Biosensors for Nucleic Acid Biomarkers

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4002

Special Issue Editor

School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China
Interests: genetics biomarkers analysis; nucleic acid amplification technology; protease activity analysis; single-cell/single-molecule analysis; next-generation sequencing

Special Issue Information

Dear Colleagues,

Nucleic acid detection plays an important role in the rapid screening of cancers and early diagnosis of infectious diseases. Revolutionary advances in genome sequencing and nucleic acid biology over the past 15 years have resulted in an explosion of data and knowledge about the identity, function, and regulation of cellular DNA and RNA. This insight is increasingly harnessed for applications in molecular biology, biotechnology, and medicine. In parallel with these advances, there has been a growing need for techniques that enable the detection of nucleic acids.

Today, various nucleic acid biosensors have been widely used in biological applications, clinical diagnostics, environmental analysis, food safety, and forensic analysis. In this Special Issue, we welcome communications, full papers, and focused reviews on topics that pertain to the use of reporter-modified oligonucleotides and analogs thereof for the detection of nucleic acids and other biomolecules.

This issue will include but not be limited to the following topics:

(1) New nucleic acid amplification methods;

(2) Naked-eye analysis strategies for nucleic acid;

(3) CRISPR/Cas-based toolboxes;

(4) Point-of-care methods for nucleic acid biomarkers;

(5) Single-cell/molecule analysis;

(6) Lab on a chip/single microbead.

Dr. Hui Wang
Guest Editor

Manuscript Submission Information

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Keywords

  • point-of-care testing
  • CRISPR/Cas sensing toolbox
  • nucleic acid amplification technologies
  • single-cell/molecule analysis
  • lab on a chip
  • lab on a single microbead

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Published Papers (1 paper)

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15 pages, 2754 KiB  
Perspective
A Short Review on Miniaturized Biosensors for the Detection of Nucleic Acid Biomarkers
by Madhusudan B. Kulkarni, Narasimha H. Ayachit and Tejraj M. Aminabhavi
Biosensors 2023, 13(3), 412; https://doi.org/10.3390/bios13030412 - 22 Mar 2023
Cited by 16 | Viewed by 3547
Abstract
Even today, most biomarker testing is executed in centralized, dedicated laboratories using bulky instruments, automated analyzers, and increased analysis time and expenses. The development of miniaturized, faster, low-cost microdevices is immensely anticipated for substituting for these conventional laboratory-oriented assays and transferring diagnostic results [...] Read more.
Even today, most biomarker testing is executed in centralized, dedicated laboratories using bulky instruments, automated analyzers, and increased analysis time and expenses. The development of miniaturized, faster, low-cost microdevices is immensely anticipated for substituting for these conventional laboratory-oriented assays and transferring diagnostic results directly onto the patient’s smartphone using a cloud server. Pioneering biosensor-based approaches might make it possible to test biomarkers with reliability in a decentralized setting, but there are still a number of issues and restrictions that must be resolved before the development and use of several biosensors for the proper understanding of the measured biomarkers of numerous bioanalytes such as DNA, RNA, urine, and blood. One of the most promising processes to address some of the issues relating to the growing demand for susceptible, quick, and affordable analysis techniques in medical diagnostics is the creation of biosensors. This article critically discusses a short review of biosensors used for detecting nucleic acid biomarkers, and their use in biomedical prognostics will be addressed while considering several essential characteristics. Full article
(This article belongs to the Special Issue Biosensors for Nucleic Acid Biomarkers)
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