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Brain Sciences
Special Issues
Unraveling the Neurobiology and Neuromodulation of Aggression and Violence
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Unraveling the Neurobiology and Neuromodulation of Aggression and Violence

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Behavioral Neuroscience".

Deadline for manuscript submissions: closed (1 April 2024) | Viewed by 1241

Special Issue Editor

Dr. Kyle Gobrogge

E-Mail Website
Guest Editor
Undergraduate Program in Neuroscience, Boston University, Boston, MA 02215, USA
Interests: behavioral neuroscience
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aggression is a common behavior in the animal kingdom used to establish dominance, social hierarchy, and acquire resources. While aggression is important for survival, it can also lead to extreme violence in humans. Therefore, it is crucial to understand the biological mechanisms and neuropeptide pathways behind aggression in order to develop effective treatments. This Special Issue will feature experts in the field discussing their research on aggression across multiple animal species. The goal is to identify biomarkers, neuropeptides and their pathways, and neuronal subtypes to better understand aggression and develop targeted therapies to regulate it.

Dr. Kyle Gobrogge
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aggression
  • violence
  • neurobiological therapies
  • optogenetics
  • DREADDs

Published Papers (1 paper)

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Research

19 pages, 6911 KiB  
Article
Oxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Danio rerio)
by Madalina-Andreea Robea, Georgiana Oprea, Gabriel Plavan, Mircea Nicusor Nicoara, Ioannis Mavroudis, Vasile Burlui and Alin Ciobica
Brain Sci. 2024, 14(3), 203; https://doi.org/10.3390/brainsci14030203 - 22 Feb 2024
Viewed by 907
Abstract
Autism spectrum disorder (ASD) has become one of the most well-known disorders encountered since early childhood among people. Nowadays, the main concerns are its high prevalence and the lack of proper therapeutic interventions. In this way, the necessity of using animal models that [...] Read more.
Autism spectrum disorder (ASD) has become one of the most well-known disorders encountered since early childhood among people. Nowadays, the main concerns are its high prevalence and the lack of proper therapeutic interventions. In this way, the necessity of using animal models that can mimic some of the spectrum symptoms, besides deepening the mechanisms of occurrence, is undeniable. Oxytocin (OT) is often mentioned and linked to producing social domain improvements. The goal of the present study was to determine if different time exposures to OT can trigger distinct behavioral responses in zebrafish, potentially offering insights into autism therapy. To accomplish this goal, zebrafish were exposed to the same dose of OT (33.2 ng/mL OT) for one week but with different time frames, such as: continuous exposure for seven days, fifteen minutes per day for seven days, and every two days for the same amount of time. The behavior of the fish was recorded using the EthoVision XT 11.5 software, and each trial lasted four minutes. Specific parameters for locomotor activity and aggressive behavior were measured. Overall, zebrafish exposure to OT generated several improvements in locomotor activity and aggressive behavior. Moreover, the differences in the exposure period indicated that time is an important factor, showing that continuous exposure to OT was linked with better performance than exposure to the hormone every two days. At the same time, the most variable results were observed in the case of fish exposed every day to OT. Exposure to OT could lead to certain improvements in zebrafish behavior that can be time-sensitive. Nevertheless, further work is needed in order to investigate the mechanisms of action of OT in an ASD context. Full article
(This article belongs to the Special Issue Unraveling the Neurobiology and Neuromodulation of Aggression and Violence)
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