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Brain Sciences
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Advancements and Future Directions in Clinical Psychosis
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Advancements and Future Directions in Clinical Psychosis

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: closed (10 February 2026) | Viewed by 4109

Special Issue Editors

Dr. Marco Colizzi

E-Mail Website
Guest Editor
Department of Medicine (DAME), University of Udine, 33100 Udine, UD, Italy
Interests: psychosis; neuropsychopharmacology; brain imaging; cannabinoids; cognitive neuroscience; prevention and early intervention in mental health
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Martinelli

E-Mail Website
Guest Editor
Unit of Epidemiological Psychiatry and Digital Mental Health, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Interests: rehabilitation; recovery; supported accommodation; social psychiatry; digital health; epidemiology

Special Issue Information

Dear Colleagues,

The Special Issue "Advancements and Future Directions in Clinical Psychosis" aims at addressinh the evolving landscape of psychosis research by highlighting recent breakthroughs and identifying critical challenges in clinical practice. Despite progress in neurobiological understanding, diagnostics, and therapeutic interventions, psychosis remains a complex and heterogeneous condition with significant unmet needs. Core problems include early detection, treatment resistance, and long-term functional outcomes. This collection seeks contributions that explore innovative diagnostic tools, personalized treatment strategies, neurocognitive and psychosocial approaches, and digital or AI-assisted interventions.

The scope encompasses original research, clinical trials, reviews, and translational studies focused on the schizophrenia spectrum and other psychotic disorders. Emphasis will be placed on interdisciplinary perspectives that bridge gaps between neuroscience, psychiatry, and public health.

Researchers, clinicians, and mental health professionals are encouraged to contribute their findings to foster collaborative advancement and shape future clinical frameworks. Through this mobilization, this Special Issue aspires to inform best practices and stimulate next-generation solutions in psychosis care.

You may choose our Joint Special Issue in JCM.

Dr. Marco Colizzi
Dr. Alessandra Martinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical psychosis
  • schizophrenia spectrum disorders
  • early detection of psychosis
  • treatment-resistant psychosis
  • long-term outcomes
  • personalized psychiatry
  • digital mental health
  • AI in psychiatry
  • neurocognitive interventions
  • psychosocial therapies
  • translational psychiatry
  • interdisciplinary mental health
  • psychosis clinical trials
  • innovative diagnostic tools

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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12 pages, 2676 KB  
Article
Temporal Dynamics of Auditory Evoked Neural Oscillations Under a Paired-Pulse Suppression Paradigm
by Tomosuke Nakano, Eishi Motomura, Kazuki Hisatomi, Yusuke Nakayama, Kanako Shinke, Takayasu Watanabe, Yasuhiro Kawano, Koji Inui and Motohiro Okada
Brain Sci. 2026, 16(2), 247; https://doi.org/10.3390/brainsci16020247 - 23 Feb 2026
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Abstract
Background/Objectives: Deficits in auditory change detection are well-known in psychiatric disorders such as schizophrenia. An abrupt change in sound feature during periodic sounds elicits both evoked potentials and a transient change in neural oscillations. Both of these cerebral responses are thought to reflect [...] Read more.
Background/Objectives: Deficits in auditory change detection are well-known in psychiatric disorders such as schizophrenia. An abrupt change in sound feature during periodic sounds elicits both evoked potentials and a transient change in neural oscillations. Both of these cerebral responses are thought to reflect the automatic change detection. However, the similarities and dissimilarities between these cerebral responses are unclear. To clarify them, we compared the temporal dynamics of evoked potentials and low gamma oscillations under a paired-pulse paradigm. Methods: Healthy adults (n = 21) participated. The stimulus was a 2 s sound consisting of a train of 25 ms pure tones. The sound pressure was increased by 15 dB twice within a 600 ms interval. Electroencephalographic signals were recorded from Fz and Cz electrodes referenced to linked mastoids. The peak (N100)-to-peak (P200) amplitude and the inter-trial phase coherence (ITPC) of low gamma oscillations were analyzed. Results: Auditory steady-state responses were evoked around 40 Hz. An abrupt change in sound pressure transiently decreased the ITPC of the oscillations at 40 Hz, whereas it increased the ITPC at the remaining frequencies. Unlike the change-related potentials, the degree of ITPC responses did not differ between the two changes. Conclusions: The synchrony of low gamma oscillations transiently responded to an abrupt increase in sound pressure but did not show paired-pulse suppression. This novel neurophysiological approach enables a focus on the neural change detection from multiple angles, which could be useful for investigations of psychiatric disorders. Full article
(This article belongs to the Special Issue Advancements and Future Directions in Clinical Psychosis)
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14 pages, 253 KB  
Article
Differential Effects of Art Therapy and Dance/Movement Therapy on Emotional and Somatic Regulation in Early Psychopathology: First-Episode Psychosis and Eating Disorders
by Annarita Vignapiano, Francesco Monaco, Claudio Malangone, Stefania Landi, Stefania Palermo, Naomi Gammella, Ilaria Pullano, Gaetano Pinto, Raffaele Malvone, Luigi Aruta, Luca Steardo, Jr. and Giulio Corrivetti
Brain Sci. 2026, 16(2), 211; https://doi.org/10.3390/brainsci16020211 - 11 Feb 2026
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Abstract
Background: Creative Expressive Therapies, including Art Therapy and Dance/Movement Therapy (DMT), are increasingly integrated as adjunctive interventions in the treatment of complex psychiatric conditions. However, comparative evidence regarding their differential effects across diagnostic groups remains limited. Methods: This exploratory quasi-experimental 2 × 2 [...] Read more.
Background: Creative Expressive Therapies, including Art Therapy and Dance/Movement Therapy (DMT), are increasingly integrated as adjunctive interventions in the treatment of complex psychiatric conditions. However, comparative evidence regarding their differential effects across diagnostic groups remains limited. Methods: This exploratory quasi-experimental 2 × 2 factorial study compared Art Therapy and DMT, delivered as adjuncts to treatment as usual, in patients with first-episode psychosis (FEP) and eating disorders (EDs) (N = 36). Participants received ten weekly group sessions. Changes in perceived well-being, emotional tension regulation, and physical tension regulation were assessed at baseline and post-intervention using self-report measures. Data were analyzed using repeated-measures ANOVA and linear mixed-effects models. Results: Significant pre–post improvements were observed across all outcome domains, indicating a transdiagnostic effect of Creative Expressive Therapies. Differential response patterns emerged according to clinical profile and therapeutic modality. DMT was associated with relatively greater improvements in physical tension regulation in patients with EDs, whereas Art Therapy showed relatively greater effects on emotional tension regulation in patients with FEP. Conclusions: Within the limitations of an exploratory, non-randomized design and the use of non-validated outcome measures, the findings suggest modality-specific patterns of response to Creative Expressive Therapies. These results should be considered hypothesis-generating and support further investigation through adequately powered randomized controlled trials employing validated clinical and neurobiological outcomes. Full article
(This article belongs to the Special Issue Advancements and Future Directions in Clinical Psychosis)

Other

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21 pages, 551 KB  
Systematic Review
Cognitive Remediation as a Tool for Enhancing Treatment Dimensions of Schizophrenic Symptomatology: A Systematic Review of Randomized Controlled Trials
by Maria Skokou, Panagiotis-Diogenis Stavridis, Aikaterini Ntoskou-Messini and Lambros Messinis
Brain Sci. 2025, 15(10), 1130; https://doi.org/10.3390/brainsci15101130 - 21 Oct 2025
Viewed by 2578
Abstract
Background/Objectives: Despite efforts, schizophrenia remains a difficult disease to treat for cognitive, positive, negative, and mood symptoms. In the present review, we explore existing data on the ameliorating effects of neurocognitive rehabilitation and the diverse symptomatology of the disorder. Methods: This [...] Read more.
Background/Objectives: Despite efforts, schizophrenia remains a difficult disease to treat for cognitive, positive, negative, and mood symptoms. In the present review, we explore existing data on the ameliorating effects of neurocognitive rehabilitation and the diverse symptomatology of the disorder. Methods: This systematic review has been registered with PROSPERO (registration number: CRD 420251154674). Following PRISMA guidelines, we conducted a search in PubMed, Scopus, and Science Direct database from inception to 14 July 2025. The methodological quality assessment was made by applying the Joanna Briggs Institute (JBI) critical appraisal tool for systematic reviews. Results: Of the 1001 records screened for eligibility, thirty-five studies were identified for data extraction and synthesis. Of these, seven had a low risk of bias, and seven had a high bias risk. The effects of cognitive remediation on the symptoms of schizophrenia were varied. There are consistently positive effects on negative symptoms, but the findings are mixed regarding other domains of symptomatology. The therapeutic effect on positive psychotic symptoms correlated with the severity of symptoms at baseline. Efficacy for mood and anxiety symptoms is controversial, with a comparable number of studies yielding contradicting results. Conclusions: Cognitive remediation has been shown to represent a significant therapeutic tool for schizophrenia symptoms. The method‘s efficacy seems well-established for negative symptoms, whereas the effects on positive psychotic, mood, and anxiety symptoms, although promising, are currently mixed. More high-quality research targeting patient populations where the symptoms studied are more prominent is needed to clarify the effectiveness of the intervention for distinct dimensions of schizophrenic symptomatology. Full article
(This article belongs to the Special Issue Advancements and Future Directions in Clinical Psychosis)
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