37 µm, respectively. The dielectrophoretic deformation indexes of U87 glioma cells altered between 0.027–0.040. It was 0.036 in the absence of dielectrophoretic forces. This approach presents a rapid, robust, and sensitive characterization method for quantifying membrane deformation of glioma cells to determine the state of the cells or efficacy of administrated drugs. Full article
(This article belongs to the Special Issue Advances in Materials and Chemistry for Wearable Biosensors and Bioelectronics)
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Review

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78 pages, 16259 KiB  
Review
Graphene and Its Derivatives: Synthesis and Application in the Electrochemical Detection of Analytes in Sweat
by Anoop Singh, Aamir Ahmed, Asha Sharma and Sandeep Arya
Biosensors 2022, 12(10), 910; https://doi.org/10.3390/bios12100910 - 21 Oct 2022
Cited by 20 | Viewed by 5710
Abstract
Wearable sensors and invasive devices have been studied extensively in recent years as the demand for real-time human healthcare applications and seamless human–machine interaction has risen exponentially. An explosion in sensor research throughout the globe has been ignited by the unique features such [...] Read more.
Wearable sensors and invasive devices have been studied extensively in recent years as the demand for real-time human healthcare applications and seamless human–machine interaction has risen exponentially. An explosion in sensor research throughout the globe has been ignited by the unique features such as thermal, electrical, and mechanical properties of graphene. This includes wearable sensors and implants, which can detect a wide range of data, including body temperature, pulse oxygenation, blood pressure, glucose, and the other analytes present in sweat. Graphene-based sensors for real-time human health monitoring are also being developed. This review is a comprehensive discussion about the properties of graphene, routes to its synthesis, derivatives of graphene, etc. Moreover, the basic features of a biosensor along with the chemistry of sweat are also discussed in detail. The review mainly focusses on the graphene and its derivative-based wearable sensors for the detection of analytes in sweat. Graphene-based sensors for health monitoring will be examined and explained in this study as an overview of the most current innovations in sensor designs, sensing processes, technological advancements, sensor system components, and potential hurdles. The future holds great opportunities for the development of efficient and advanced graphene-based sensors for the detection of analytes in sweat. Full article
(This article belongs to the Special Issue Advances in Materials and Chemistry for Wearable Biosensors and Bioelectronics)
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