Role of Non-coding RNAs in Regulation of Gene Expression in Neuroinflammation

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 2277

Special Issue Editor


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Guest Editor
Department of Biological Sciences, BITS Pilani Hyderabad Campus, Pilani, India
Interests: lncRNAs; miRNAs; circRNAs in neuroinflammation and cancer

Special Issue Information

Dear Colleagues,

The expression of regulatory non-coding RNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) is altered in several diseases of the central nervous system (CNS), such as neurodegenerative disorders, stroke, trauma, and infection. It has become clear that regulatory RNAs regulate pro-inflammatory and anti-inflammatory pathways in the CNS. They modulate cellular phenotypes and functions as regulators of gene expression during neuroinflammation by using diverse mechanisms through interactions with proteins, RNA, and DNA.

They have also emerged as attractive markers for diagnoses and targets for therapies for diseases in the CNS.

This Special Issue will focus on the molecular, cellular, and (pre)clinical aspects of miRNAs, lncRNAs, and circRNAs during neuroinflammation in CNS disorders. Authors are encouraged to submit their original research studies on this theme. Reviews that highlight new findings in the above areas are also welcome. Ι hope that this Special Issue will be of interest to the readers of Brain Sciences.

Dr. Vivek Sharma
Guest Editor

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Keywords

  • long non-coding RNAs (lncRNAs)
  • circular RNAs (circRNAs)
  • microRNAs (miRNAs)
  • microglia
  • NF-κB
  • neuroinflammation
  • astrocytes
  • neurons
  • Alzheimer’s disease
  • Parkinson’s disease
  • multiple sclerosis
  • amyotrophic lateral sclerosis
  • ischemia
  • spinal cord injury
  • neuropathic pain
  • neurovirology and neuroimmunology

Published Papers (1 paper)

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Review

26 pages, 1610 KiB  
Review
Role of Non-Coding RNAs in TGF-β Signalling in Glioma
by Bakhya Shree and Vivek Sharma
Brain Sci. 2023, 13(10), 1376; https://doi.org/10.3390/brainsci13101376 - 27 Sep 2023
Cited by 2 | Viewed by 1026
Abstract
Brain tumours and Gliomas, in particular, are among the primary causes of cancer mortality worldwide. Glioma diagnosis and therapy have not significantly improved despite decades of efforts. Autocrine TGF-β signalling promotes glioma proliferation, invasion, epithelial-to-mesenchymal transition (EMT), and drug resistance. Non-coding RNAs such [...] Read more.
Brain tumours and Gliomas, in particular, are among the primary causes of cancer mortality worldwide. Glioma diagnosis and therapy have not significantly improved despite decades of efforts. Autocrine TGF-β signalling promotes glioma proliferation, invasion, epithelial-to-mesenchymal transition (EMT), and drug resistance. Non-coding RNAs such as miRNA, lncRNA, and circRNAs have emerged as critical transcriptional and post-transcriptional regulators of TGF-β pathway components in glioma. Here, we summarize the complex regulatory network among regulatory ncRNAs and TGF-β pathway during Glioma pathogenesis and discuss their role as potential therapeutic targets for Gliomas. Full article
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