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Biosensors
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Recent Advances in Optical Fiber Biosensor
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Recent Advances in Optical Fiber Biosensor

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4474

Special Issue Editors

Dr. Yuzhi Chen

E-Mail Website
Guest Editor
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Interests: biosensors; optical fiber sensing technology; surface plasmon resonance detection technology; optical interference detection technology; immunology detection; fluorescence detection
Prof. Dr. Jing Yong Ye

E-Mail Website
Guest Editor
Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA
Interests: biomedical optics; nanobiotechnology; label-free bioassays; photonic-crystal biosensor; in vivo fiber-optic fluorescence biosensing; photoacoustic imaging; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue is optical fiber biosensors as miniaturized devices for sensitive and specific detection of chemical and biological samples in different fields, including biomedical research and applications, life sciences, healthcare, food safety, and environmental monitoring.

Optical fiber biosensors have several important features, including low loss, which enables long-distance signal transmission; low cost, which enables manufacturing disposable biosensors to effectively avoid cross-contamination; anti-electromagnetic interference abilities, which enable detection in environments with strong electromagnetic interference such as that caused by nuclear magnetic resonance; and good compactness and biocompatibility, which enable in vivo detection. Moreover, optical fiber biosensors can facilitate various sensing functions through different sensing principles and structure designs, as specific detection of target molecules can be achieved through surface functionalization.

Any contributions of a paper related to fiber optical biosensors are welcome to this Special Issue, including new trends in the design of biosensors, new methods to improve the sensor performance, biological detection applications of the biosensors, and optimization of optical fiber detection system.

If you are interested in submitting a manuscript, or if you have any questions, please contact us.

Dr. Yuzhi Chen
Prof. Dr. Jing Yong Ye
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surface plasmon resonance
  • optical fiber biosensor
  • immunology detection
  • disposable biosensors
  • specific detection
  • healthcare monitoring
  • environmental monitoring
  • immobilization techniques

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Published Papers (2 papers)

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12 pages, 12196 KiB  
Article
Tapered Fiber Bioprobe Based on U-Shaped Fiber Transmission for Immunoassay
by Xinghong Chen, Lei Xiao, Xuejin Li, Duo Yi, Jinghan Zhang, Hao Yuan, Zhiyao Ning, Xueming Hong and Yuzhi Chen
Biosensors 2023, 13(10), 940; https://doi.org/10.3390/bios13100940 - 20 Oct 2023
Cited by 2 | Viewed by 1850
Abstract
In this paper, a tapered fiber bioprobe based on Mach–Zehnder interference (MZI) is proposed. To retain the highly sensitive straight-tapered fiber MZI sensing structure, we designed a U-shaped transmission fiber structure for the collection of optical sensing signals to achieve a miniature-insert-probe design. [...] Read more.
In this paper, a tapered fiber bioprobe based on Mach–Zehnder interference (MZI) is proposed. To retain the highly sensitive straight-tapered fiber MZI sensing structure, we designed a U-shaped transmission fiber structure for the collection of optical sensing signals to achieve a miniature-insert-probe design. The spectrum responses from the conventional straight-tapered fiber MZI sensor and our proposed sensor were compared and analyzed, and experimental results showed that our proposed sensor not only has the same sensing capability as the straight-tapered fiber sensor, but also has the advantages of being flexible, convenient, and less liquid-consuming, which are attributed to the inserted probe design. The tapered fiber bioprobe obtained a sensitivity of 1611.27 nm/RIU in the refractive index detection range of 1.3326–1.3414. Finally, immunoassays for different concentrations of human immunoglobulin G were achieved with the tapered fiber bioprobe through surface functionalization, and the detection limit was 45 ng/mL. Our tapered fiber bioprobe has the insert-probe advantages of simpleness, convenience, and fast operation. Simultaneously, it is low-cost, highly sensitive, and has a low detection limit, which means it has potential applications in immunoassays and early medical diagnosis. Full article
(This article belongs to the Special Issue Recent Advances in Optical Fiber Biosensor)
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12 pages, 8104 KiB  
Article
Mode-Coupling Generation Using ITO Nanodisk Arrays with Au Substrate Enabling Narrow-Band Biosensing
by Shuwen Chu, Yuzhang Liang, Mengdi Lu, Huizhen Yuan, Yi Han, Jean-Francois Masson and Wei Peng
Biosensors 2023, 13(6), 649; https://doi.org/10.3390/bios13060649 - 14 Jun 2023
Cited by 2 | Viewed by 1890
Abstract
Plasmonic metal nanostructures have promising applications in biosensing due to their ability to facilitate light–matter interaction. However, the damping of noble metal leads to a wide full width at half maximum (FWHM) spectrum which restricts sensing capabilities. Herein, we present a novel non-full-metal [...] Read more.
Plasmonic metal nanostructures have promising applications in biosensing due to their ability to facilitate light–matter interaction. However, the damping of noble metal leads to a wide full width at half maximum (FWHM) spectrum which restricts sensing capabilities. Herein, we present a novel non-full-metal nanostructure sensor, namely indium tin oxide (ITO)–Au nanodisk arrays consisting of periodic arrays of ITO nanodisk arrays and a continuous gold substrate. A narrow-band spectral feature under normal incidence emerges in the visible region, corresponding to the mode-coupling of surface plasmon modes, which are excited by lattice resonance at metal interfaces with magnetic resonance mode. The FWHM of our proposed nanostructure is barely 14 nm, which is one fifth of that of full-metal nanodisk arrays, and effectively improves the sensing performance. Furthermore, the thickness variation of nanodisks hardly affects the sensing performance of this ITO-based nanostructure, ensuring excellent tolerance during preparation. We fabricate the sensor ship using template transfer and vacuum deposition techniques to achieve large-area and low-cost nanostructure preparation. The sensing performance is used to detect immunoglobulin G (IgG) protein molecules, promoting the widespread application of plasmonic nanostructures in label-free biomedical studies and point-of-care diagnostics. The introduction of dielectric materials effectively reduces FWHM, but sacrifices sensitivity. Therefore, utilizing structural configurations or introducing other materials to generate mode-coupling and hybridization is an effective way to provide local field enhancement and effective regulation. Full article
(This article belongs to the Special Issue Recent Advances in Optical Fiber Biosensor)
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