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Brain Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Approaches to Prevent Neuropsychiatric Disorders Through the Control of Neuroinflammation

edited by Yoshikaszu Matsuda

submission deadline 15 Dec 2026 | 1 articles | Viewed by 770 | Submission Open

Keywords: neuroinflammation; Alzheimer's disease; microglia; neuroprotective effect; neuropsychiatric disorders; smoldering inflammation

(This special issue belongs to the Section Neurodegenerative Diseases)

Artificial Gravity and Neural Rehabilitation: From Mechanisms to Clinical Translation

edited by

Christos Frantzidis

and

Chrysoula Kourtidou-Papadeli

submission deadline 15 Dec 2026 | Viewed by 246 | Submission Open

Keywords: artificial gravity; centrifugation; microgravity countermeasures; sensorimotor adaptation; neuroplasticity; vestibular function; gait and balance rehabilitation; neurocognitive performance; spaceflight analogs (head-down tilt bed rest); translational neurorehabilitation

(This special issue belongs to the Section Neurorehabilitation)

The Biopsychology of Famine, Starvation, Hunger, and Eating Disorders

edited by

Julian Keenan

submission deadline 15 Dec 2026 | Viewed by 213 | Submission Open

Keywords: neuroscience; starvation; famine; hunger; anorexia; eating disorders; nutrition; brain

(This special issue belongs to the Section Neuropsychology)

New Insights on Emotion Regulation

edited by

Francesco Di Russo

and Francesca Strappini

submission deadline 18 Dec 2026 | Viewed by 327 | Submission Open

Keywords: emotion regulation; cognition; psychology

(This special issue belongs to the Section Neuropsychology)

Editorial Board Collection Series: Innovative Research in Molecular and Cellular Neuroscience for Regulation of Cell Death Mechanisms for Functional Neuroprotection

edited by

Swapan K. Ray

submission deadline 20 Dec 2026 | 4 articles | Viewed by 8332 | Submission Open

Keywords: apoptosis; autophagy; artificial intelligence; CRISPR; demyelination; ferroptosis; inflammasomes; microRNAs; necrosis; neuroprotection; organoids; PANoptosis; animal and cellular models of neurological diseases and injuries; proteases

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

The Neural Mechanisms of Reward Processing and Addictive Behaviors

edited by Mónica Méndez-Díaz and Javier Franco-Pérez

submission deadline 20 Dec 2026 | Viewed by 336 | Submission Open

Keywords: reward; addiction; mesolimbic pathway; ventral tegmental area; nucleus accumbens; hippocampus; dopamine; endocannabinoid system; substance use disorders; motivated behavior

(This special issue belongs to the Section Behavioral Neuroscience)

Advancing Cerebrovascular Care: From Translational Innovation to Patient-Centered Outcomes

edited by Muhammed Amir Essibayi

submission deadline 20 Dec 2026 | Viewed by 302 | Submission Open

Keywords: cerebrovascular disease; neuroendovascular therapy; flow diversion; chronic subdural hematoma; translational neuroscience; patient-centered outcomes; intravascular imaging; quality of life; stroke intervention; shared decision-making

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Omics Frontiers in Mental Health: From Mechanistic Insights to Precision Interventions

edited by

Kyle Burghardt

submission deadline 20 Dec 2026 | Viewed by 278 | Submission Open

Keywords: mental health; psychiatry; genomics; epigenomics; transcriptomics; proteomics; metabolomics; microbiome; multi-omics; biomarkers; precision psychiatry; machine learning; systems biology; treatment response; brain sciences

(This special issue belongs to the Section Neuropsychiatry)

Advances in Vision and Neuro-Ophthalmology: Retrospective and Perspective

edited by Roberto Paes-de-Carvalho, Sriparna Majumdar and

Luis Pérez de Sevilla Müller

submission deadline 20 Dec 2026 | Viewed by 214 | Submission Open

Keywords: ophthalmology; neurobiology of the eye; neurochemistry; photoreceptor physiology; vision; genomics of the eye; electroretinogram; development; pathophysiology of the eye

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Advances in Interoception: Theoretical, Experimental, and Clinical Perspectives

edited by

Laura Sagliano

and

Laura Catalano

submission deadline 20 Dec 2026 | Viewed by 199 | Submission Open

Keywords: interoception; interoceptive accuracy; awareness and sensibility; neuroimaging techniques in the study of interoception; neurostimulation techniques in the study of interoception; psychophysiology of interoception; interoception in clinical populations; assessment and intervention in interoception; theoretical models of interoception

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Digital Health and Sensory-Cognitive Aging: Evaluation Approaches and Co-Design for Inclusive Innovation

edited by Atul Jaiswal and Shikha Gupta

submission deadline 20 Dec 2026 | Viewed by 167 | Submission Open

Keywords: digital technologies; artificial intelligence; wearables; human-computer interaction; older adults; aging; sensory loss; sensory-cognitive impairments

(This special issue belongs to the Section Neural Engineering, Neuroergonomics and Neurorobotics)

Computational Intelligence and Brain Plasticity—2nd Edition

edited by

Gianluca Borghini

Alessandra Anzolin

, Riccardo Barbieri and

Bianca Maria Serena Inguscio

submission deadline 25 Dec 2026 | 1 articles | Viewed by 539 | Submission Open

Keywords: brain plasticity; learning process; cognitive training; mental state assessment; cognitive rehabilitation; high-resolution EEG; brain connectivity; cognitive control behaviour; artificial intelligence; hyperscanning; multivariate autoregressive models.

(This special issue belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)

Recent Advances in Biomarker Discovery: Are We Closer to Preventing or Slowing Parkinson’s Disease?

edited by Zoltan K. Mari

submission deadline 28 Dec 2026 | Viewed by 189 | Submission Open

Keywords: Parkinson’ s disease biomarkers; biological disease definition; prodromal and preclinical Parkinson’ s disease; trial enrichment and patient stratification; translational neurodegeneration research

(This special issue belongs to the Section Neurodegenerative Diseases)

New Trends in Neuroimaging and Cognition

edited by

Namhee Kim

and Roman Fleysher

submission deadline 30 Dec 2026 | Viewed by 255 | Submission Open

Keywords: longitudinal imaging analysis; structural and functional connectivity analysis; multimodal imaging analysis; multicenter imaging harmonization; image-based validation of tissue structure and function; image-guided therapy

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Advances in Dopamine and Cognition

edited by

Luca Aquili

submission deadline 31 Dec 2026 | 2 articles | Viewed by 7875 | Submission Open

Keywords: dopaminergic system; cognitive neuroscience; reinforcement learning; neuropsychopharmacology; motivation and decision making

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Educational Neuroscience: The Translation of Research Between Neuroscience and Education

edited by

Pedro Gil Madrona

Ramón García-Perales

and

Juan Simón-Piqueras

submission deadline 31 Dec 2026 | 2 articles | Viewed by 960 | Submission Open

Keywords: neurodivergence; educational inclusion; educational agent; school; learning; teaching; cognitive diversity; universal design for learning (UDL); inclusive practices; student participation

Cellular and Molecular Mechanisms Regulating Neuronal Function, Homeostasis, and Disease (2nd Edition)

edited by

Daniel José Barbosa

and

Ana Filipa Sobral

submission deadline 31 Dec 2026 | 1 articles | Viewed by 384 | Submission Open

Keywords: molecular mechanisms; cellular mechanisms; neuronal function; neuronal homeostasis; neuronal health; neuronal development; neuronal metabolism; neuron– glia interactions; synaptic plasticity; biomarkers of early diagnosis; neurodegeneration; brain diseases

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Expanding the Foundation of Evidence-Based Practice in Sensory Integration

edited by Sarah A. Schoen,

Shelly J. Lane

and Anita Bundy

submission deadline 31 Dec 2026 | Viewed by 267 | Submission Open

Keywords: sensory integration; sensory processing; neuroscience; assessment; intervention effectiveness; outcomes

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Noninvasive Brain Stimulation for Cognitive Enhancement

edited by Nicole R. Nissim

submission deadline 31 Dec 2026 | Viewed by 198 | Submission Open

Keywords: noninvasive brain stimulation (NIBS); cognitive aging; mild cognitive impairment (MCI); Alzheimer’ s disease and related dementias (AD/ADRD); neuromodulation; neuroimaging; cognitive intervention; biomarkers; electrophysiology; neuroplasticity

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Advances in Multisensory Integration and Neuromotor Control

edited by

Alice Witney

submission deadline 31 Dec 2026 | Viewed by 101 | Submission Open

Keywords: multisensory integration; neuromotor control; movement; embodied movement; sensory; vision; touch; proprioception

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Inflammation and Its Treatment in Spinal Cord Injury and Neurodegenerative Diseases

edited by Angélica Coyoy-Salgado,

Julio Morán

and

Julia Jeanett Segura-Uribe

submission deadline 10 Jan 2027 | 1 articles | Viewed by 882 | Submission Open

Keywords: spinal cord injury; neuroprotection; neurodegenerative diseases; oxidative stress; inflammatory biomarkers; neuroregeneration; therapeutic strategies

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Exploring the Cellular and Molecular Mechanisms Underlying Epilepsy

edited by Jerónimo Andrés Andrés Auzmendi

submission deadline 10 Jan 2027 | Viewed by 48 | Submission Open

Keywords: epilepsy; neuronal hyperexcitability; neuroinflammation; gut– brain axis; brain– periphery interactions

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Rethinking Neurodevelopmental Disorders: Beyond One-Size-Fits-All

edited by Salman Zubedat

submission deadline 15 Jan 2027 | 4 articles | Viewed by 8123 | Submission Open

Keywords: ADHD; autism; intellectual disability; communication disorders

(This special issue belongs to the Section Developmental Neuroscience)

The Interplay Between the Brain, Behavior and Immunity

edited by

Fatme Seval Ismail

submission deadline 15 Jan 2027 | 1 articles | Viewed by 790 | Submission Open

Keywords: behavior; therapy; drugs; immunity; neuroinflammation; neurological/psychiatric disorders; clinical studies; in vivo/in vitro models

(This special issue belongs to the Section Behavioral Neuroscience)

Cognitive Impairment in Multiple Sclerosis: Clinical Management, Neuroimaging and Therapeutic Approaches

edited by Marta Altieri

submission deadline 15 Jan 2027 | Viewed by 311 | Submission Open

Keywords: cognitive impairment; multiple sclerosis; neuropsychological evaluation; MRI; disease-modifying therapies

(This special issue belongs to the Section Systems Neuroscience)

Executive Functions and ADHD in Adults

edited by

Trinidad García

and

Celestino Rodriguez

submission deadline 15 Jan 2027 | Viewed by 241 | Submission Open

Keywords: ADHD; adults; executive functions; characteristics; evolution; impact; technology; society

(This special issue belongs to the Section Developmental Neuroscience)

Neuromodulation in Sensorimotor Control

edited by

Alice Witney

submission deadline 15 Jan 2027 | Viewed by 185 | Submission Open

Keywords: non-invasive neuromodulation; transcranial magnetic stimulation; transcranial ultrasound stimulation; sensorimotor control; visuomotor learning; touch; pain perception

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Insights and Innovations in Central Nervous System Barriers

edited by Jacquelyn A. Brown

submission deadline 20 Jan 2027 | Viewed by 275 | Submission Open

Keywords: central nervous system barriers; blood– brain barrier; blood– retinal barriers; blood– cerebrospinal fluid barrier; neurological disorders; in vitro and in vivo models; CNS infections

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Neurodevelopmental Outcomes in Pediatric HIV and HIV-Exposed Uninfected (HEU) Children

edited by

Mark Burke

submission deadline 20 Jan 2027 | Viewed by 134 | Submission Open

Keywords: pediatric HIV; HIV-exposed uninfected (HEU); neurodevelopmental outcomes; brain development; antiretroviral therapy (ART)

(This special issue belongs to the Section Developmental Neuroscience)

Brain Imaging Technologies for Advancing Explorations of Multiple Sclerosis

edited by Yunyan Zhang

submission deadline 25 Jan 2027 | Viewed by 217 | Submission Open

Keywords: brain imaging; magnetic resonance imaging; routine MRI; advanced MRI; image processing and analysis; artificial intelligence

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Augmented Reality and High-Resolution MRI in Brain Tumor Diagnosis and Treatment

edited by

Nicola Montemurro

submission deadline 30 Jan 2027 | Viewed by 201 | Submission Open

Keywords: augmented reality in neurosurgery; high-resolution MRI; brain tumor imaging; surgical navigation systems; image-guided surgery; 3D visualization for brain tumors; AI in tumor detection; precision neuro-oncology

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Neurocognitive Dysfunction Following Brain Injury: Advances and Challenges

edited by Xiaoying Sun

submission deadline 31 Jan 2027 | Viewed by 277 | Submission Open

Keywords: brain injury; neuroinflammation; glia cells; neuron– glia interaction; synaptic plasticity; cognitive dysfunction

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Brain Tumors: From Molecular Basis to Therapy: 2nd Edition

edited by Paolo Tini

submission deadline 31 Jan 2027 | Viewed by 114 | Submission Open

Keywords: brain tumors; molecular pathways; targeted therapy; diagnostic biomarkers; predictive biomarkers; therapeutic resistance

(This special issue belongs to the Section Neuro-oncology)

Neurocognitive and Neurophysiological Insights into Immersive Learning

edited by

Constantinos Halkiopoulos

and

Evgenia Gkintoni

submission deadline 31 Jan 2027 | Viewed by 80 | Submission Open

Keywords: immersive learning; neurocognitive; cognitive; neurophysiological; learning; attention; knowledge acquisition; artificial intelligence

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Depression, Anxiety and Related Psychiatric Disorders: Clinical Advances and Future Directions

edited by Danielle S. Cha

submission deadline 31 Jan 2027 | Viewed by 72 | Submission Open

Keywords: mental illness; depression; anxiety; disability; economic; treatment; artificial intelligence; prevention; stigma; function

(This special issue belongs to the Section Neuropsychiatry)

Sexual Behavior and the Brain: A Behavioral Neuroscience Perspective

edited by Anders Agmo and

Fay Guarraci

submission deadline 31 Jan 2027 | Viewed by 16 | Submission Open

Keywords: sexual motivation; preoptic area; ventral nucleus of the hypothalamus; sexual reward; copulatory behavior; amygdala; preference; male; female

(This special issue belongs to the Section Behavioral Neuroscience)

Clinical Research on Pain: Advances and Challenges

edited by Mariateresa Giglio

submission deadline 10 Feb 2027 | 1 articles | Viewed by 1711 | Submission Open

Keywords: pain management; chronic pain; pain research; analgesia; multidisciplinary approach

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Epilepsy Among Children and Adolescents

edited by Emanuele Bartolini

submission deadline 15 Feb 2027 | Viewed by 76 | Submission Open

Keywords: pediatric epilepsy; neurodevelopment; therapy; genetics; neuroimaging; precision medicine; comorbidities

(This special issue belongs to the Section Developmental Neuroscience)

Neuromarketing, Neuroeconomics, Neurotourism and Neuro-Robotics: Neural Mechanisms of Experience, Decision-Making and Interaction

edited by

Lucilia Cardoso

, Luiz Moutinho and Carla Fraga

submission deadline 15 Feb 2027 | Viewed by 55 | Submission Open

Keywords: biometrics; decision-making; embodied intelligence; experience; human– machine interaction; neuro-robotics; neuroeconomics; neuromarketing; neuroscience; neurotourism; smart tourism

Hot Topics in Multiple Sclerosis and Related Autoimmune Disorders

edited by Shitiz Sriwastava

submission deadline 15 Feb 2027 | Viewed by 32 | Submission Open

Keywords: Bruton’ s tyrosine kinase inhibitors (BTKi); multiple sclerosis; progressive multiple sclerosis; relapsing multiple sclerosis; microglia; B cells; neuroinflammation; fenebrutinib; tolebrutinib; evobrutinib

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Systemic Orchestration of Brain Networks: Neuroendocrine and Gut–Brain Insights into Functional Connectivity

edited by Valeria Paola Carlini

submission deadline 20 Feb 2027 | Viewed by 213 | Submission Open

Keywords: functional connectivity; neuroendocrinology; hormonal modulation; connectomics; brain network dynamics; neuroplasticity; psychoneuroendocrinology; steroid hormones; cognitive neuroscience; resting state fMRI

(This special issue belongs to the Section Systems Neuroscience)

Perioperative Neuroprotection: Mechanisms, Monitoring, and Clinical Strategies

edited by Shaun E. Gruenbaum

submission deadline 25 Feb 2027 | Viewed by 89 | Submission Open

Keywords: perioperative neuroprotection; surgery; brain health

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Post-Stroke Cognition, Sensorimotor Motor Control, and Strategies for Non-Invasive Neuromodulation

edited by

Oluwole Oladimeji Awosika

submission deadline 25 Feb 2027 | Viewed by 58 | Submission Open

Keywords: cognitive and sensory contributions to recovery; neuromodulation for cognitive and sensorimotor rehabilitation; metrics for cognition and sensorimotor function; biomarkers of training response; interventions involving post-stroke depression; psychological adjustment and patient– caregiver outcomes

(This special issue belongs to the Section Neurorehabilitation)

Cognitive Decline and Parkinson's Disease

edited by Mandy Roheger and Anja Ophey

submission deadline 28 Feb 2027 | Viewed by 96 | Submission Open

Keywords: Parkinson’ s disease; PDD; PD-MCI; cognitive reserve; cognitive decline; cognition; cognitive trajectories; prevention; digital biomarkers

(This special issue belongs to the Section Neurodegenerative Diseases)

Toward Reliable Non-Invasive Brain Stimulation: Unraveling Sources of Variability

edited by

Giacomo Guidali

submission deadline 28 Feb 2027 | Viewed by 76 | Submission Open

Keywords: non-invasive brain stimulation; transcranial electric stimulation (tES); transcranial magnetic stimulation (TMS); variability; reproducibility; neuroimaging; machine learning; precision neuromodulation; individual differences; protocol standardization

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

The Developing Dopamine System: Circuits, Behavior, and Disease

edited by Suzanne O. Nolan and Deborah J. Luessen

submission deadline 1 Mar 2027 | Viewed by 360 | Submission Open

Keywords: genetically encoded biosensors; fast scan cyclic voltammetry; fiber photometry; operant behavior; neuropsychiatric disease; developmental vulnerability; circuit maturation; early life adversity; mesolimbic dopamine; mesocortical dopamine

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

The Future of Psychological Treatments: Precision Approaches and Emerging Methods

edited by Alessandro Grecucci,

Irene Messina

and Davide Rivolta

submission deadline 28 Mar 2027 | Viewed by 284 | Submission Open

Keywords: psychotherapy; psychiatry; precision psychiatry; computational psychiatry; emotion regulation; process-based therapy; machine learning

(This special issue belongs to the Section Neuropsychiatry)

Modern Aspects of Neurorehabilitation

edited by

Hans-Jürgen Gdynia

submission deadline 31 Mar 2027 | Viewed by 56 | Submission Open

Keywords: neurorehabilitation; rehabilitation; neuroplasticity; neurorestoration; motor learning

(This special issue belongs to the Section Neurorehabilitation)

Neurorehabilitation Insight 2026: AI, Robots and Digital Technologies

edited by

Giovanni Morone

Rocco Salvatore Calabrò

and

Irene Ciancarelli

submission deadline 10 Apr 2027 | Viewed by 279 | Submission Open

Keywords: rehabilitation; use center design; personalized medicine; robot; exoskeleton; brain computer interfaces; sensors; robot-assisted training; virtual reality; neurotechnology

(This special issue belongs to the Section Neurorehabilitation)

Advancing Migraine Research: From Pathogenesis, Diagnosis to Treatments

edited by

Yasushi Shibata

submission deadline 30 Apr 2027 | Viewed by 228 | Submission Open

Keywords: migraine; pathophysiology; biomarker; imaging; CGRP; neuro-modulation

(This special issue belongs to the Section Sensory and Motor Neuroscience)

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