Surgical and Non-Surgical Convergence in Hepatocellular Carcinoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 23
Special Issue Editor
Interests: hepatocellular carcinoma; multiparametric therapeutic hierarchy; conversion therapy; liver transplantation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) remains a significant global health burden, with 866,136 new cases and a mortality-to-incidence ratio of 0.86 reported in 2022. Primarily caused by liver cirrhosis, HCC is increasingly linked to non-viral causes, particularly metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease. While liver transplantation and resection continue to be the main curative options, the past decade has seen notable advances in non-surgical treatments—including ablation, transarterial therapies, and systemic treatments—that have transformed the therapeutic landscape.
Instead of being seen as alternative or competing options, these treatments are increasingly regarded within integrative frameworks, such as the Multiparametric and Converse Therapeutic Hierarchies, where combined and sequential strategies reveal curative possibilities that were once considered unreachable.
This special issue invites original research, high-quality reviews, and translational perspectives that challenge traditional staging and treatment paradigms while exploring the integration of surgical and non-surgical approaches in HCC. Special focus will be on studies addressing downstaging, curative conversion, therapeutic stage migration, and multiparametric/multidisciplinary decision-making approaches.
By bringing together work at the forefront of integrated HCC management, this issue strives to define a future where therapeutic boundaries are flexible, personalised for patients, and focused on maximising survival and potential for cure.
Dr. Alessandro Vitale
Guest Editor
Marco Brolese
Ilaria Govoni
Virginia Padoan
Guest Editor Assistants
Manuscript Submission Information
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Keywords
- hepatocellular carcinoma
- conversion therapy
- HCC treatment boundaries
- surgical–non-surgical convergence
- multidisciplinary HCC management
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