Early Developmental Origins of Adult Neurodegenerative Syndromes
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Developmental Neuroscience".
Deadline for manuscript submissions: 15 February 2025 | Viewed by 47
Special Issue Editor
Interests: animal ecophysiology; chronobiology; developmental biology; psiconeuroimmune-endocrinology; reproductive biology; oncology; psychology; neuroscience; physiology; relativistic physics
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Special Issue Information
Dear Colleagues,
Conventionally, neurodegenerative syndromes have been regarded as the outcome of an unsuccessful aging process. However, this belief, deeply rooted in neuroscientific wisdom, is challenged by observations indicating that neurodegenerative syndromes initiate decades before they are identified; this is based on the clinical criteria used as a cardinal diagnostic reference. Thus, the presence of “nonspecific” prodromal symptoms 20 to 30 years before diagnosis implies that the onset of neurodegenerative syndromes predates even the appearance of prodromal symptoms, rendering them not merely conditions associated with aging but rather neurological developmental syndromes. In this volume, inspired by the theory that proclaims the Developmental Origins of Health and Disease (DOHaD) first articulated by David Barker, we invite researchers to submit original research and reviews that explore the developmental roots of neurodegenerative syndromes. Work that critically discusses evidence regarding pre and perinatal influences on adult neurodegenerative conditions is especially welcome.
Dr. Gabriel Gutiérrez-Ospina
Guest Editor
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Keywords
- DOHaD
- senescence
- maladaptive plasticity
- embodiment
- metabolic syndrome
- mitochondria
- gestation
- ontogeny
- developmental phenotype diversity
- developmental programing
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