Biology of Brain-Derived Neurotrophic Factor: Relevance for Disorders of the Central Nervous System
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Developmental Neuroscience".
Deadline for manuscript submissions: closed (20 November 2019) | Viewed by 8820
Special Issue Editor
Special Issue Information
Dear Colleagues,
Clinical, animal model, and molecular studies have shown that the Brain-Derived Neurotrophic Factor (BDNF) plays an important role in brain development, neuroplasticity, and cognition. Deficits in BDNF signalling have been implicated in several neurological and psychiatric disorders, and cumulative research suggests targeting BDNF signalling may be a viable treatment option. Already, it is clear that the mechanisms of action of clinically used drugs, such as antidepressants, may include changes in BDNF signalling. The effects of more directly targeting BDNF receptors are also being studied increasingly. Polymorphisms in the BDNF gene result in differential risk of CNS disorders, and it is possible that stratifying patient populations based on BDNF genetic profiles may enhance treatment success. The role of BDNF in brain function is often sex-specific and depends on the age and developmental stage of the subject.
Recent literature has shown rapid developments in pre-clinical and clinical research into the role of BDNF in the CNS, including the use of novel sophisticated animal models. This Special Issue comprises a series of review and research papers providing both an overview and update of the multi-factorial role of BDNF in the CNS.
Prof. Maarten van den Buuse
Guest Editor
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Keywords
- BDNF
- Neuroplasticity
- Brain development
- Cognition
- Depression
- Estrogen
- Val66met
- TrkB
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