Recurrent Stroke with Progressive Brain Metastasis and Immune Response
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 488
Special Issue Editors
Interests: stroke; neurotrauma
Interests: ischemic stroke and brain injury; neurovascular aneurysms; traumatic brain injury; stroke and vesicular trafficking; pediatric stroke and epilepsy; brain cancer (GBM) and brain metastasis; cognitive decline and neurodegeneration; neurodegeneration and AD; computational modeling (in-silico)
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Special Issue Information
Dear Colleagues,
The most prevalent type of adult brain tumors are those with metastases. The overall prognoses of cancer patients are becoming more and more dependent on brain metastases. The primary tumor, the immune system, and the microenvironment of the central nervous system interact in a complex way to cause brain metastasis from a peripheral tumor. Chemotherapies that would otherwise be successful in treating systemic cancer become ineffective when brain metastases are established because they invade behind the blood–brain barrier. The opportunity and importance of better comprehending the mechanisms of immunosuppression by tumors that spread to the brain, as well as the interaction between the brain environment and tumor, are brought on by the approval of immune checkpoint inhibitors for a number of common cancers, such as advanced melanoma and lung cancers. Stroke is also considered to be a major event for the initiation of the progressive inflammatory response, leading to apoptosis and permanent brain damage. Recurrent brain strokes create a inflammatory brain environment due to the activation of various immune responses, i.e., the activation of macrophages, and various ILs and CXCLs that alter brain homeostasis. Immune response plays a vital role and can cause a deadly outcome for such a pathology. The therapeutic advancements have been very minimal and require a lot of attention from basic to clinical translation research. This Special Issue is majorly focused on such preclinical and clinical studies that will lead to the translational scope in brain metastasis through the form of reviews, original research, and critical case reports.
Dr. Luis Rafael Moscote-Salazar
Dr. Vishal K Chavda
Guest Editors
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Keywords
- metastatic brain cancer
- strokes
- GBM
- immune response
- immunotherapy
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