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Microfluidics and Organ-on-a-Chip for Disease Modeling and Drug Screening (2nd...
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Microfluidics and Organ-on-a-Chip for Disease Modeling and Drug Screening (2nd Edition)

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 3663

Special Issue Editors

Dr. Rohollah Nasiri

E-Mail Website
Guest Editor
Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Interests: microfluidics; organ-on-a-chip; cancer research; biosensors; tissue engineering; microfabrication; medical devices
Special Issues, Collections and Topics in MDPI journals
Dr. Mohammadreza Nikmaneshi

E-Mail Website
Guest Editor
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Interests: microfluidics; organ-on-a-chip; biomedical engineering; systems biology; tumor microenvironment

Special Issue Information

Dear Colleagues,

Advanced in vitro cell culture systems, including microfluidic organ-on-a-chip (OoC) platforms, represent novel and promising technologies in biomedicine. These systems aim to mimic the features of human organs outside of the body. They are increasingly being employed to study the functionality of different organs for applications such as disease modeling, drug evolutions, and personalized medicine. In addition, these in vitro models can accelerate the development of drugs by eliminating or reducing animal testing.

This Special Issue aims to elucidate these promising and dynamic areas of research and gather original research articles and comprehensive reviews on the role of these in vitro models and platforms in order to further enhance the application of disease modeling and drug screening in preclinical studies.

The scope of this Special Issue includes, but is not limited to, the following topics:

  • Novel devices/materials for organ-on-a-chip platforms;
  • High-throughput in vitro platforms for drug screening applications;
  • Biosensor integration with in vitro models;
  • Advanced stimuli-responsive material applications for in vitro models;
  • 3D bioprinting applications for organ-on-a-chip platforms.

Dr. Rohollah Nasiri
Dr. Mohammadreza Nikmaneshi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • in vitro tissue models
  • microfluidics
  • organ on a chip
  • sensors
  • microphysiological sensors
  • lab-on-a-chip
  • drug screening
  • disease modeling
  • 3D bioprinting

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Related Special Issue

Published Papers (3 papers)

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Research

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16 pages, 9379 KiB  
Article
Activation and Expansion of Human T-Cells Using Microfluidic Devices
by Ana Belén Peñaherrera-Pazmiño, Gustavo Rosero, Dario Ruarte, Julia Pinter, Karla Vizuete, Maximiliano Perez, Marie Follo, Betiana Lerner and Roland Mertelsmann
Biosensors 2025, 15(5), 270; https://doi.org/10.3390/bios15050270 - 25 Apr 2025
Abstract
Treatment of cancer patients with autologous T-cells expressing a chimeric antigen receptor (CAR) is one of the most promising therapeutic modalities for hematological malignancy treatment. For this treatment, primary T-cell expansion is needed. Microfluidic technologies can be used to better understand T-cell activation [...] Read more.
Treatment of cancer patients with autologous T-cells expressing a chimeric antigen receptor (CAR) is one of the most promising therapeutic modalities for hematological malignancy treatment. For this treatment, primary T-cell expansion is needed. Microfluidic technologies can be used to better understand T-cell activation and proliferation. Microfluidics have had a meaningful impact in the way experimental biology and biomedical research are approached in general. Furthermore, microfluidic technology allows the generation of large amounts of data and enables the use of image processing for analysis. However, one of the major technical hurdles involved in growing suspension cells under microfluidic conditions is their immobilization, to avoid washing them out of the microfluidic chip during medium renewal. In this work, we use a multilevel microfluidic chip to successfully capture and immobilize suspension cells. Jurkat cells and T-cells are isolated through traps to microscopically track their development and proliferation after activation over a period of 8 days. The T-cell area of four independent microchannels was compared and there is no statistically significant difference between them (ANOVA p-value = 0.976). These multilevel microfluidic chips provide a new method of studying T-cell activation. Full article
(This article belongs to the Special Issue Microfluidics and Organ-on-a-Chip for Disease Modeling and Drug Screening (2nd Edition))
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Review

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43 pages, 7519 KiB  
Review
Bone-on-a-Chip Systems for Hematological Cancers
by Gül Kozalak and Ali Koşar
Biosensors 2025, 15(3), 176; https://doi.org/10.3390/bios15030176 - 9 Mar 2025
Viewed by 847
Abstract
Hematological malignancies originating from blood, bone marrow, and lymph nodes include leukemia, lymphoma, and myeloma, which necessitate the use of a distinct chemotherapeutic approach. Drug resistance frequently complicates their treatment, highlighting the need for predictive tools to guide therapeutic decisions. Conventional 2D/3D cell [...] Read more.
Hematological malignancies originating from blood, bone marrow, and lymph nodes include leukemia, lymphoma, and myeloma, which necessitate the use of a distinct chemotherapeutic approach. Drug resistance frequently complicates their treatment, highlighting the need for predictive tools to guide therapeutic decisions. Conventional 2D/3D cell cultures do not fully encompass in vivo criteria, and translating disease models from mice to humans proves challenging. Organ-on-a-chip technology presents an avenue to surmount genetic disparities between species, offering precise design, concurrent manipulation of various cell types, and extrapolation of data to human physiology. The development of bone-on-a-chip (BoC) systems is crucial for accurately representing the in vivo bone microenvironment, predicting drug responses for hematological cancers, mitigating drug resistance, and facilitating personalized therapeutic interventions. BoC systems for modeling hematological cancers and drug research can encompass intricate designs and integrated platforms for analyzing drug response data to simulate disease scenarios. This review provides a comprehensive examination of BoC systems applicable to modeling hematological cancers and visualizing drug responses within the intricate context of bone. It thoroughly discusses the materials pertinent to BoC systems, suitable in vitro techniques, the predictive capabilities of BoC systems in clinical settings, and their potential for commercialization. Full article
(This article belongs to the Special Issue Microfluidics and Organ-on-a-Chip for Disease Modeling and Drug Screening (2nd Edition))
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21 pages, 5531 KiB  
Review
Recapitulating Glioma Stem Cell Niches Using 3D Spheroid Models for Glioblastoma Research
by Hyunji Jo, Seulgi Lee, Min-Hyeok Kim, Sungsu Park and Seo-Yeon Lee
Biosensors 2024, 14(11), 539; https://doi.org/10.3390/bios14110539 - 7 Nov 2024
Cited by 1 | Viewed by 2244
Abstract
Glioblastoma multiforme (GBM) is among the most aggressive brain cancers, and it contains glioma stem cells (GSCs) that drive tumor initiation, progression, and recurrence. These cells resist conventional therapies, contributing to high recurrence rates in GBM patients. Developing in vitro models that mimic [...] Read more.
Glioblastoma multiforme (GBM) is among the most aggressive brain cancers, and it contains glioma stem cells (GSCs) that drive tumor initiation, progression, and recurrence. These cells resist conventional therapies, contributing to high recurrence rates in GBM patients. Developing in vitro models that mimic the tumor microenvironment (TME), particularly the GSC niche, is crucial for understanding GBM growth and therapeutic resistance. Three-dimensional (3D) spheroid models provide a more physiologically relevant approach than traditional two-dimensional (2D) cultures, recapitulating key tumor features like hypoxia, cell heterogeneity, and drug resistance. This review examines scaffold-free and scaffold-based methods for generating 3D GBM spheroids, focusing on their applications in studying the cancer stem cell niche. The discussion encompasses methods such as the hanging drop, low-adhesion plates, and magnetic levitation, alongside advancements in embedding spheroids within extracellular matrix-based hydrogels and employing 3D bioprinting to fabricate more intricate tumor models. These 3D culture systems offer substantial potential for enhancing our understanding of GBM biology and devising more effective targeted therapies. Full article
(This article belongs to the Special Issue Microfluidics and Organ-on-a-Chip for Disease Modeling and Drug Screening (2nd Edition))
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