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Brain Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Approaches for Treatment-Resistant Depression

edited by Yuliya O. Knyahnytska

submission deadline 30 Nov 2025 | Viewed by 24 | Submission Open

Keywords: treatment resistant depression; hard-to-treat mood disorders; innovative interventions; therapeutic brain stimulation interventions; neuromodulation interventions; novel psychotropics

(This special issue belongs to the Section Neuropsychiatry)

Chronic Non-Infectious Diseases with a High Impact on the Central Nervous System

edited by

Grazyna Lietzau

submission deadline 5 Dec 2025 | 3 articles | Viewed by 1934 | Submission Open

Keywords: mental disorders; metabolic diseases; migraine; movement disorders; multiple sclerosis; neurodegenerative diseases; stroke

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Advances in Cognitive and Psychometric Evaluation

edited by

Rubén Trigueros Ramos

José M. Aguilar-Parra

and

Rocío Collado-Soler

submission deadline 10 Dec 2025 | Viewed by 80 | Submission Open

Keywords: cognitive assessment; psychometric evaluation; measurement innovation; advanced data analysis; affective assessment

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Pharmacy and Mental Health

edited by

Kyle Burghardt

submission deadline 10 Dec 2025 | Viewed by 10 | Submission Open

Keywords: pharmacy; mental health; pharmacists

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Interoception and Women’s Health

edited by

Jennifer Todd

and Jennifer Murphy

submission deadline 12 Dec 2025 | 1 articles | Viewed by 9680 | Submission Open

Keywords: interoception; women’ s health; sex differences; healthcare disparities; reproductive health

(This special issue belongs to the Section Neuropsychology)

The Use of Robotics and Artificial Intelligence in Neurorehabilitation: From Diagnosis to Treatment

edited by

Rocco Salvatore Calabrò

David Perpetuini

and

Irene Aprile

submission deadline 15 Dec 2025 | 4 articles | Viewed by 11230 | Submission Open

Keywords: robotic-assisted rehabilitation; machine learning; neurological disorders; artificial intelligence

(This special issue belongs to the Section Neurorehabilitation)

Neuromodulation for Pain Management: Evidence of Safety and Efficacy

edited by

Andrés Molero-Chamizo

and Rafael Tomás Andújar-Barroso

submission deadline 15 Dec 2025 | Viewed by 613 | Submission Open

Keywords: chronic pain; clinical neurostimulation; invasive neuromodulation; neurostimulation-induced plasticity; non-invasive neuromodulation; pain management; transcranial electric stimulation; transcranial magnetic stimulation

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Perinatal Psychiatry: Mental Health During Pregnancy and the Postpartum

edited by Saulo Gantes Tractenberg,

Thiago Wendt Viola

and Tagma Marina Schneider Donelli

submission deadline 15 Dec 2025 | Viewed by 116 | Submission Open

Keywords: perinatal; postpartum; mental health; pregnancy; postpartum depression; postpartum psychosis; psychiatric disorders; puerperal disorders; infant; perinatal care

(This special issue belongs to the Section Neuropsychiatry)

Machine Learning and Artificial Intelligence Algorithms in Neuroscience

edited by Mohsen Ahmadi

submission deadline 15 Dec 2025 | Viewed by 72 | Submission Open

Keywords: machine learning; artificial intelligence; computational neuroscience; deep learning; neuroimaging; brain– computer interfaces; neural signal processing; cognitive modeling; neurodegenerative diseases; explainable AI

(This special issue belongs to the Section Computational Neuroscience and Neuroinformatics)

Advanced Optical Neuroimaging and Neurotransmitter Analysis in Cortical Circuits and Sensory Processing

edited by

Kurtulus Golcuk

submission deadline 15 Dec 2025 | Viewed by 57 | Submission Open

Keywords: Optical neuroimaging; Neurotransmitter dynamics; Cortical circuits; Sensory processing; Fiber Photometry; Two-Photon microscopy; Neuromodulation; Neurological disorders; Neurophysiological diseases

(This special issue belongs to the Section Systems Neuroscience)

The Microbiome in Neurological Disorders

edited by

Keehoon Lee

submission deadline 20 Dec 2025 | Viewed by 44 | Submission Open

Keywords: microbiome; brain– microbiome axis; brain– gut axis; neurological disorders; neurodegenerative; neurodevelopmental; neuroinflammatory; human microbiome

Falls: Developing, Understanding, and Communicating Effective Interventions

edited by

Shashank Ghai

submission deadline 20 Dec 2025 | Viewed by 27 | Submission Open

Keywords: gait; posture; fall prevention; balance disorders; rehabilitation; assistive technology; neurological disorders; wearable devices; intervention strategies; clinical practice; intervention communication

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Non-Antibody Based Anti-Aggregation Therapies Targeting Amyloid-Beta, Tau and Alpha-Synuclein and Other Proteins Associated With Neurodegenerative Disorders

edited by

Bruno Meloni

submission deadline 20 Dec 2025 | Viewed by 12 | Submission Open

Keywords: amyloid-beta (Aβ ) aggregation; Tau aggregation; alpha-synuclein (α -Syn) aggregation; TAR DNA-binding protein 43 (TDP-43) aggregation; superoxide dismutase (SOD1) aggregation; Huntingtin (HTT) aggregation; prion protein (PrPᶜ); protein aggregation; anti-protein aggregating agents; proteinopathies; neurodegeneration

(This special issue belongs to the Section Neurodegenerative Diseases)

Primary Progressive Aphasia: What Happens to Speech and Language? What Can We Do to Help?

edited by

Monica Lavoie

, Anna P. Volkmer, Jason D. Warren and

Petronilla Battista

submission deadline 21 Dec 2025 | Viewed by 31 | Submission Open

Keywords: primary progressive aphasia; language; brain; communication; cognition

(This special issue belongs to the Section Neurolinguistics)

Advances in Speech and Language Research in Aging Populations: Insights for Cognitive Well-Being

edited by

Maria Teresa Carthery-Goulart

submission deadline 21 Dec 2025 | Submission Open

Keywords: communication skills; language abilities; speech; cognitive function; neurodegenerative diseases; neuromodulation

(This special issue belongs to the Section Neurolinguistics)

Artificial Intelligence in Neurological Disorders

edited by

Rahul Kashyap

and

Pallavi Dinesh Shirsat

submission deadline 24 Dec 2025 | Viewed by 255 | Submission Open

Keywords: artificial intelligence; neurological disorders; machine learning; deep learning; neuroimaging; Alzheimer’ s disease; Parkinson’ s disease; predictive analytics; personalized medicine; ethical AI

(This special issue belongs to the Section Computational Neuroscience and Neuroinformatics)

Using Neuroimaging to Explore Neurodegenerative Diseases

edited by

Ting Shen

submission deadline 25 Dec 2025 | Viewed by 135 | Submission Open

Keywords: neuroimaging; neurodegenerative diseases; multidisciplinary research; imaging-omics study; multimodal integration; AI-driven analytics

(This special issue belongs to the Section Neurodegenerative Diseases)

Risk Factors for Tinnitus and Tinnitus-Related Disease

edited by

Alessandra Fioretti

, Roland Moschen and Alberto Eibenstein

submission deadline 25 Dec 2025 | Viewed by 15 | Submission Open

Keywords: tinnitus; anxiety; depression; stress; migraine; hearing loss; insomnia; biomarkers; noise; ototoxicity

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Brain Stimulation for Psychiatric Disorders: Emerging Evidence and New Perspectives—2nd Edition

edited by

Jacopo Lisoni

and

Stefano Barlati

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2106 | Submission Open

Keywords: repetitive transcranial magnetic stimulation (rTMS) and Theta burst stimulation (TBS); transcranial electrical stimulation (tES) (transcranial direct current stimulation (tDCS); transcranial alternating current stimulation (tACS); transcranial random noise stimulation (tRNS)); magnetic seizure therapy (MST); depression; bipolar disorder; and other mood disorders; schizophrenia and psychosis; obsessive– compulsive disorder and anxiety disorders; substance use disorders; neurodevelopmental disorders (ADHD; autism); neuroimaging; neurophysiology; cognition

(This special issue belongs to the Section Neuropsychiatry)

Cellular and Molecular Mechanisms Regulating Neuronal Function, Homeostasis, and Disease

edited by

Daniel José Barbosa

and

Ana Filipa Sobral

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1736 | Submission Open

Keywords: molecular mechanisms; cellular mechanisms; neuronal function; neuronal homeostasis; neuronal health; neuronal development; neuronal metabolism; neuron– glia interactions; synaptic plasticity; biomarkers of early diagnosis; neurodegeneration; brain diseases

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Neural Mechanisms Underlying Sensorimotor Learning and Plasticity: Novel Advances and Future Perspectives

edited by

Giacomo Guidali

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1488 | Submission Open

Keywords: sensorimotor learning; brain plasticity; cognitive neuroscience; neurophysiology; non-invasive brain stimulation; EEG; neuromodulation; motor system; visual system; somatosensory system

(This special issue belongs to the Section Systems Neuroscience)

Quantifying Motor Neurone Disease: Advances and Challenges in Developing Biomarkers, Predictive Models and Outcome Measures

edited by Roisin McMackin and

Joke De Vocht

submission deadline 31 Dec 2025 | Viewed by 135 | Submission Open

Keywords: amyotrophic lateral sclerosis; primary lateral sclerosis; progressive muscular atrophy; biomarkers (cognition; neurophysiology; biofluid markers; neuroimaging); modelling; therapeutic development; early detection and diagnosis; precision medicine

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Recent Advances in Assessment and Rehabilitation of Communication and Language Disorders: Enhancing Innovations, Neuromodulation and AI

edited by

Dionysus Tafiadis

, Nafsika Ziavra,

Angelos Papadopoulos

and

Konstantinos Drosos

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: lifespan speech and language disorders; lifespan communication disorders; special learning disabilities; lifespan voice and swallowing disorders; assessment; intervention; innovations; neuromodulation; artificial intelligence

(This special issue belongs to the Section Neurolinguistics)

Neuroscience of Learning, Mental Health, and Cultural Adaptation: Cognitive, Pedagogical, and Psychological Perspectives

edited by

Evgenia Gkintoni

Georgios Nikolaou

and

Stephanos Ph Vassilopoulos

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: cognitive neuroscience; mental health and learning; cultural adaptation; educational neuroscience; neuropsychology of learning; pedagogical interventions; emotional resilience in education; multicultural and inclusive education; neural mechanisms of learning; cross-cultural pedagogy

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Advances in Psychopharmacology in Neurodevelopmental Disorders (NDDs)

edited by Shoumitro Deb

submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open

Keywords: neurodevelopmental disorders; psychopharmacology; research; recent advances; mental health medicine

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

The Future of Human–Machine Collaboration: AI in Neural Rehabilitation and Assistive Technologies

edited by

Cristian Randieri

submission deadline 31 Dec 2025 | 1 articles | Viewed by 79 | Submission Open

Keywords: artificial intelligence; neural rehabilitation; brain– computer interface; neuroprosthetics; machine learning; rehabilitation robotics; neuroengineering; assistive technology; wearable devices; neurosignal processing

(This special issue belongs to the Section Neural Engineering, Neuroergonomics and Neurorobotics)

New Advances in Functional Neurosurgery—2nd Edition

edited by

Nicola Montano

submission deadline 31 Dec 2025 | Viewed by 61 | Submission Open

Keywords: functional neurosurgery; trigeminal neuralgia; microvascular decompression; deep brain stimulation; neuromodulation; spinal cord stimulation; epilepsy surgery; neurophysiological intraoperative monitoring; artificial intelligence in neurosurgery; MR-guided focused ultrasound (MRgFUS); laser interstitial thermal therapy (LiTT)

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

At the Frontiers of Neurorehabilitation: 3rd Edition

edited by

Manuel Gaviria

submission deadline 31 Dec 2025 | Viewed by 59 | Submission Open

Keywords: CNS trauma; ischemic CNS injury; neurodegenerative disorders; neurorehabilitation; neuroplasticity; personalized therapy; optimization of clinical care; motor learning; cognitive reinforcement; motivational issues; relevant outcome measures; innovative approaches; rehabilitation devices; neuro-prosthetics; brain– computer interfaces; clinical trials for validation; regulatory issues; activities of daily living (ADLs) autonomy; quality of life; neurodevelopmental disorder

(This special issue belongs to the Section Neurorehabilitation)

Neural Mechanisms Underlying Social Cognition and Emotional Processing

edited by

Atiqah Azhari

submission deadline 10 Jan 2026 | Viewed by 37 | Submission Open

Keywords: social cognition; emotional processing; social neuroscience; developmental neuroscience

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Deep Research into Stroke

edited by

Min Su Kim

submission deadline 15 Jan 2026 | Viewed by 30 | Submission Open

Keywords: stroke; rehabilitation; neuromodulation; physical therapy; robotics; artificial intelligence; neuroimaging; deep learning; machine learning; exercise

(This special issue belongs to the Section Neurorehabilitation)

Beyond Boundaries: Current Advances in Developmental Learning Disorders

edited by Daniela Traficante and

Luisa Girelli

submission deadline 15 Jan 2026 | Viewed by 24 | Submission Open

Keywords: developmental learning disorders; transdiagnostic approach; comorbidity; domain-general components

(This special issue belongs to the Section Neuropsychology)

Perception Across Disciplines: Exploring the Intersections of Cognitive, Social, Affective and Neural Dimensions

edited by

Yang Zhang

submission deadline 18 Jan 2026 | Viewed by 22 | Submission Open

Keywords: sensory processing; cognitive systems; perception-action binding; multimodal processing; neural foundations; socio-affective systems; computational models; interdisciplinary research

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Assessment and Rehabilitation of Cognitive Function in Neurological Disorders

edited by Gilles Naeije

submission deadline 25 Jan 2026 | Viewed by 13 | Submission Open

Keywords: post-stroke cognitive impairment; diaschisis; cerebellum; cortico-cerebellar connectivity; neuromodulation; transcranial cerebellar stimulation; cognitive rehabilitation; functional connectivity

(This special issue belongs to the Section Neurorehabilitation)

Advances in the Relationship Among Brain, Physical Function, and Exercise Performance

edited by

Luca Petrigna

submission deadline 30 Jan 2026 | Viewed by 70 | Submission Open

Keywords: physical performance; dual task; cognition; sport; environment; cerebellum; movement; neurodegenerative disease

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Advances in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease

edited by

Pavan Kumar

submission deadline 31 Jan 2026 | 4 articles | Viewed by 6744 | Submission Open

Keywords: neurodegeneration; neuroprotection; neurogenesis; learning and memory; engram; neuro-vascular

(This special issue belongs to the Section Neurodegenerative Diseases)

The Eye as the Window to Brain Science: Fields of Neuroscience Created from Eye Research

edited by

George Ayoub

submission deadline 31 Jan 2026 | Viewed by 18 | Submission Open

Keywords: sensory system functions; neuroanatomy; neurochemistry; neurophysiology; developmental neurobiology; neurological health and disease

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Advances in the Diagnosis, Visualization and Treatment of Intracranial Aneurysms and Subarachnoid Hemorrhage

edited by

Serge Marbacher

and Lukas Andereggen

submission deadline 31 Jan 2026 | Viewed by 16 | Submission Open

Keywords: neurovascular; intracranial aneurysm; subarachnoid hemorrhage; education and teaching; imaging technology; hybrid operating room; augmented reality; cerebrovascular disease; cost-effectiveness; artificial intelligence

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Neuropathic Pain: From Physiopathology to Improvements in Diagnosis and Management

edited by Caren Tatiane De David Antoniazzi and Patricia Rodrigues

submission deadline 15 Feb 2026 | Viewed by 33 | Submission Open

Keywords: neuropathic pain; pain mechanisms; neuroinflammation; sensitization; biomarkers; chronic pain; somatosensory system; pain diagnosis; personalized medicine; pain management

(This special issue belongs to the Section Sensory and Motor Neuroscience)

The Role of Glia in Inflammatory Processes

edited by

Charles Elias Assmann

and Margarete Dulce Bagatini

submission deadline 16 Feb 2026 | 3 articles | Viewed by 2736 | Submission Open

Keywords: neuroinflammation; neurodegenerative and psychiatric disorders; microglia; astrocytes; purinergic signaling; bioactive and natural compounds; immunopharmacology and immunotoxicology; oxidative and nitrosative stress; neuroimaging; neuroscience and behavior

(This special issue belongs to the Section Neuroglia)

Advances in Assessment and Training of Perceptual-Motor Performance (2nd Edition)

edited by Gary Wilkerson and

Scott L. Bruce

submission deadline 28 Feb 2026 | Viewed by 70 | Submission Open

Keywords: perception; cognition; motor control; neural efficiency; traumatic brain injury; neurodegeneration; psycho-affective disorder

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Cellular and Molecular Mechanisms Underlying Aging Progression

edited by

Mateus Vidigal de Castro

submission deadline 28 Feb 2026 | Viewed by 10 | Submission Open

Keywords: neuroaging ; neurodegeneration ; iPSC-derived models ; omics technologies ; cellular senescence ; neuroinflammation ; longevity

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Risks and Mechanisms in Addiction Neuroscience Informing Treatment

edited by Amy A. Herrold

submission deadline 7 Mar 2026 | Viewed by 30 | Submission Open

Keywords: substance use disorders; risk; mechanism; neuromodulation; psychedelic; GLP-1

(This special issue belongs to the Section Neuropsychiatry)

Palliative Care for Patients with Severe Neurological Impairment

edited by

Giovanna Artioli

and

Federica Dellafiore

submission deadline 30 Mar 2026 | Viewed by 302 | Submission Open

Keywords: severe neurological impairment; neurological chronic disease; palliative care; early palliative care; nursing competencies; advance care planning; caregiver support; mental Illness of Healthcare professionals; non pharmacological and complementary treatment; bio-psyco-social and existential needs of patient and caregiver

(This special issue belongs to the Section Neurorehabilitation)

Plasticity of Sensory Cortices: From Basic to Clinical Research

edited by Stephanie Clarke and Sonia Crottaz-Herbette

submission deadline 31 Mar 2026 | Viewed by 40 | Submission Open

Keywords: tonotopy; retinotopy; somatotopy; vestibular; olfactory; gustatory; training-induced plasticity; postlesional plasticity; cochlear implant; prostheses

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Advances in Immune-Mediated Disorders of the Nervous System in Childhood

edited by Martino Ruggieri and

Andrea Domenico Praticò

submission deadline 10 Apr 2026 | Viewed by 12 | Submission Open

Keywords: autoimmune encephalitis; pediatric neuroinflammation; immune-mediated CNS disorders; childhood multiple sclerosis; MOG antibody disease; neuroimmunology; immunotherapy in children; neuromyelitis optica

(This special issue belongs to the Section Developmental Neuroscience)

Review in Neuropsychology: Advances and Future Directions

edited by

Sara Palermo