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Biosensors
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Feature Paper in Biosensor and Bioelectronic Devices 2024
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Feature Paper in Biosensor and Bioelectronic Devices 2024

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4439

Special Issue Editor

Prof. Dr. Benoît Piro

E-Mail Website
Guest Editor
Chemistry Department, University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS 15 rue J-A de Baïf, 75205 Paris, CEDEX 13, France
Interests: bioelectrochemistry; biosensors; bioelectronics; transistor; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Feature Paper in Biosensor and Bioelectronic Devices 2024”, represents an expanding disciplinary field that combines biosensors with various emerging technologies. This Special Issue’s scope includes, but is not limited to, the design, development, and application of biosensors (enzyme sensors, immunosensors, DNA/RNA sensors, etc.) and bioelectronic devices (electronic nose, electronic tongue, implantable electronics, etc.) in the biological, medical, environmental and industrial fields, with an emphasis on matters of worldwide interest.

Prof. Dr. Benoît Piro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro electro mechanical systems (MEMS)
  • optical biosensors
  • nanotechnology in biosensors
  • flexible and wearable biosensors
  • portable biosensors

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Published Papers (3 papers)

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Research

10 pages, 2607 KiB  
Communication
Optical Interferometric Device for Rapid and Specific Detection of Biological Cells
by Sándor Valkai, Dániel Petrovszki, Zsombor Fáskerti, Margaréta Baumgärtner, Brigitta Biczók, Kira Dakos, Kevin Dósa, Berill B. Kirner, Anna E. Kocsis, Krisztina Nagy, István Andó and András Dér
Biosensors 2024, 14(9), 421; https://doi.org/10.3390/bios14090421 - 29 Aug 2024
Viewed by 845
Abstract
Here, we report a rapid and accurate optical method for detecting cells from liquid samples in a label-free manner. The working principle of the method is based on the interference of parts of a conical laser beam, coming from a single-mode optical fiber [...] Read more.
Here, we report a rapid and accurate optical method for detecting cells from liquid samples in a label-free manner. The working principle of the method is based on the interference of parts of a conical laser beam, coming from a single-mode optical fiber directly, and reflected from a flat glass surface. The glass is functionalized by antibodies against the cells to be detected from the liquid sample. Cells bound to that surface modify the reflected beam, and hence, change the resulting interference pattern, too. By registering and interpreting the variation in the image, the presence of cells from the sample can be detected. As for a demonstration, cell suspensions from a U937 cell line were used in glass chambers functionalized by antibodies (TMG6-5 (mIgG1)) to which the cells specifically bind. The limit of detection (LOD) of the method was also estimated. This proof-of-concept setup offers a cost-effective and easy-to-use way of rapid and specific detection of any type of cells (including pathogens) from suspensions (e.g., body fluids). The possible portability of the device predicts its applicability as a rapid test in clinical diagnostics. Full article
(This article belongs to the Special Issue Feature Paper in Biosensor and Bioelectronic Devices 2024)
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10 pages, 2573 KiB  
Article
A 3D-Printed Do-It-Yourself ELISA Plate Reader as a Biosensor Tested on TNFα Assay
by Miroslav Pohanka, Ondřej Keresteš and Jitka Žáková
Biosensors 2024, 14(7), 331; https://doi.org/10.3390/bios14070331 - 6 Jul 2024
Cited by 2 | Viewed by 1027
Abstract
Simple analytical devices suitable for the analysis of various biochemical and immunechemical markers are highly desirable and can provide laboratory diagnoses outside standard hospitals. This study focuses on constructing an easily reproducible do-it-yourself ELISA plate reader biosensor device, assembled from generally available and [...] Read more.
Simple analytical devices suitable for the analysis of various biochemical and immunechemical markers are highly desirable and can provide laboratory diagnoses outside standard hospitals. This study focuses on constructing an easily reproducible do-it-yourself ELISA plate reader biosensor device, assembled from generally available and inexpensive parts. The colorimetric biosensor was based on standard 96-well microplates, 3D-printed parts, and a smartphone camera as a detector was utilized here as a tool to replace the ELISA method, and its function was illustrated in the assay of TNFα as a model immunochemical marker. The assay provided a limit of detection of 19 pg/mL when the B channel of the RGB color model was used for calibration. The assay was well correlated with the ELISA method, and no significant matrix effect was observed for standard biological samples or interference of proteins expected in a sample. The results of this study will inform the development of simple analytical devices easily reproducible by 3D printing and found on generally available electronics. Full article
(This article belongs to the Special Issue Feature Paper in Biosensor and Bioelectronic Devices 2024)
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14 pages, 2533 KiB  
Article
Soft-Template-Based Manufacturing of Gold Nanostructures for Energy and Sensing Applications
by Tushar Kanti Maiti, Wanli Liu, Asghar Niyazi, Adam M. Squires, Sujay Chattpoadhyay and Mirella Di Lorenzo
Biosensors 2024, 14(6), 289; https://doi.org/10.3390/bios14060289 - 3 Jun 2024
Viewed by 741
Abstract
Implantable and wearable bioelectronic systems can enable tailored therapies for the effective management of long-term diseases, thus minimising the risk of associated complications. In this context, glucose fuel cells hold great promise as in- or on-body energy harvesters for ultra-low-power bioelectronics and as [...] Read more.
Implantable and wearable bioelectronic systems can enable tailored therapies for the effective management of long-term diseases, thus minimising the risk of associated complications. In this context, glucose fuel cells hold great promise as in- or on-body energy harvesters for ultra-low-power bioelectronics and as self-powered glucose sensors. We report here the generation of gold nanostructures through a gold electrodeposition method in a soft template for the abiotic electrocatalysis of glucose in glucose fuel cells. Two different types of soft template were used: a lipid cubic phase-based soft template composed of Phytantriol and Brij®-56, and an emulsion-based soft template composed of hexane and sodium dodecyl sulphate (SDS). The resulting gold structures were first characterised by SAXS, SEM and TEM to elucidate their structure, and then their electrocatalytic activity towards glucose was compared in both a three-electrode set-up and in a fuel cell set-up. The Phytantriol/Brij®-56 template led to a nanofeather-like Au structure, while the hexane/SDS template led to a nanocoral-like Au structure. These templated electrodes exhibited similar electrochemical active surface areas (0.446 cm2 with a roughness factor (RF) of 14.2 for Phytantriol/Brij®-56 templated nanostructures and 0.421 cm2 with an RF of 13.4 for hexane/SDS templated nanostructures), and a sensitivity towards glucose of over 7 μA mM−1 cm−2. When tested as the anode of an abiotic glucose fuel cell (in a phosphate-buffered solution with a glucose concentration of 6 mM), a maximum power density of 7 μW cm−2 was reached; however the current density in the case of the fuel cell with the Phytantriol/Brij®-56 templated anode was approximately two times higher, reaching the value of 70 μA cm−2. Overall, this study demonstrates two simple, cost-effective and efficient strategies to manipulate the morphology of gold nanostructures, and thus their catalytic property, paving the way for the successful manufacturing of functional abiotic glucose fuel cells. Full article
(This article belongs to the Special Issue Feature Paper in Biosensor and Bioelectronic Devices 2024)
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