Alpha-Synuclein in Neurodegenerative Disorders: From Pathogenesis to Potential Therapies
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 1 February 2025 | Viewed by 52
Special Issue Editors
Interests: virus infection; neurodegeneration; protein aggregation; protein folding and mis-folding; diagnosis of neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: prions; protein aggregation; neurodegenerative diseases; protein biophysics; spectroscopy; protein biochemistry; phase separation
Special Issue Information
Dear Colleagues,
Neurodegenerative disorders, including Parkinson's disease, multiple system atrophy, Lewy body dementia, and other synucleinopathies, present a significant challenge to modern medicine due to their complex pathology and progressive nature. Central to the pathology of these disorders is the role of alpha-synuclein. The aggregation of alpha-synuclein has been implicated in neuronal dysfunction and death, contributing to the clinical manifestations of these diseases. Notably, alpha-synuclein pathology also connects with other neurodegenerative disorders, underscoring its significance as a target for research and therapeutic development.
This Special Issue of Brain Sciences aims to bring cutting-edge research and reviews that explore the multifaceted roles of alpha-synuclein in neurodegenerative disorders. We invite submissions that cover, but are not limited to, the following topics:
- Molecular mechanisms of alpha-synuclein aggregation and toxicity;
- Genetic and environmental factors influencing synucleinopathies;
- Alpha-synuclein as a biomarker for early diagnosis and progression of neurodegenerative diseases;
- Therapeutic strategies targeting alpha-synuclein pathology;
- Comparative studies of alpha-synuclein's role across different neurodegenerative disorders;
- Advances in imaging and tracking alpha-synuclein in vivo.
We welcome original research articles, comprehensive reviews, and insightful commentaries that contribute to this vital field of study.
Dr. Tuane C.R.G. Vieira
Dr. Yraima Cordeiro
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- alpha-synuclein
- neurodegenerative disorders
- synucleinopathies
- aggregation
- biomarkers
- therapeutic strategies
