Deciphering Antioxidant Defence Mechanisms in Neuronal and Non-neuronal Cells

Dear Colleagues,

Throughout life, the brain is constantly exposed to injuries that can exacerbate degenerative processes and accelerate aging. Oxidative stress is a deleterious condition defined as the imbalance between oxidant and antioxidant defences leading to reactive oxygen species (ROS) generation, which oxidizes macromolecules such as lipids, proteins and nucleic acids causing cell death and leading to neurodegeneration. Therefore, cells have evolved defence mechanisms to limit oxidative stress damage and maintain redox homeostasis. Understanding the physiological function of brain cells in response to oxidative injuries, as well as how the crosstalk between neuronal and glial cells is influenced by this condition will be of fundamental importance for the development of new therapeutic interventions focused on limiting oxidative brain injury.

Therefore, in this Special Issue, we invite investigators to contribute with original research articles, as well as review articles focusing on the role of oxidative stress in the pathophysiology of brain aging and neurodegenerative disorders, highlighting the molecular mechanisms of antioxidant defence in neuronal and non-neuronal cells. Understanding the control of redox homeostasis in normal and pathological conditions will be of fundamental importance in tackling brain diseases.

Potential topics include, but are not limited to, the following:

• Molecular basis of oxidative stress on glial cells in the aging brain;
• Neurodegenerative diseases and oxidative stress: the role of glial cells;
• Effects of oxidative stress on lipid metabolism in neurodegenerative diseases;
• Mechanisms of hypoxia-induced oxidative stress in neuronal and non-neuronal cells in neurodegenerative diseases;
• Role of oxidative stress-induced autophagy in neuroprotection;
• Oxidative stress-induced microglial activation in brain aging and neurodegeneration;
• Discovery of novel synthetic antioxidants to limit oxidative stress in the brain;
• Molecular mechanisms of antioxidants in brain aging and neurodegeneration;
• Mechanisms of astrocyte reactivity to oxidative stress in the brain;
• Microglial activation and neurodegenerative diseases: understanding the molecular basis of oxidative stress;
• The role of astrocyte response to oxidative stress in BBB permeability.

Dr. Paolo Rosa
Dr. Alessio Crestini
Guest Editors

Manuscript Submission Information

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• oxidative stress
• reactive oxygen species
• ROS
• brain aging
• neurodegeneration
• neuronal loss
• hypoxia
• glial cells
• microglia
• antioxidants