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Biosensors
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Advanced Materials in Nano-Photonics and Biosensor Systems
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Advanced Materials in Nano-Photonics and Biosensor Systems

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 10131

Special Issue Editors

Dr. Akhilesh Pathak

E-Mail Website
Guest Editor
Center for Smart Structures and Materials, Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
Interests: fiber bragg gratings (FBG); PCF; sensors; plasmonic; waveguide; optical fibers; optical fiber sensor; finite element method; FEM; simulation; SPR; FBG; MOF; Volatile Organic Compound (VOC); COMSOL; health; biosensors
Special Issues, Collections and Topics in MDPI journals
Dr. Rajavel Krishnamoorthy

E-Mail Website
Guest Editor
Department of Industrial and Manufacturing Systems Engineering, Kansas State University, Manhattan, KS 66502, USA
Interests: nanomaterials; MXene; graphene; ink; additive manufacturing; sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The integration of nanotechnology with advancements in modern photonics possesses the potential to significantly impact various application areas, particularly in medical research and diagnostics. These nanomaterials exhibit exceptional thermal, electrical, mechanical, and optical properties that are not present at the microscale. When combined with other materials to form 'nanocomposites', they often deliver superior performance compared to bulk materials—offering increased strength, improved thermal and electrical conductivity, and enhanced optical, magnetic, and biosensing capabilities. The potential of these advanced materials is further unlocked when integrated with microphotonic devices, paving the way for novel research opportunities and applications across materials science, engineering, chemistry, physics, biology, and the field of biosensors.

This Special Issue focuses on the latest advancements in the development of such materials and nanocomposites, covering their application in sensing and biosensing. We strongly encourage individuals interested in contributing original research and review papers on relevant topics—including, but not limited to, those outlined in this Special Issue—to submit their work for publication.

  • Nanocomposite synthesis techniques
  • Nanomaterials in biosensor development
  • Integration of nanomaterials with advanced photonics
  • Advanced biosensing strategies using nanocomposites
  • Applications of nanomaterials in environmental monitoring
  • Nanomaterials for healthcare and diagnostic applications
  • Safety and environmental impact of nanocomposites
  • Simulation and FEM modeling

Dr. Akhilesh Pathak
Dr. Rajavel Krishnamoorthy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosensing
  • nanocomposites
  • microphotonic devices
  • thermal conductivity

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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16 pages, 4169 KB  
Article
Evaluating Normalization Methods for Robust Spectral Performance Assessments of Hyperspectral Imaging Cameras
by Siavash Mazdeyasna, Mohammed Shahriar Arefin, Andrew Fales, Silas J. Leavesley, T. Joshua Pfefer and Quanzeng Wang
Biosensors 2025, 15(1), 20; https://doi.org/10.3390/bios15010020 - 4 Jan 2025
Cited by 17 | Viewed by 5661
Abstract
Hyperspectral imaging (HSI) technology, which offers both spatial and spectral information, holds significant potential for enhancing diagnostic performance during endoscopy and other medical procedures. However, quantitative evaluation of HSI cameras is challenging due to various influencing factors (e.g., light sources, working distance, and [...] Read more.
Hyperspectral imaging (HSI) technology, which offers both spatial and spectral information, holds significant potential for enhancing diagnostic performance during endoscopy and other medical procedures. However, quantitative evaluation of HSI cameras is challenging due to various influencing factors (e.g., light sources, working distance, and illumination angle) that can alter the reflectance spectra of the same target as these factors vary. Towards robust, universal test methods, we evaluated several data normalization methods aimed at minimizing the impact of these factors. Using a high-resolution HSI camera, we measured the reflectance spectra of diffuse reflectance targets illuminated by two different light sources. These spectra, along with the reference spectra from the target manufacturer, were normalized with nine different methods (e.g., area under the curve, standard normal variate, and centering power methods), followed by a uniform scaling step. We then compared the measured spectra to the reference to evaluate the capability of each normalization method in ensuring a consistent, standardized performance evaluation. Our results demonstrate that normalization can mitigate the impact of some factors during HSI camera evaluation, with performance varying across methods. Generally, noisy spectra pose challenges for normalization methods that rely on limited reflectance values, while methods based on reflectance values across the entire spectrum (such as standard normal variate) perform better. The findings also suggest that absolute reflectance spectral measurements may be less effective for clinical diagnostics, whereas normalized spectral measurements are likely more appropriate. These findings provide a foundation for standardized performance testing of HSI-based medical devices, promoting the adoption of high-quality HSI technology for critical applications such as early cancer detection. Full article
(This article belongs to the Special Issue Advanced Materials in Nano-Photonics and Biosensor Systems)
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10 pages, 2982 KB  
Communication
Preliminary Investigation of a Potential Optical Biosensor Using the Diamond™ Nucleic Acid Dye Applied to DNA and Friction Ridge Analysis from Fingerprint Traces
by Martyna Czarnomska, Aneta Lewkowicz, Emilia Gruszczyńska, Katarzyna Walczewska-Szewc, Zygmunt Gryczyński, Piotr Bojarski and Sławomir Steinborn
Biosensors 2024, 14(11), 546; https://doi.org/10.3390/bios14110546 - 11 Nov 2024
Cited by 4 | Viewed by 2702
Abstract
Developments in science and technology lead to an increasing use of scientific evidence in litigation. Interdisciplinary research can improve current procedures and introduce new ones for the disclosure and examination of evidence. The dactyloscopic trace is used for personal identification by matching minutiae [...] Read more.
Developments in science and technology lead to an increasing use of scientific evidence in litigation. Interdisciplinary research can improve current procedures and introduce new ones for the disclosure and examination of evidence. The dactyloscopic trace is used for personal identification by matching minutiae (the minimum required may vary by country) or for extracting DNA material from the trace under investigation. The research presented in this article aims to propose the merging of two currently used personal identification methods, DNA analysis and dactyloscopic trace analysis, which are currently treated as separate forensic traces found at a crime scene. Namely, the forensic trace to be analyzed is the dactyloscopic trace containing DNA, and both sources of information needed for identification are examined as one. Promega’s Diamond™ Nucleic Acid Dye, presented as a safe alternative to ethidium bromide, works by binding to single- and double-stranded DNA and is used to visualize the separation of material in a gel and to detect DNA in forensic samples. Spectroscopic studies as absorption and emission spectra and fluorescence microscopy observations presented in our research confirm that Diamond™ Nucleic Acid Dye can also be used to visualize fingerprints on non-absorbent surfaces and that combining the two methods into one can significantly increase the evidential value and contribute to the design of an innovative fast-acting optical biosensor. Full article
(This article belongs to the Special Issue Advanced Materials in Nano-Photonics and Biosensor Systems)
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Review

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29 pages, 6255 KB  
Review
Recent Advances in Metal–Organic Framework-Based Nanozymes for Enhanced Biosensing Applications
by Jianping Wang, Xiaoying Zhou, Zhonghao Dai, Lu Xu, Siyu Nie, Dongjie Yang, Yi Yang, Liyuan Wang, Jiayun Yao and Zihong Ye
Biosensors 2026, 16(4), 197; https://doi.org/10.3390/bios16040197 - 1 Apr 2026
Viewed by 836
Abstract
In recent years, with the rapid development of materials science, there has been a significant increase in the focus on nanozymes. Metal–organic framework (MOF)-based nanozymes are a class of porous organic–inorganic coordination materials capable of mimicking the catalytic activity center of natural enzymes. [...] Read more.
In recent years, with the rapid development of materials science, there has been a significant increase in the focus on nanozymes. Metal–organic framework (MOF)-based nanozymes are a class of porous organic–inorganic coordination materials capable of mimicking the catalytic activity center of natural enzymes. The properties of MOF-based nanozymes include high specific surface area and porosity, structural diversity and customizability, and excellent catalytic activity and stability. Through rational design, the activity of MOF-based nanozymes can be further enhanced to promote their application in biosensing and other fields. This paper systematically investigates the intrinsic relationship between the structure of MOFs and their catalytic performance, with a focus on the diverse catalytic activities of MOF-based nanozymes, including peroxidase, oxidase, catalase, superoxide dismutase, and hydrolase. It reviews optimization strategies for the key parameters, such as selectivity and stability, summarizing the advances in synthesis strategies. Furthermore, the application progress of MOF-based nanozymes in the field of biosensing is reviewed, covering areas such as biomarker detection, virus recognition, and the screening of pathogenic microorganisms, among others. This review provides a systematic discussion of the opportunities and challenges in the development of MOF-based nanozymes, identifies the key scientific issues that are driving the field forward, and offers important references for optimizing MOFs’ structural designs and developing high-efficiency biochemical sensors. Full article
(This article belongs to the Special Issue Advanced Materials in Nano-Photonics and Biosensor Systems)
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